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JWH 018 N-(5-hydroxypentyl) metabolite Exclusive

Cayman Chemical Item Number 9000855

JWH 018 N-(5-hydroxypentyl) metabolite

See more	Cannabinoids (333) Forensic Science (369) Neuroscience (725) Pain (151)

Description

JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB₂) receptor, derived from the aminoalkylindole WIN 55212-2. The K_i values for binding central cannabinoid (CB₁) and CB₂ receptors are 9.0 and 2.94 nM, respectively, for a CB₁:CB₂ ratio of 3.06.¹ JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. JWH 018 N-(5-hydroxypentyl) metabolite is a major urinary metabolite of JWH 018, characterized by monohydroxylation of the N-alkyl chain.² In urine samples, this metabolite is almost completely glucuronidated.²

1 Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug Alcohol Depend 60 133-140 (2000).

2 Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci Int 200 141-147 (2010).

Formal Name	(1-(5-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)-methanone
Molecular Formula	C₂₄H₂₃NO₂
Formula Weight	357.4
Formulation	A crystalline solid
Purity	≥98%
λ_max	218, 316 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(C1=CN(CCCCCO)C2=C1C=CC=C2)C3=C4C(C=CC=C4)=CC=C3

Background Reading

Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci Int 200 141-147 (2010).

Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug Alcohol Depend 60 133-140 (2000).

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