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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

9,12-Octadecadiynoic Acid

Cayman Chemical Item Number 90400

Ro 3-1314 (CAS 2012-14-8)

9,12-Octadecadiynoic Acid (CAS 2012-14-8)

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Description

Ro 3-1314 is an inhibitor of both COX and lipoxygenase.1,2 Ro 3-1314 inhibits ram seminal vesicle COX with a Ki of 0.6 µM.1 It is a more effective inhibitor of COX-1 than of 15-LO, inhibiting 95% and 68%, respectively, of these enzymatic activities when used at a concentration of 48 µM.2

1 Vanderhoek, J.Y., and Lands, W.E.M. Acetylenic inhibitors of sheep vesicular gland oxygenase. Biochim Biophys Acta 296 374-381 (1973).

2 Downing, D.T., Barve, J.A., Gunstone, F.D., et al. Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthase. Biochim Biophys Acta 280 343-347 (1972).

Synonyms
  • Ro 3-1314
Formal Name 9,​12-​octadecadiynoic acid
CAS Number 2012-14-8
Molecular Formula C18H28O2
Formula Weight 276.4
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCCC(=O)​O

Background Reading

Vanderhoek, J.Y., and Lands, W.E.M. Acetylenic inhibitors of sheep vesicular gland oxygenase. Biochim Biophys Acta 296 374-381 (1973).

Downing, D.T., Barve, J.A., Gunstone, F.D., et al. Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthase. Biochim Biophys Acta 280 343-347 (1972).

Hitchcock, M., and Kokolis, N.A. Arachidonic acid metabolism and modulation of in vitro anaphylaxis by 5,8,11,14-eicosatetraynoic acid and 9a,12a-octadecadiynoic acid. Br J Pharmacol 72 689-695 (1981).

9,12-Octadecadiynoic Acid is available in the following screening library:

Size Price Quantity Subtotal
1 mg $61.00 $0.00
5 mg $275.00 $0.00
10 mg $488.00 $0.00
50 mg $2,135.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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FR122047 (hydrate)

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