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Palmitoyl Ethanolamide-d₄ Exclusive

Cayman Chemical Item Number 9000551

Palmidrol-d₄; PEA-hydroxyethyl-1,1,2,2-d₄

Palmitoyl Ethanolamide-d4

See more	Mass Spectrometry (265) Endocannabinoids (57) Fatty Acids (272) Neuroscience (725)

Description

Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.¹ PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.² PEA is an endocannabinoid which has been shown to significantly elevate cAMP in cells expressing CB₂ receptors. However, its affinity for CB₂ receptors is relatively low, at about 10 µM. CB₁ receptors have no appreciable affinity for PEA.³

1 Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

2 Ganley, O.H., Graessle, O.E., Robinson, H.J., et al. Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin. J Lab Clin Med 51 709-714 (1958).

3 Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

Synonyms	Palmidrol-d4 PEA-hydroxyethyl-1,1,2,2-d4
Formal Name	N-(2-hydroxyethyl-1,1,2,2-d4)-hexadecanamide
Molecular Formula	C₁₈H₃₃D₄NO₂
Formula Weight	303.5
Formulation	A solution in ethanol
Purity	≥99% deuterated forms (d1-d4)
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC([2H])([2H])C([2H])([2H])N([H])C(CCCCCCCCCCCCCCC)=O

Background Reading

Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

Size	Global Purchasing
100 µg	See a distributor in your region for pricing
500 µg	See a distributor in your region for pricing
1 mg	See a distributor in your region for pricing
5 mg	See a distributor in your region for pricing

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Batch-specific Information

FAQs

It appears that there is a heterogenous mixture of deuterated species in your deuterated standards; is this normal?

Yes, this is typical of our deuterated products. Our deuterated products contain less than 1 % d0. However, the labeled compounds are not 100% of the deuterated form listed on our product insert. For example, upon analysis of 2-arachidonoyl glycerol-d8 it is expected to see masses associated with the d7, d6, d5 etc.

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Palmitoyl Ethanolamide-d4 Exclusive