17-Octadecynoic Acid (17-ODA) is a fatty acid analog with an ω-terminal acetylene. It is a suicide inhibitor of leukotriene B₄ 20-hydroxylase and renal CYP450 ω-hydroxylase.^1,2 At a concentration of 10 µM, 17-ODA completely inhibits the bradykinin-dependent transport of sodium chloride in rat TALH cells.²

1 Shak, S., Reich, N.O., Goldstein, I.M., et al. Leukotriene B₄ ω-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J Biol Chem 260 13023-13028 (1985).

2 Grider, J.S., Falcone, J.C., Kilpatrick, E.L., et al. P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. Can J Physiol Pharmacol 75 91-96 (1997).

Grider, J.S., Falcone, J.C., Kilpatrick, E.L., et al. P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. Can J Physiol Pharmacol 75 91-96 (1997).

Shak, S., Reich, N.O., Goldstein, I.M., et al. Leukotriene B₄ ω-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J Biol Chem 260 13023-13028 (1985).

17-Octadecynoic Acid is available in the following screening libraries:

• Fatty Acid Screening Library (96-Well)
• Bio-active Lipid I Screening Library (96-Well)