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17-Octadecynoic Acid

Cayman Chemical Item Number 90270

ODYA; 17-ODA (CAS 34450-18-5)

17-Octadecynoic Acid (CAS 34450-18-5)

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Synonyms
  • ODYA
  • 17-ODA
Formal Name 17-​octadecynoic acid
CAS Number 34450-18-5
Molecular Formula C18H32O2
Formula Weight 280.5
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping WET ICE in continental US; may vary elsewhere
SMILES CCCCCCCCCCCCCCCCCC(=O)​O

Description

17-Octadecynoic Acid (17-ODA) is a fatty acid analog with an ω-terminal acetylene. It is a suicide inhibitor of leukotriene B4 20-hydroxylase and renal CYP450 ω-hydroxylase.1,2 At a concentration of 10 µM, 17-ODA completely inhibits the bradykinin-dependent transport of sodium chloride in rat TALH cells.2

1 Shak, S., Reich, N.O., Goldstein, I.M., et al. Leukotriene B4 ω-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J Biol Chem 260 13023-13028 (1985).

2 Grider, J.S., Falcone, J.C., Kilpatrick, E.L., et al. P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. Can J Physiol Pharmacol 75 91-96 (1997).

Related Articles

Grider, J.S., Falcone, J.C., Kilpatrick, E.L., et al. P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. Can J Physiol Pharmacol 75 91-96 (1997).

Shak, S., Reich, N.O., Goldstein, I.M., et al. Leukotriene B4 ω-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J Biol Chem 260 13023-13028 (1985).

17-Octadecynoic Acid is available in the following screening libraries:

Pricing updated 2010-09-06. Prices are subject to change without notice.

Pricing is for North America only. Other customers should contact a distributor in their region.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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