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Tyrosine Kinase Inhibitors

Natural Order	Item №	Product	Target	Effective Concentration	Plain Text Name
1	10010568	AG-370	PDGFR Kinase EGFR	IC₅₀ = 20 μM in human bone marrow fibroblasts IC₅₀ = 820 μM	ag-370
2	10010311	AG-490	Jak-2	5 μM blocks growth of pre-B acute leukemia (ALL) cells	ag-490
3	10010242	AG-494	EGFR Kinase	IC₅₀ = 1 μM in HT- 22 cells	ag-494
4	10010243	AG-825	Her-2/neu EGFR PDGFR	IC₅₀ = 0.35 µM IC₅₀ = 19 µM IC₅₀ = 40 µM	ag-825
5	10010242	AG-494	EGFR kinase	IC₅₀ = 1 µM in HT-22 cells	ag-494
6	10010243	AG-825	Her-2/neu EGFR PDGFR	IC₅₀ = 0.35 μM IC₅₀ = 19 μM IC₅₀ = 40 μM	ag-825
7	10005167	Genistein		Tyrosine-phosphorylation of histone H2B	genistein
8	13166	Gefitinib	EGFR Kinase	IC₅₀ = 0.2 nM-0.4 μM in various cancer cell lines	gefitinib
9	10008131	JNJ-10198409	PDGF-BB tyrosine kinase	IC₅₀ = 4.2 nM	jnj-10198409
10	10010265	LFM-A13	PDGF-BB tyrosine kinase	IC₅₀ = 4.2 nM	lfm-a13
11	10010265	LFM-A13	BTK and Polo-like kinase	IC₅₀ = 2.5 μM	lfm-a13
12	10010422	Nilotinib	Bcr/Abl Tyrosine Kinase	IC₅₀ = 15 nM in wild-type Bcr/Abl	nilotinib
13	10010309	RG-13022	EGFR kinase	IC₅₀ = 1 µM in HT-22 cells	rg-13022
14	10010310	RG-14620	EGFR kinase	IC₅₀ = 3 µM in HT-22 cells	rg-14620
15	10010248	AG-17	EGFR kinase	IC₅₀ = 460 µM in human epidermoid carcinoma A431 cells	ag-17
16	10010300	AG-18	EGFR kinase	IC₅₀ = 35 µM in human epidermoid carcinoma A431 cells	ag-18
17	10010312	AG-82	EGFR kinase	IC₅₀ = 3 µM in human epidermoid carcinoma A431 cells	ag-82
18	10010313	AG-99	EGFR kinase	IC₅₀ = 10 µM in human epidermoid carcinoma A431 cells	ag-99
19	10010314	AG-213	EGFR kinase	IC₅₀ = 2.4 µM in human epidermoid carcinoma A431 cells	ag-213
20	10010315	AG-183	EGFR kinase	IC₅₀ = 0.8 µM in human epidermoid carcinoma A431 cells	ag-183
21	10010592	AG-1296	PDGFR Kinase	IC₅₀ = 0.4 μM (both in vitro and in Swiss 3T3 cells)	ag-1296
22	10010238	Erbstatin Analog	EGFR Kinase	IC₅₀ = 0.14 μg/ml	erbstatin-analog
23	10010329	Lavendustin C	EGFR Kinase	IC₅₀ = 0.012 μM	lavendustin-c
24	10010568	AG-370	PDGFR Kinase EGFR Kinase	IC₅₀ = 20 μM IC₅₀ = 820 μM	ag-370

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Tyrosine Kinase Inhibitors

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