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17-keto-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid Exclusive

Cayman Chemical Item Number 9000347

17-keto-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

See more	Fatty Acids (272)

Description

Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-keto-(7Z,10Z,13Z,15E,19Z) docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity.^1,2 It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC₅₀ ~200nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM).²

1 Jie, M.S.F.L.K., and Pasha, M.K. Fatty acids, fatty acid analogues and their derivatives. Nat Prod Rep 607-629 (1998).

2 Groeger, A.L., Cipollina, C., Cole, M.P., et al. Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. Nat Chem Biol (2010).

Formal Name	7Z,10Z,13Z,15E,19Z-17-keto-docosapentaenoic acid
Molecular Formula	C₂₂H₃₂O₃
Formula Weight	344.5
Formulation	A solution in ethanol
Purity	≥95%
Stability	6 months
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC/C=C\CC(=O)/C=C\C=C\C/C=C\C/C=C\CCCCCC(=O)O

Background Reading

Groeger, A.L., Cipollina, C., Cole, M.P., et al. Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. Nat Chem Biol (2010).

Jie, M.S.F.L.K., and Pasha, M.K. Fatty acids, fatty acid analogues and their derivatives. Nat Prod Rep 607-629 (1998).

Size	Global Purchasing
100 µg	See a distributor in your region for pricing
250 µg	See a distributor in your region for pricing
500 µg	See a distributor in your region for pricing
1 mg	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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