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90420 5(S),14(R)-Lipoxin B4
5(S),14(R)-LXB4
(CAS 98049-69-5)
5(S),14(R)-Lipoxin B4 Workbook Links
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Lipoxins are a series of anti-inflammatory lipid mediators whose brief appearance generally signals the resolution of inflammation. Lipoxin A4 (LXA4) is a potent inhibitor of leukotriene (LT)-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interaction and also blocks PMN migration stimulated by LTB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes.1,2 At a concentration of 10-7 M, LXB4 inhibits PMN migration stimulated by LTB4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of ~3 X 10-10 M.3
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1
Serhan, C.N., Hamberg, M., Samuelsson, B., et al. On the stereochemistry and biosynthesis of lipoxin B. Proc Natl Acad Sci USA 83 1983-1987 (1986).
2
Serhan, C.N., Hamberg, M., Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci USA 81 5335-5339 (1984).
3
Papayianni, A., Serhan, C.N., Brady, H.R. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. J Immunol 156 2264-2272 (1996).
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Pricing updated 2010-03-09.
Prices are subject to change without notice.
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