Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Oleic Acid

Cayman Chemical Item Number 90260

(CAS 112-80-1)

Oleic Acid (CAS 112-80-1)

See more	Fatty Acids (267)

Description

Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.¹ Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml.¹ fMLF-induced neutrophil aggregation and degranulation is inhibited by 55% and 68%, respectively, using 5 µM oleic acid. This inhibition is comparable to that observed using arachidonic acid under the same conditions.² Oleic acid, whether applied extracellularly (EC₅₀ = ~60 µM) to human platelets or released from membrane phospholipids, causes an increase in intracellular calcium levels.³

1 Wahle, K.W.J., and Peacock, L.I.L. Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. Biochim Biophys Acta 1301 141-149 (1996).

2 Naccache, P.H., Moiski, T.F.P., Volpi, M., et al. Modulation of rabbit neutrophil aggregation and degranulation by free fatty acids. J Leukoc Biol 36 333-340 (1984).

3 Siafaka-Kapadai, A., Hanahan, D.J., and Javors, M.A. Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messenger? J Lipid Mediat Cell Signal 15 215-232 (1997).

Formal Name	9Z-Octadecenoic acid
CAS Number	112-80-1
Molecular Formula	C₁₈H₃₄O₂
Formula Weight	282.5
Formulation	A solution in ethanol
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCC/C=C\CCCCCCCC(=O)O

Background Reading

Naccache, P.H., Moiski, T.F.P., Volpi, M., et al. Modulation of rabbit neutrophil aggregation and degranulation by free fatty acids. J Leukoc Biol 36 333-340 (1984).

Wahle, K.W.J., and Peacock, L.I.L. Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. Biochim Biophys Acta 1301 141-149 (1996).

Siafaka-Kapadai, A., Hanahan, D.J., and Javors, M.A. Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messenger? J Lipid Mediat Cell Signal 15 215-232 (1997).

Oleic Acid is available in the following screening libraries:

Size	Price	Quantity	Subtotal
500 mg	$11.00		$0.00
1 g	$13.00		$0.00
5 g	$49.00		$0.00
10 g	$61.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

14(Z)-Eicosenoic Acid

3-Thiatetradecanoic Acid

8,11-Eicosadiynoic Acid

9-Nitrooleate

GPR40 Polyclonal Antibody

N-Oleoyl Dopamine

Oleic Acid-biotin

Oleic Acid-d₁₇

Oleic Acid ethyl ester

Show all 9 Hide all but first 3

Downloads

	Download Product Insert 131 Kb PDF
	Download Material Safety Data Sheet (MSDS) 21 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640