Antioxidant activity has been reported to be a general property of the phenolic components of marijuana. Unlike Δ⁹-THC, cannabidiol can be administered at relatively high doses without undesired toxic or psychological effects.¹ Cannabidiol at a concentration of 10 µM was neuroprotective against both excitatory neurotransmitter (glutamate) and oxidant (hydroperoxide) induced neurotoxicity.²

1 Consroe, P., Laguna, J., Allender, J., et al. Controlled clinical trial of cannabidiol in Huntington’s disease. Pharmacol Biochem Behav 40 701-708 (1991).

2 Hampson, A.J., Grimaldi, M., Axelrod, J., et al. Cannabidiol and (−)Δ⁹-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 95 8268-8273 (1998).

Hampson, A.J., Grimaldi, M., Axelrod, J., et al. Cannabidiol and (−)Δ⁹-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 95 8268-8273 (1998).

Consroe, P., Laguna, J., Allender, J., et al. Controlled clinical trial of cannabidiol in Huntington’s disease. Pharmacol Biochem Behav 40 701-708 (1991).

Cannabidiol is available in the following screening library:

• Cannabinoid Agonist Screening Library (96-Well)

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