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Dihomo-γ-Linolenoyl Ethanolamide

Cayman Chemical Item Number 90235

(CAS 150314-34-4)

Dihomo-γ-Linolenoyl Ethanolamide (CAS 150314-34-4)

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Description

Dihomo-γ-linolenoyl ethanolamide is an endocannabinoid containing dihomo-γ-linoleate in place of the arachidonate moiety of AEA. Dihomo-γ-linolenoyl ethanolamide binds to recombinant human CB1 and CB2 receptors with Ki values of 857 and 598 nM, respectively.1 Its specific role and relative importance as a cannabinergic neurotransmitter has not been elucidated.2

1 Felder, C.C., Joyce, K.E., Briley, E.M., et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48 443-450 (1995).

2 Hanus, L., Gopher, A., Almog, S., et al. Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor. J Med Chem 36 3032-3034 (1993).

Formal Name N-​(2-​hydroxyethyl)-​8Z,​11Z,​14Z-​eicosatrienamide
CAS Number 150314-34-4
Molecular Formula C22H39NO2
Formula Weight 349.6
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)​NCCO

Background Reading

Felder, C.C., Joyce, K.E., Briley, E.M., et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48 443-450 (1995).

Hanus, L., Gopher, A., Almog, S., et al. Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor. J Med Chem 36 3032-3034 (1993).

Dihomo-γ-Linolenoyl Ethanolamide is available in the following screening library:

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