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HU-308

Cayman Chemical Item Number 90086

(CAS 256934-39-1)

HU-308 (CAS 256934-39-1)

See more	Forensic Science (369) Neuroscience (725)

Description

The endocannabinoids (ethanolamides and 2-glyceryl esters of unsaturated fatty acids, mainly arachidonate) are ligands for the central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) G-protein coupled receptors.^1,2 HU-308 is a potent, selective agonist for the peripheral CB₂ receptor. The K_i for CB₁ is >10 µM, while the K_i for CB₂ is approximately 20 nM.³ When administered to whole animals, HU-308 elicits hypotensive, analgesic, and anti-inflammatory activity, but none of the behavioral tetrad of psychomotor responses characteristic of the phenolic components of hemp, such as Δ⁹-THC.

1 Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999).

2 Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

3 Hanus, L., Breuer, A., Tchilibon, S., et al. HU-308: A specific agonist for CB₂, a peripheral cannabinoid receptor. Proc Natl Acad Sci USA 96 14228-14233 (1999).

Formal Name	4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-ene-2-methanol
CAS Number	256934-39-1
Molecular Formula	C₂₇H₄₂O₃
Formula Weight	414.6
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCC(C)(C)c1cc(OC)c(c(OC)c1)C1C=C(CO)C2CC1C2(C)C

Background Reading

Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999).

Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

Hanus, L., Breuer, A., Tchilibon, S., et al. HU-308: A specific agonist for CB₂, a peripheral cannabinoid receptor. Proc Natl Acad Sci USA 96 14228-14233 (1999).

HU-308 is available in the following screening library:

Cannabinoid Agonist Screening Library (96-Well)

Size	Global Purchasing
1 mg	See a distributor in your region for pricing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
25 mg	See a distributor in your region for pricing

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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