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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

PtdIns-(1-arachidonoyl, 2-arachidonoyl-d8) (ammonium salt) Exclusive

Cayman Chemical Item Number 9000305

PtdIns-(1-arachidonoyl, 2-arachidonoyl-d8) (ammonium salt)

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Description

PtdIns-(1-arachidonoyl, 2-arachidonoyl-d8) is used as an internal standard for the quantification of PtdIns-(1-arachidonoyl, 2-arachidonoyl) by stable isotope dilution MS. The accuracy of the sample weight in this vial is between 5% over and 2% under the amount shown on the vial. If better precision is required, the deuterated standard should be quantitated against a more precisely weighed unlabeled standard by constructing a standard curve of peak intensity ratios (deuterated versus unlabeled). The phosphatidylinositols (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(1-arachidonoyl, 2-arachidonoyl-d8) (sodium salt) is a synthetic analog of natural PtdIns featuring deuterated C20:4 fatty acids at the sn-2 position. This synthetic standard compound contains the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound.

1 Lapetina, E.G., Billah, M.M., and Cuatrecasas, P. The phosphatidylinositol cycle and the regulation of arachidonic acid production. Nature 292 367-369 (1981).

2 Pike, L.J., and Casey, L. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains. J Biol Chem 271 26453-26456 (1996).

Formal Name 1-​(1-​(5Z,​8Z,​11Z,​14Z)-​eicosatetraenoyl-​2R-​(5Z,​8Z,​11Z,​14Z)-​eicosatetraenoyl-​5,​6,​8,​9,​11,​12,​14,​15-​d8-​phosphatidyl)inositol,​ monoammonium salt
Molecular Formula C49H70D8O13P · NH4
Formula Weight 932.2
Formulation A lyophilized powder
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@@H]​(O)​[C@@H]​(O)​[C@@H]​(OP([O-]​)​(OC[C@H]​(OC(CCC/C([2H]​)​=C([2H]​)​\C/C([2H]​)​=C([2H]​)​\C/C([2H]​)​=C([2H]​)​\C/C([2H]​)​=C([2H]​)​\CCCCC)​=O)​COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)​=O)​=O)​[C@H]​(O)​[C@H]​1O.[NH4+]​

Background Reading

Lapetina, E.G., Billah, M.M., and Cuatrecasas, P. The phosphatidylinositol cycle and the regulation of arachidonic acid production. Nature 292 367-369 (1981).

Pike, L.J., and Casey, L. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains. J Biol Chem 271 26453-26456 (1996).
Size Price Quantity Subtotal
25 µg $97.00 $0.00
50 µg $184.00 $0.00
100 µg $349.00 $0.00
500 µg $1,552.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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