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Palmitoyl Ethanolamide-d5 Exclusive

Cayman Chemical Item Number 9000573

PEA-15,15,16,16,16-d5; Palmidrol-d5

Palmitoyl Ethanolamide-d5

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Description

Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.1 PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.2 PEA is an endocannabinoid which has been shown to significantly elevate cAMP in cells expressing CB2 receptors. However, its affinity for CB2 receptors is relatively low, at about 10 µM. CB1 receptors have no appreciable affinity for PEA.3

1 Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

2 Ganley, O.H., Graessle, O.E., Robinson, H.J., et al. Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin. J Lab Clin Med 51 709-714 (1958).

3 Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

Synonyms
  • PEA-15,15,16,16,16-d5
  • Palmidrol-d5
Formal Name N-​(2-​hydroxyethyl)-​hexadecanamide-​15,​15,​16,​16,​16-​d5
Molecular Formula C18H32D5NO2
Formula Weight 304.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d5)
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C(NCCO)​CCCCCCCCCCCCCC([2H]​)​([2H]​)​C([2H]​)​([2H]​)​[2H]​

Background Reading

Ganley, O.H., Graessle, O.E., Robinson, H.J., et al. Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin. J Lab Clin Med 51 709-714 (1958).

Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

Size Global Purchasing
100 µg See a distributor in your region for pricing
500 µg See a distributor in your region for pricing
1 mg See a distributor in your region for pricing
5 mg See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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Batch-specific Information

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FAQs

It appears that there is a heterogenous mixture of deuterated species in your deuterated standards; is this normal?

Yes, this is typical of our deuterated products. Our deuterated products contain less than 1 % d0. However, the labeled compounds are not 100% of the deuterated form listed on our product insert. For example, upon analysis of 2-arachidonoyl glycerol-d8 it is expected to see masses associated with the d7, d6, d5 etc.

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