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Dihomo-γ-Linolenic Acid ethyl ester

Cayman Chemical Item Number 90236

Ethyl DGLA

Dihomo-γ-Linolenic Acid ethyl ester

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Description

Dihomo-γ-linolenic acid (DGLA) is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Ethyl DGLA is an esterified version of the free acid which is less water soluble, but more amenable for the formulation of DGLA-containing diets and dietary supplements. DGLA has been advanced as a possible treatment for various inflammatory disorders.1,2 Evening primrose oil is a DGLA-rich nutraceutical which has been advocated for such uses.

1 Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).

2 Schalin-Karrila, M., Mattila, L., Jansen, C.T., et al. Evening primrose oil in the treatment of atopic eczema: Effect on clinical status, plasma phospholipid fatty acids, and circulating blood prostaglandins. Br J Dermatol 117 11-19 (1987).

Synonyms
  • Ethyl DGLA
Formal Name 8Z,​11Z,​14Z-​eicosatrienoic acid,​ ethyl ester
Molecular Formula C22H38O2
Formula Weight 334.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)​OCC

Background Reading

Schalin-Karrila, M., Mattila, L., Jansen, C.T., et al. Evening primrose oil in the treatment of atopic eczema: Effect on clinical status, plasma phospholipid fatty acids, and circulating blood prostaglandins. Br J Dermatol 117 11-19 (1987).

Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).

Dihomo-γ-Linolenic Acid ethyl ester is available in the following screening libraries:

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Warning This product is not for human or veterinary use.

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