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90415 5(S),6(R),15(R)-Lipoxin A4
5(S),6(R),15(R)-LXA4; AT-Lipoxin A4
(CAS 171030-11-8)
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Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 5(S),6(R),15(R)-Lipoxin A4 (5(S),6(R),15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid.1,2 5(S),6(R),15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.3,2 The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 5(S),6(R),15(R)-LXA4 to regulate leukocyte function.4
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1
Clària, J., Lee, M.H., Serhan, C.N. Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Mol Med 2 583-596 (1996).
2
Clària, J., Serhan, C.N. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci USA 92 9475-9479 (1995).
3
Fierro, I.M., Colgan, S.P., Bernasconi, G., et al. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: Comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. J Immunol 170 2688-2694 (2003).
4
Chiang, N., Bermudez, E.A., Ridker, P.M., et al. Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proc Natl Acad Sci USA 101(42) 15178-15183 (2004).
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Pricing updated 2010-03-17.
Prices are subject to change without notice.
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