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Methylcarbamyl PAF C-8 Exclusive

Cayman Chemical Item Number 9000332

Methylcarbamyl PAF C-8

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Description

Methylcarbamyl PAF C-8 is the C-8 analog of Methylcarbamyl PAF C-16. Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.1,2 It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.1 In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc, c-fos, and the activation of mitogen-activated protein kinase.2 Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.2

1 Hadváry, P., Cassal, J., Hirth, G., et al. Structural requirements for the activation of blood platelets by analogues of platelet-activating factor (PAF-acether). Platelet-Activating Factor INSERM Symposium 23 57-64 (1983).

2 Kume, K., and Shimizu, T. Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. J Biol Chem 272 22898-22904 (1997).

Formal Name 1-​O-​octyl-​2-​O-​(N-​methylcarbamoyl)-​sn-​glyceryl-​3-​phosphorylcholine
Molecular Formula C18H39N2O7P
Formula Weight 426.5
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCOC[C@@H]​(OC(N([H]​)​C)​=O)​COP(OCC[N+]​(C)​(C)​C)​([O-]​)​=O

Background Reading

Kume, K., and Shimizu, T. Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. J Biol Chem 272 22898-22904 (1997).

Hadváry, P., Cassal, J., Hirth, G., et al. Structural requirements for the activation of blood platelets by analogues of platelet-activating factor (PAF-acether). Platelet-Activating Factor INSERM Symposium 23 57-64 (1983).
Size Global Purchasing
1 mg See a distributor in your region for pricing
5 mg See a distributor in your region for pricing
10 mg See a distributor in your region for pricing
25 mg See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

Related Products

Lyso-PAF C-16
Methylcarbamyl PAF C-16
PAF C-16
PAF C-16-d4
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