Cayman Chemical | Arachidonoyl Ethanolamide | Description • Anandamide; AEA (CAS 94421-68-8)

90050 Arachidonoyl Ethanolamide

Anandamide; AEA (CAS 94421-68-8)

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Arachidonoyl ethanolamide (AEA) is the ethanolamine amide of arachidonic acid, first isolated from porcine brain.¹ AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors.² AEA inhibits the specific binding of [³H]-HU-243 to synaptosomal membranes with a K_i value of 52 nM, compared to 46 nM for Δ⁹-THC.¹

1 Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

2 Felder, C.C., Briley, E.M., Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci USA 90 7656-7660 (1993).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.