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O-11

Cayman Chemical Item Number 90510

11-Oxatetradecanoic Acid (CAS 119290-12-9)

O-11 (CAS 119290-12-9)

See more	Fatty Acids (267) Oxylipins (226) Immunology (181) Infectious Disease (64)

Description

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50 of less than 1 µM in a cell culture assay.^1,2 The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.¹ O-11 exhibits essentially no anti-fungal activity when assayed using C. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.³

1 Doering, T.L., Raper, J., Buxbaum, L.U., et al. An analog of myristic acid with selective toxicity for African trypanosomes. Science 252 1851-1854 (1991).

2 Doering, T.L., Lu, T., Werbovetz, K.A., et al. Toxicity of myristic acid analogs toward African trypanosomes. Proc Natl Acad Sci USA 91 9735-9739 (1994).

3 Langner, C.A., Lodge, J.K., Travis, S.J., et al. 4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. J Biol Chem 267(24) 17159-17169 (1992).

Synonyms	11-Oxatetradecanoic Acid
Formal Name	10-propoxy-decanoic acid
CAS Number	119290-12-9
Molecular Formula	C₁₃H₂₆O₃
Formula Weight	230.3
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCOCCCCCCCCCC(=O)O

Background Reading

Doering, T.L., Lu, T., Werbovetz, K.A., et al. Toxicity of myristic acid analogs toward African trypanosomes. Proc Natl Acad Sci USA 91 9735-9739 (1994).

Doering, T.L., Raper, J., Buxbaum, L.U., et al. An analog of myristic acid with selective toxicity for African trypanosomes. Science 252 1851-1854 (1991).

Langner, C.A., Lodge, J.K., Travis, S.J., et al. 4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. J Biol Chem 267(24) 17159-17169 (1992).

O-11 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
500 µg	$33.00		$0.00
1 mg	$63.00		$0.00
5 mg	$264.00		$0.00
10 mg	$462.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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Myristic Acid ethyl ester

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Oleic Acid

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