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Eicosatetraynoic Acid

Cayman Chemical Item Number 90120

ETYA (CAS 1191-85-1)

Eicosatetraynoic Acid (CAS 1191-85-1)

See more	Cyclooxygenase (97) Fatty Acids (267) Inhibitors (493)

Description

ETYA is a nonspecific inhibitor of cyclooxygenases and lipoxygenases.¹ ETYA inhibits human platelet 12-LO and COX-1 with IC₅₀ values of 4 µM and 8 µM, respectively.¹ ETYA is a PPAR ligand which activates PPARα and PPARγ chimeras at concentrations of 10 µM.²

1 Hammarström, S. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta 487 517-519 (1977).

2 Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J₂ metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813-819 (1995).

Synonyms	ETYA
Formal Name	5,8,11,14-eicosatetraynoic acid
CAS Number	1191-85-1
Molecular Formula	C₂₀H₂₄O₂
Formula Weight	296.4
Formulation	White orthorhombic flakes
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCCCCCC(=O)O

Background Reading

Hammarström, S. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta 487 517-519 (1977).

Tobias, L.D., and Hamilton, J.G. The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism. Lipids 14 181-193 (1979).

Downing, D.T., Barve, J.A., Gunstone, F.D., et al. Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthase. Biochim Biophys Acta 280 343-347 (1972).

Kühn, H., Holzhütter, H., Schewe, T., et al. The mechanism of inactivation of lipoxygenases by acetylenic fatty acids. Eur J Biochem 139 577-583 (1984).

Taylor, A.S., Morrison, A.R., and Russell, J.H. Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: Competition with arachidonic acid for esterification. Prostaglandins 29 449-458 (1985).

Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J₂ metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813-819 (1995).

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Eicosatetraynoic Acid is available in the following screening libraries:

Size	Price	Quantity	Subtotal
5 mg	$41.00		$0.00
10 mg	$78.00		$0.00
25 mg	$185.00		$0.00
50 mg	$328.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Related Products

11(Z),14(Z)-Eicosadienoic Acid

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