DHA is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. DHA constitutes as much as 40% of the total PUFA pool in retinal and neuronal membranes.1 Supplementation of dietary DHA using fish oil inhibits the progression of atherosclerosis and delays photoreceptor degeneration in retinitis pigmentosa.2 Neonatal DHA deprivation causes developmental defects and can lead to hypertension in rats.3
1
Salem, N., Kim, H., and Yergey, J.A. Docosahexaenoic acid: Membrane function and metabolism. 263-317(1986).
2
Hoffman, D.R., Uauy, R., and Birch, D.G. Metabolism of ω-3 fatty acids in patients with autosomal dominant retinitis pigmentosa. Exp Eye Res60279-289(1995).
3
Weisinger, H.S., Armitage, J.A., Sinclair, A.J., et al. Perinatal ω-3 fatty acid deficiency affects blood pressure later in life. Nat Med7(3)258-259(2001).
Synonyms
DHA
Cervonic Acid
Formal Name
4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid
CAS Number
6217-54-5
Molecular Formula
C22H32O2
Formula Weight
328.5
Formulation
A solution in ethanol
Purity
≥98%
Stability
1 year
Storage
-20°C
Shipping
Wet ice
in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O
Background Reading
Salem, N., Kim, H., and Yergey, J.A. Docosahexaenoic acid: Membrane function and metabolism. 263-317(1986).
Hoffman, D.R., Uauy, R., and Birch, D.G. Metabolism of ω-3 fatty acids in patients with autosomal dominant retinitis pigmentosa. Exp Eye Res60279-289(1995).
Weisinger, H.S., Armitage, J.A., Sinclair, A.J., et al. Perinatal ω-3 fatty acid deficiency affects blood pressure later in life. Nat Med7(3)258-259(2001).
Docosahexaenoic Acid is available in the following screening
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