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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Dimebolin Exclusive

Cayman Chemical Item Number 9000556

Dimebon™ (CAS 3613-73-8)

Dimebolin (CAS 3613-73-8)

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Description

Dimebolin is an orally-available drug, approved in Russia for use as a non-selective antihistamine, that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s 1,2 and Huntington’s disease.3 In addition to reported activity in preventing the onset and progression of disease by being neuroprotective, dimebolin appears to promote clinical improvement by increasing cognitive function.4,2 At the cellular level, dimebolin appears to have diverse effects, inhibiting the neurotoxic action of β-amyloid and blocking L-type calcium channels,5 inhibiting NMDA-type glutamate receptors,6 and preventing mitochondrial leakage.7

1 Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al. Dimebon improves learning in animals with experimental Alzheimer’s disease. Bull Exp Biol Med 129(6) 640-642 (2000).

2 Doody, R.S., Gavrilova, S.I., Sano, M., et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: A randomised, double-blind, placebo-controlled study. Lancet 372 207-215 (2008).

3 Wu, J., Li, Q., and Bezprozvanny, I. Evaluation of dimebon in cellular model of Huntington’s disease. Mol Neurodegener 3(15) (2008).

4 Bachurin, S., Bukatina, E., Lermontova, N., et al. Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. Ann N Y Acad Sci 939 425-435 (2001).

5 Lermontova, N.N., Redkozubov, A.E., Shevtsova, E.F., et al. Dimebon and tacrine inhibit neurotoxic action of β-amyloid in culture and block L-type Ca2+ channels. Bull Exp Biol Med 132(5) 1079-1083 (2001).

6 Grigor'ev, V.V., Dranyi, O.A., and Bachurin, S.O. Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 136(5) 474-477 (2003).

7 Bachurin, S.O., Shevtsova, E.P., Kireeva, E.G., et al. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann N Y Acad Sci 993 334-344 (2003).

Synonyms
  • Dimebon™
Formal Name 2,​3,​4,​5-​tetrahydro-​2,​8-​dimethyl-​5-​[2-​(6-​methyl-​3-​pyridinyl)ethyl]-​1H-​pyrido[4,​3-​b]indole
CAS Number 3613-73-8
Molecular Formula C21H25N3
Formula Weight 319.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC1=CC=C(N(CCC2=CC=C(C)​N=C2)​C3=C4CN(C)​CC3)​C4=C1

Background Reading

Wu, J., Li, Q., and Bezprozvanny, I. Evaluation of dimebon in cellular model of Huntington’s disease. Mol Neurodegener 3(15) (2008).

Bachurin, S., Bukatina, E., Lermontova, N., et al. Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. Ann N Y Acad Sci 939 425-435 (2001).

Grigor'ev, V.V., Dranyi, O.A., and Bachurin, S.O. Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 136(5) 474-477 (2003).

Doody, R.S., Gavrilova, S.I., Sano, M., et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: A randomised, double-blind, placebo-controlled study. Lancet 372 207-215 (2008).

Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al. Dimebon improves learning in animals with experimental Alzheimer’s disease. Bull Exp Biol Med 129(6) 640-642 (2000).

Bachurin, S.O., Shevtsova, E.P., Kireeva, E.G., et al. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann N Y Acad Sci 993 334-344 (2003).

Lermontova, N.N., Redkozubov, A.E., Shevtsova, E.F., et al. Dimebon and tacrine inhibit neurotoxic action of β-amyloid in culture and block L-type Ca2+ channels. Bull Exp Biol Med 132(5) 1079-1083 (2001).

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Size Price Quantity Subtotal
1 mg $16.00 $0.00
5 mg $72.00 $0.00
10 mg $128.00 $0.00
25 mg $280.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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