Cayman Chemical | Dimebolin | Description • Dimebon™ (CAS 3613-73-8)

9000556 Dimebolin

Dimebon™ (CAS 3613-73-8)

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Dimebolin is an orally-available drug, approved in Russia for use as a non-selective antihistamine, that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s ^1,2 and Huntington’s disease.³ In addition to reported activity in preventing the onset and progression of disease by being neuroprotective, dimebolin appears to promote clinical improvement by increasing cognitive function.^4,2 At the cellular level, dimebolin appears to have diverse effects, inhibiting the neurotoxic action of β-amyloid and blocking L-type calcium channels,⁵ inhibiting NMDA-type glutamate receptors,⁶ and preventing mitochondrial leakage.⁷

1 Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al. Dimebon improves learning in animals with experimental Alzheimer’s disease. Bulletin of Experimental Biology and Medicine 129(6) 640-642 (2000).

2 Doody, R.S., Gavrilova, S.I., Sano, M., et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: A randomised, double-blind, placebo-controlled study. Lancet 372 207-215 (2008).

3 Wu, J., Li, Q., Bezprozvanny, I. Evaluation of dimebon in cellular model of Huntington’s disease. Molecular Neurodegeneration (2008).

4 Bachurin, S., Bukatina, E., Lermontova, N., et al. Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. Ann N Y Acad Sci 939 425-435 (2001).

5 Lermontova, N.N., Redkozubov, A.E., Shevtsova, E.F., et al. Dimebon and tacrine inhibit neurotoxic action of β-amyloid in culture and block L-type Ca2+ channels. Bulletin of Experimental Biology and Medicine 132(5) 1079-1083 (2001).

6 Grigor'ev, V.V., Dranyi, O.A., Bachurin, S.O. Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bulletin of Experimental Biology and Medicine 136(5) 474-477 (2003).

7 Bachurin, S.O., Shevtsova, E.P., Kireeva, E.G., et al. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann N Y Acad Sci 993 334-344 (2003).

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Pricing updated 2010-03-16.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.