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Arachidonoyl-2'-Fluoroethylamide

Cayman Chemical Item Number 90054

2'-fluoro Anandamide; 2'-fluoro AEA (CAS 166100-37-4)

Arachidonoyl-2'-Fluoroethylamide (CAS 166100-37-4)

See more	Receptor Biochemistry (344) Receptor Agonist (161) Neuroscience (725)

Description

Arachidonoyl-2'-fluoroethylamide (2-fluoro AEA) is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution adds considerably increased binding affinity for the CB₁ receptor. It also contributes additional selectivity, in that binding to CB₂ is decreased relative to AEA.¹ However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme.

1 Lin, S., Khanolkar, A.D., Fan, P., et al. Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB₁ and CB₂ cannabinoid receptors and metabolic stability. J Med Chem 41 5353-5361 (1998).

Synonyms	2'-fluoro Anandamide 2'-fluoro AEA
Formal Name	N-(2-fluoroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
CAS Number	166100-37-4
Molecular Formula	C₂₂H₃₆FNO
Formula Weight	349.5
Formulation	A solution in ethanol
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N(CCF)[H])=O

Background Reading

Lin, S., Khanolkar, A.D., Fan, P., et al. Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB₁ and CB₂ cannabinoid receptors and metabolic stability. J Med Chem 41 5353-5361 (1998).

Arachidonoyl-2'-Fluoroethylamide is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing

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