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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

10(E),12(Z)-Conjugated Linoleic Acid

Cayman Chemical Item Number 90145

10E,12Z-CLA (CAS 2420-56-6)

10(E),12(Z)-Conjugated Linoleic Acid (CAS 2420-56-6)

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Description

Conjugated linoleic acid (CLA) refers to a family of 8 geometric isomers of linoleic acid in which the two double bonds are contiguous. (The predominant form of linoleic acid in nature, 18:ω6, has double bonds at 9 and 12, interrupted by a methylene carbon.) CLA is found in both meat and dairy products, but it is not found to any significant degree in plants. The predominant isomer of CLA in animal tissue is 9Z,11E; smaller amounts of 10E,12Z also occur. Various antioxidant and antitumor activities have been attributed to CLA or its downstream metabolites.1 Reported health benefits of dietary supplementation with CLA have been attributed variously to competitive inhibition of Δ6-desaturase and/or PPARγ activation.2

1 Shultz, T.D., Chew, B.P., Seaman, W.R., et al. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cells. Cancer Lett 63 125-133 (1992).

2 Houseknecht, K.L., Vanden Heuvel, J.P., Moya-Camarena, S.Y., et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat.. Biochem Biophys Res Commun 244 678-682 (1998).

Synonyms
  • 10E,12Z-CLA
Formal Name 10E,​12Z-​octadecadienoic acid
CAS Number 2420-56-6
Molecular Formula C18H32O2
Formula Weight 280.5
Formulation A solution in ethanol
Purity ≥98%
λmax 233 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C=C/CCCCCCCCC(=O)​O

Background Reading

Shultz, T.D., Chew, B.P., Seaman, W.R., et al. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cells. Cancer Lett 63 125-133 (1992).

Houseknecht, K.L., Vanden Heuvel, J.P., Moya-Camarena, S.Y., et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat.. Biochem Biophys Res Commun 244 678-682 (1998).

10(E),12(Z)-Conjugated Linoleic Acid is available in the following screening library:

Size Price Quantity Subtotal
10 mg $14.00 $0.00
25 mg $33.00 $0.00
50 mg $63.00 $0.00
100 mg $112.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

9(E),11(E)-Conjugated Linoleic Acid
Linoleic Acid
Linoleic Acid (peroxide free)

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