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Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.
COX-2 Inhibitors - Still the best answer for inflammatory pain?
There is renewed interest in COX inhibitors not only for inflammation, but also for other indications such as cancer chemoprevention and antithrombosis. Cayman has COX inhibitors that span the selectivity spectrum, from highly COX-1 selective to many thousand-fold COX-2 selective (see CAY10404). We can work together with you to customize a COX inhibitor with the best activity/selectivity profile to suit your needs.
| Item № | Inhibitor | IC50 COX-1 (µM) | IC50 COX-2 (µM) | Selectivity Ratio (COX-1/COX-2) |
|---|---|---|---|---|
| 70270 | Indomethacin | 0.15 (human) | 2.39 (human) | 0.063 |
| 70250 | (±)- |
0.04 (human) | 0.51 (human) | 0.078 |
| 70290 | (S)- |
0.6 (human) | 2 (human) | 0.3 |
| 70680 | Diclofenac (sodium salt) | 0.9 (human) | 1.5 (human) | 0.6 |
| 70280 | (±)- |
2.6 (human) | 1.53 (human) | 1.7 |
| 70210 | CAY10404 | >500 (ovine) | <0.001 (ovine) | >500000 |
Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA
Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640
Copyright 2012 Cayman Chemical Company
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