2,3-dinor-6-keto Prostaglandin F1α-d9 (sodium salt)

2,3-dinor-6-keto Prostaglandin F_1α-d₉ (sodium salt)

Cayman Chemical Item Number 9000462

2,3-dinor-6-keto PGF_1α-d₉ (sodium salt)

Description

An internal standard for the quantification of 2,3-dinor-6-keto Prostaglandin F_1α by GC- or LC-MS. 2,3-dinor-6-keto prostaglandin F_1α (2,3-dinor-6-keto PGF_1α) is the β-oxidation product of 6-keto PGF_1α and the major urinary metabolite of PGI₂ in humans.^1,2 2,3-dinor-6-keto PGF_1α makes up 23% of the recovered radioactivity in urine after administration of labeled 6-keto PGF_1α and 20.5% after administration of labeled PGI₂.² In healthy human subjects, the average excreted 2,3-dinor-6-keto PGF_1α level is ~100 pg/mg creatinine.³

1 Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv Prostaglandin Thromboxane Leukot Res 15 87-90 (1985).

2 Rosenkranz, B., Fischer, C., Reimann, I., et al. Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F_1α in man. Biochim Biophys Acta 619 207-213 (1980).

3 Wennmalm Å, Benthin, G., Granström, E.F., et al. 2,3-Dinor metabolites of thromboxane A₂ and prostacyclin in urine from healthy human subjects: Diurnal variation and relation to 24h excretion. Clin Sci 83 461-465 (1992).

Synonyms

2,3-dinor-6-keto PGF1α-d9 (sodium salt)

Formal Name

6-oxo-9α,11α,15S-trihydroxy-2,3-dinor-prost-13E-en-1-oic 15,15,16,16,17,17,18,18,18-d9 acid, sodium salt

Molecular Formula

C₁₈H₂₀D₉O₆ · Na

Formula Weight

373.5

Formulation

A solution in methanol

Purity

≥99% deuterated product

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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O[C@@H]1[C@H](CC(CCC([O-])=O)=O)[C@@H](/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@H](O)C1.[Na+]

Background Reading

Rosenkranz, B., Fischer, C., Reimann, I., et al. Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F_1α in man. Biochim Biophys Acta 619 207-213 (1980).

Wennmalm Å, Benthin, G., Granström, E.F., et al. 2,3-Dinor metabolites of thromboxane A₂ and prostacyclin in urine from healthy human subjects: Diurnal variation and relation to 24h excretion. Clin Sci 83 461-465 (1992).

Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv Prostaglandin Thromboxane Leukot Res 15 87-90 (1985).

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25 µg 
$97.00

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50 µg 
$184.00

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100 µg 
$349.00

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500 µg 
$1,552.00

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2,3-dinor-6-keto Prostaglandin F_1α-d₉ (sodium salt)