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5,6-dehydro Arachidonic Acid

Cayman Chemical Item Number 90020

(CAS 58688-54-3)

5,6-dehydro Arachidonic Acid (CAS 58688-54-3)

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Description

5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 µM.1 In guinea pig leukocytes, 5-LO is inhibited by 5,6-dehydro arachidonic acid with an IC50 value of 10 µM.2

1 Kohyama, N., Nagata, T., Fujimoto, S., et al. Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Biosci Biotechnol Biochem 61 347-350 (1997).

2 Sok, D., Han, C., Pai, J., et al. Inhibition of leukotriene biosynthesis by acetylenic analogs. Biochem Biophys Res Commun 107 101-108 (1982).

Formal Name 8Z,​11Z,​14Z-​eicosatrien-​5-​ynoic acid
CAS Number 58688-54-3
Molecular Formula C20H30O2
Formula Weight 302.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)​O

Background Reading

Sok, D., Han, C., Pai, J., et al. Inhibition of leukotriene biosynthesis by acetylenic analogs. Biochem Biophys Res Commun 107 101-108 (1982).

5,6-dehydro Arachidonic Acid is available in the following screening library:

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