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AM404

Cayman Chemical Item Number 90060

N-(4-hydroxyphenyl)-Arachidonoyl Amide; 4-HPA (CAS 183718-77-6)

AM404 (CAS 183718-77-6)

See more	Cannabinoids (333) Neuroscience (725)

Description

AM404 is an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons. AM404 selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis. It inhibits the transport of AEA with an IC₅₀ of 1 µM in rat neurons and 5 µM in rat astrocytes. In in vivo models, AM404 enhances and prolongs exogenous AEA-induced analgesia at a dose of 10 mg/kg.¹

1 Beltramo, M., Stella, N., Calignano, A., et al. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094-1097 (1997).

Synonyms	N-(4-hydroxyphenyl)-Arachidonoyl Amide 4-HPA
Formal Name	N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetrenamide
CAS Number	183718-77-6
Molecular Formula	C₂₆H₃₇NO₂
Formula Weight	395.6
Formulation	A solution in ethanol
Purity	>98%
λ_max	250 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)Nc1ccc(O)cc1

Background Reading

Kulkarni, P.S., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins 31 1159-1164 (1986).

Beltramo, M., Stella, N., Calignano, A., et al. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094-1097 (1997).

AM404 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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