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Docosahexaenoyl Serotonin Exclusive

Cayman Chemical Item Number 9000639

(CAS 283601-58-1)

Docosahexaenoyl Serotonin (CAS 283601-58-1)

See more	Inhibitors (546) Pain (151) Signal Transduction (328)

Description

Docosahexaenoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Catalog No. 70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid 1 (TRPV1) channel, reducing both acute and chronic peripheral pain.^1,2 The effects of replacing the arachidonoyl portion with docosahexaenoyl have not been studied.

1 Ortar, G., Cascio, M.G., De Petrocellis, L., et al. New N-arachidonoylserotonin analogues with potential “dual” mechanism of action against pain. J Med Chem 50 6554-6569 (2007).

2 Maione, S., De Petrocellis, L., de Novellis, V., et al. Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br J Pharmacol 150 766-781 (2007).

Formal Name	N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenamide
CAS Number	283601-58-1
Molecular Formula	C₃₂H₄₂N₂O₂
Formula Weight	486.7
Formulation	A solution in ethanol
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCC1=CNC2=CC=C(O)C=C12)=O

Background Reading

Maione, S., De Petrocellis, L., de Novellis, V., et al. Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br J Pharmacol 150 766-781 (2007).

Ortar, G., Cascio, M.G., De Petrocellis, L., et al. New N-arachidonoylserotonin analogues with potential “dual” mechanism of action against pain. J Med Chem 50 6554-6569 (2007).

Size	Global Purchasing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing

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