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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Tyrosine Kinase Inhibitors

Natural Order Item № Product Image Target Effective Concentration Plain Text Name
1 10010568 AG-370
  • PDGFR Kinase
  • EGFR
  • IC50 = 20 μM in human bone marrow fibroblasts
  • IC50 = 820 μM
 ag-370
2 10010311 AG-490
  • Jak-2
  • 5 μM blocks growth of pre-B acute leukemia (ALL) cells
 ag-490
3 10010242 AG-494
  • EGFR Kinase
  • IC50 = 1 μM in HT- 22 cells
 ag-494
4 10010243 AG-825
  • Her-2/neu
  • EGFR
  • PDGFR
  • IC50 = 0.35 µM
  • IC50 = 19 µM
  • IC50 = 40 µM
 ag-825
5 10010242 AG-494
  • EGFR kinase
  • IC50 = 1 µM in HT-22 cells
 ag-494
6 10010243 AG-825
  • Her-2/neu
  • EGFR
  • PDGFR
  • IC50 = 0.35 μM
  • IC50 = 19 μM
  • IC50 = 40 μM
 ag-825
7 10005167 Genistein
  • Tyrosine-phosphorylation of histone H2B
 genistein
8 13166 Gefitinib
  • EGFR Kinase
  • IC50 = 0.2 nM-0.4 μM in various cancer cell lines
 gefitinib
9 10008131 JNJ-10198409
  • PDGF-BB tyrosine kinase
  • IC50 = 4.2 nM
 jnj-10198409
10 10010265 LFM-A13
  • PDGF-BB tyrosine kinase
  • IC50 = 4.2 nM
 lfm-a13
11 10010265 LFM-A13
  • BTK and Polo-like kinase
  • IC50 = 2.5 μM
 lfm-a13
12 10010422 Nilotinib
  • Bcr/Abl Tyrosine Kinase
  • IC50 = 15 nM in wild-type Bcr/Abl
 nilotinib
13 10010309 RG-13022
  • EGFR kinase
  • IC50 = 1 µM in HT-22 cells
 rg-13022
14 10010310 RG-14620
  • EGFR kinase
  • IC50 = 3 µM in HT-22 cells
 rg-14620
15 10010248 AG-17
  • EGFR kinase
  • IC50 = 460 µM in human epidermoid carcinoma A431 cells
 ag-17
16 10010300 AG-18
  • EGFR kinase
  • IC50 = 35 µM in human epidermoid carcinoma A431 cells
 ag-18
17 10010312 AG-82
  • EGFR kinase
  • IC50 = 3 µM in human epidermoid carcinoma A431 cells
 ag-82
18 10010313 AG-99
  • EGFR kinase
  • IC50 = 10 µM in human epidermoid carcinoma A431 cells
 ag-99
19 10010314 AG-213
  • EGFR kinase
  • IC50 = 2.4 µM in human epidermoid carcinoma A431 cells
 ag-213
20 10010315 AG-183
  • EGFR kinase
  • IC50 = 0.8 µM in human epidermoid carcinoma A431 cells
 ag-183
21 10010592 AG-1296
  • PDGFR Kinase
  • IC50 = 0.4 μM (both in vitro and in Swiss 3T3 cells)
 ag-1296
22 10010238 Erbstatin Analog
  • EGFR Kinase
  • IC50 = 0.14 μg/ml
 erbstatin-analog
23 10010329 Lavendustin C
  • EGFR Kinase
  • IC50 = 0.012 μM
 lavendustin-c
24 10010568 AG-370
  • PDGFR Kinase
  • EGFR Kinase
  • IC50 = 20 μM
  • IC50 = 820 μM
 ag-370
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Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

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