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S-1 Methanandamide

Cayman Chemical Item Number 90072

(S)-(−)-Arachidonyl-1'-Hydroxy-2'-Propylamide

S-1 Methanandamide

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Description

S-1 methanandamide is a CB1 receptor ligand but is less potent than the C-1 (R) methyl isomer. It inhibits electrically evoked contractions in isolated mouse vasa deferentia with an IC50 value of 230 nM. The binding affinity of S-1 methanandamide for CB1 receptors is less than that of AEA, with a Ki of 175 nM for the displacement of radiolabeled CP 55,940.1

1 Abadji, V., Lin, S., Taha, G., et al. (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem 37 1889-1893 (1994).

Synonyms
  • (S)-(-)-Arachidonyl-1'-Hydroxy-2'-Propylamide
Formal Name N-​(2-​hydroxy-​1S-​methylethyl)-​5Z,​8Z,​11Z,​14Z-​eicosatetraenamide
Molecular Formula C23H39NO2
Formula Weight 361.6
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N([C@@H]​(C)​CO)​[H]​)​=O

S-1 Methanandamide is available in the following screening library:

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Warning This product is not for human or veterinary use.

Related Products

Arachidonoyl Ethanolamide
R-1 Methanandamide
R-2 Methanandamide
S-2 Methanandamide
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