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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

R-Palmitoyl-(1-methyl) Ethanolamide

Cayman Chemical Item Number 90353

R-1 PMA (CAS 142128-47-0)

R-Palmitoyl-(1-methyl) Ethanolamide (CAS 142128-47-0)

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Description

Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.1 PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.2 R-Palmitoyl-(1-methyl) ethanolamide is a synthetic analog of PEA which incorporates an (R)-methyl group vicinal to the alcohol on the ethanolamine moiety. The analogous modification to arachidonoyl ethanolamide (AEA) protects the molecule from hydrolysis by fatty acid amide hydrolase. This leads to prolonged duration of action and enhanced potency in vivo.3 R-palmitoyl-(1-methyl) ethanolamide would be expected to show enhancement of the inhibitory action of PEA on mast cells and other cells known to express the CB2 receptor. However, there are no published studies on the use of this compound to date.

1 Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

2 Ganley, O.H., Graessle, O.E., Robinson, H.J., et al. Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin. J Lab Clin Med 51 709-714 (1958).

3 Abadji, V., Lin, S., Taha, G., et al. (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem 37 1889-1893 (1994).

Synonyms
  • R-1 PMA
Formal Name N-​(2-​hydroxy-​1R-​methylethyl)-​hexadecanamide
CAS Number 142128-47-0
Molecular Formula C19H39NO2
Formula Weight 313.5
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCC(=O)​N[C@H]​(C)​CO

Background Reading

Abadji, V., Lin, S., Taha, G., et al. (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem 37 1889-1893 (1994).

Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

Ganley, O.H., Graessle, O.E., Robinson, H.J., et al. Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin. J Lab Clin Med 51 709-714 (1958).

R-Palmitoyl-(1-methyl) Ethanolamide is available in the following screening library:

Size Price Quantity Subtotal
5 mg $22.00 $0.00
10 mg $42.00 $0.00
50 mg $176.00 $0.00
500 mg $1,320.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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