Oleic Acid (CAS 112-80-1) || Cayman Chemical

Oleic Acid

Cayman Chemical Item Number 90260

(CAS 112-80-1)

Oleic Acid (CAS 112-80-1)

Description

Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.¹ Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml.¹ fMLF-induced neutrophil aggregation and degranulation is inhibited by 55% and 68%, respectively, using 5 µM oleic acid. This inhibition is comparable to that observed using arachidonic acid under the same conditions.² Oleic acid, whether applied extracellularly (EC₅₀ = ~60 µM) to human platelets or released from membrane phospholipids, causes an increase in intracellular calcium levels.³

1 Wahle, K.W.J., and Peacock, L.I.L. Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. Biochim Biophys Acta 1301 141-149 (1996).

2 Naccache, P.H., Moiski, T.F.P., Volpi, M., et al. Modulation of rabbit neutrophil aggregation and degranulation by free fatty acids. J Leukoc Biol 36 333-340 (1984).

3 Siafaka-Kapadai, A., Hanahan, D.J., and Javors, M.A. Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messenger? J Lipid Mediat Cell Signal 15 215-232 (1997).

Formal Name

9Z-Octadecenoic acid

CAS Number

112-80-1

Molecular Formula

C₁₈H₃₄O₂

Formula Weight

282.5

Formulation

A solution in ethanol

Purity

>98%

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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CCCCCCCC/C=C\CCCCCCCC(=O)O

Background Reading

Naccache, P.H., Moiski, T.F.P., Volpi, M., et al. Modulation of rabbit neutrophil aggregation and degranulation by free fatty acids. J Leukoc Biol 36 333-340 (1984).

Wahle, K.W.J., and Peacock, L.I.L. Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. Biochim Biophys Acta 1301 141-149 (1996).

Siafaka-Kapadai, A., Hanahan, D.J., and Javors, M.A. Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messenger? J Lipid Mediat Cell Signal 15 215-232 (1997).

Size

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500 mg 
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1 g 
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5 g 
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10 g 
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