Screening Libraries || Cayman Chemical

Cayman Chemical offers a variety of chemical libraries, useful for drug discovery and development, including plates rich in prostaglandin isoforms such as PGF-series, PGD/PGE-series, PGA/PGJ-series and miscellaneous prostanoid analogs. Screening libraries focused on fatty acids, kinase inhibitors, and epigenetic compounds are also available. Much of Cayman’s collection of high purity bio-active lipids, including prostaglandins, isoprostanes, thromboxanes, leukotrienes, lipoxins, endocannabinoids, and phosphoinositols are included in smaller (219 compound) and larger (846 compound) screening libraries.

Cayman screening libraries are available in DMSO in a 96-well format. The libraries are produced from our inventory of high-quality and high-purity compounds. Any potential screening hit may be purchased individually for activity confirmation and further analysis. Many items are also available in bulk quantities or on a custom basis at a reasonable cost.

In addition to the commercially available plates, Cayman is willing to produce custom libraries from the Cayman compound collection of over 3,000 molecules with the desired format and specifications. Structural information for our diverse collection of compounds is available free of charge for download and may be used for virtual screening and hit-seeking.

Prostaglandin Screening Library I (96-Well)

This screening plate contains a wide range of prostaglandins in the “F-series” configuration (9,11-hydroxy prostaglandins) as 2 mM solutions in DMSO. It includes 86 compounds including isoprostanes, 8-iso, dinor, and tetranor derivatives, and latanoprost, travoprost, and bimatoprost analogs.

Concentration	2 mM
Available well volume	50, 100, 200 µL
Number of active wells	86 compounds

Prostaglandin Screening Library II (96-Well)

This screening plate contains wide range prostaglandins in the “D and E-series” configuration (9-keto, 11-keto, 9-hydroxy, and 11-hydroxy prostaglandins) as 2 mM solutions in DMSO. It includes 70 compounds including prostaglandin metabolites, ethanolamides, and other potent analogs of prostaglandin D₂ and prostaglandin E₂.

Concentration	2 mM
Available well volume	50, 100, 200 µL
Number of active wells	70 compounds

Prostaglandin Screening Library III (96-Well)

This screening plate contains wide range prostaglandins in the “A and J-series” as 2 mM solutions in DMSO. It includes 79 compounds including thromboxanes, lactones,stable PGH and prostacylin mimics, metabolites and potent analogs of prostaglandin A₂ and prostaglandin J₂.

Concentration	2 mM
Available well volume	50, 100, 200 µL
Number of active wells	79 compounds

Fatty Acid Screening Library (96-Well)

This screening plate contains a variety of fatty acids with diverse biological activities as 2 mM solutions in DMSO. It includes 84 of the most commonly-ordered fatty acids, including arachidonic, linoleic, eicosapentaenoic, stearic, α- and γ-linolenic, oleic, and palmitic acids. Also includes some unusual fatty acids, including 9-thiastearic acid, 2-hydroxymyristic acid, AUDA, and CUDA.

Concentration	10 mM
Available well volume	50, 100, 200 µL
Number of active wells	84 compounds

Kinase Screening Library (96-Well)

This screening plate contains a variety of specific and non-specific kinase inhibitors as a 10 mM solution in DMSO. It includes 64 compounds including PD 0325901 (dual specific threonine/tyrosine kinase inhibitor), U-0126 (selective MAP kinase inhibitor), SB 203580 (p38 MAPK inhibitor), and LY294002 (PI3K inhibitor).

Concentration	10 mM
Available well volume	100 µL
Number of active wells	64 compounds

Bio-active Lipid I Screening Library (96-Well)

This screening library consists of 11 plates and contains 928 compounds that include prostaglandins, thromboxanes , cannabinoids, D-myo-inositol-phosphates, phosphatidylinositol-phosphates, sphingolipids, inhibitors, receptor agonists and antagonists, ceramide derivatives, and several other complex polyunsaturated fatty acids. This collection is ideal for prostanoid or other G protein-coupled receptor screening, target validation, secondary screening, validating new assays and for routine pharmacological applications. The library is provided in a 96-well format as 1.0 mM solutions in DMSO in 100µL or 500µL/well.

Concentration	1 mM
Available well volume	100, 500 µL
Number of active wells	928 compounds (11 plates)

Bio-active Lipid II Screening Library (96-Well)

This screening library consists of 3 plates and contains 240 compounds that include prostaglandins, isoprostanes, thromboxanes, leukotrienes, lipoxins and several other complex polyunsaturated fatty acids. This collection is deal for prostanoid or other G protein-coupled receptor screening, target validation, secondary screening, validating new assays and for routine pharmacological applications. The library is provided in a 96-well format as 0.1 mM solutions in DMSO in 100µL/well.

Concentration	0.1 mM
Available well volume	100 µL
Number of active wells	240 compounds (3 plates)

Epigenetics Screening Library (96-Well)

This screening library contains 54 small molecules that are known to modulate the activity of a variety of epigenetic ‘writers and erasers’, including methyltransferases, demethylases, histone acetyltransferases, and histone deacetylases. Also represented in the library are inhibitors of epigenetic ‘reader’ proteins, such as acetylated histone binding proteins. The compounds are supplied in a 96-well Matrix tube rack format as 10mM stocks in DMSO. The composition of the library will always vary somewhat depending upon our inventory.

Concentration	- mM
Available well volume	- µL
Number of active wells	54 compounds

Prostaglandin Screening Library I (96-Well)	Prostaglandin Screening Library II (96-Well)	Prostaglandin Screening Library III (96-Well)	Fatty Acid Screening Library (96-Well)	Kinase Screening Library (96-Well)	Bio-active Lipid I Screening Library (96-Well)	Bio-active Lipid II Screening Library (96-Well)	Epigenetics Screening Library (96-Well)
Item № 10501	Item № 10502	Item № 10503	Item № 10504	Item № 10505	Item № 10506	Item № 10507	Item № 11076

Screening Libraries