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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

5(S),14(R)-Lipoxin B4

Cayman Chemical Item Number 90420

5(S),14(R)-LXB4 (CAS 98049-69-5)

5(S),14(R)-Lipoxin B4 (CAS 98049-69-5)

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Description

Lipoxins are a series of anti-inflammatory lipid mediators whose brief appearance generally signals the resolution of inflammation. Lipoxin A4 (LXA4) is a potent inhibitor of leukotriene (LT)-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interaction and also blocks PMN migration stimulated by LTB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes.1,2 At a concentration of 10-7 M, LXB4 inhibits PMN migration stimulated by LTB4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of ~3 X 10-10 M.3

1 Serhan, C.N., Hamberg, M., Samuelsson, B., et al. On the stereochemistry and biosynthesis of lipoxin B. Proc Natl Acad Sci USA 83 1983-1987 (1986).

2 Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci USA 81 5335-5339 (1984).

3 Papayianni, A., Serhan, C.N., and Brady, H.R. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. J Immunol 156 2264-2272 (1996).

Synonyms
  • 5(S),14(R)-LXB4
Formal Name 5S,​14R,​15S-​trihydroxy-​6E,​8Z,​10E,​12E-​eicosatetraenoic acid
CAS Number 98049-69-5
Molecular Formula C20H32O5
Formula Weight 352.5
Formulation A solution in ethanol
Purity >95%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​C(O)​\C=C\C=C\C=C\C=C/[C@@H]​(O)​CCCC(=O)​O

Background Reading

Baer, A.N., Costello, P.B., and Green, F.A. Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells. Biochim Biophys Acta 1085 45-52 (1991).

Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci USA 81 5335-5339 (1984).

Papayianni, A., Serhan, C.N., and Brady, H.R. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. J Immunol 156 2264-2272 (1996).
Size Price Quantity Subtotal
25 µg $213.00 $0.00
50 µg $405.00 $0.00
100 µg $767.00 $0.00
500 µg $3,408.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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