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Research Area · Drug Discovery

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Item Number Product Sizes & Pricing CAS Purity Image Exclusive Introduction Date Mojo Plain Text Name Synonyms Keywords Interest
10385 1'-Hydroxymidazolam 59468-90-5 ≥95% 2010-04-21 16.977900552486 1-hydroxymidazolam Ro 21-6347 79683-62-8 81877-60-3 138614-39-8 SPIBIO SPI Bio α-Hydroxymidazolam CYP3A CYP 3A benzodiazepine derivatives metabolism 16.977900552486
10386 1'-Hydroxymidazolam β-D-Glucuronide 81256-81-7 ≥98% 2010-04-22 16.977900552486 1-hydroxymidazolam-d-glucuronide SPIBIO SPI Bio oxidative metabolism midazolam derivatives CYP3A CYP 3A benzodiazepine 16.977900552486
10008041 20S Proteasome Assay Kit - 2008-02-12 96.923607734806 20s-proteasome-assay-kit assays fluorescence fluorescent fluorometric cell-based assay cell based assay cba 96.923607734806
13233 2,4-Dimethylthiazole-5-Carboxylic Acid 53137-27-2 ≥98% 2009-06-03 0E-12 2-4-dimethylthiazole-5-carboxylic-acid Thiazoles drugs discovery heterocyclic building blocks 0E-12
13231 4-Methylbenzamide oxime 19227-13-5 ≥98% 2009-07-01 0.018784530386 4-methylbenzamide-oxime p-Toylamideoxime drug discovery oximes 0.018784530386
10009856 7-AAD Cell Viability Assay Kit - 2008-10-29 22.474749868935 7-aad-cell-viability-assay-kit 7-Amino Actinomycin D Cell Viability Kit kits 7AAD measurement cells fixation blocking cytoxicity effects environmental toxins drug fluorescence fluorescent cell-based assays cell based assay cba 22.474749868935
10006908 Adipogenesis Assay Kit - 2006-08-18 97.724003444898 adipogenesis-assay-kit obese obesity cells cycle differentiation inhibits inhibitors inhibition adipocytes cancers origin 3T3-L1 model drug screening adipokines endocrinology cell-based assays cell based assay cba 97.724003444898
10009381 Adipolysis Assay Kit - 2007-07-30 52.117738993721 adipolysis-assay-kit obese obesity cells cycle differentiation inhibits inhibitors inhibition adipocytes cancers origin 3T3-L1 model drug screening adipokines lipolysis 3T3L1 kits assays FFA adipocytes endocrinology cell-based assay cell based assay cba 52.117738993721
600140 Autophagy/Cytotoxicity Dual Staining Kit - 2009-07-14 80.606732438832 autophagy-cytotoxicity-dual-staining-kit assays kits measuring measurement MDC cell-based autophagy cells cytotoxicity staining autofluorescent autofluorescence substances multilamellar body bodies ions trapping mechanisms membranes lipids probes autophagic vacuoles cultured degradation digestion intracellular lysosomes organelles misfolded proteins microorganisms cytoplasms double membranes autophagosomes autolysosomes homeostasis dysregulation cancers infections aging degenerative diseases stress death apoptosis 80.606732438832
700580 Autotaxin Inhibitor Screening Assay Kit - 2011-06-28 16.120036832412 autotaxin-inhibitor-screening-assay-kit ATX Inhibitor Screening Assay Kit kits assays measures measurements Ectonucleotides Pyrophosphatase-2 ENPP-2 Lysopholipases D hydrolysis lysophosphatidylcholines LPC lysophosphatidic acid LPA lipids mediators G protein-coupled receptors GPCRs neurogenesis angiogenesis smooth-muscles contraction platelets aggregations wounds healings ATX-LPA signaling tumors progression inflammation serums proteolytically peptides proteins N-glycosylation Asn53 Asn410 adipocytes cerebrospinal fluid multiple sclerosis livers fibrosis cancers genes chips analysis upregulated metastatic inhibits inhibition human 16.120036832412
600070 BACE Inhibitor Screening Assay Kit - 2009-03-26 16.731740331491 bace-inhibitor-screening-assay-kit β-Secretase Inhibitor Screening Assay Kit inhibitors inhibition inhibits assays kits β-sites .beta.-sites b-sites APP cleaving enzymes β-amyloids .beta.-amyloids b-amyloids peptides Ab A.beta. brain neurodegeneration Alzheimer's Diseases AD proteolytic cleavages precursors β-secretases b-secretases γ-secretases .gamma.-secretases g-secretases membranes aspartic C-terminal C-terminus fragments proteolysis therapeutics therapy cascade pathogenesis mice mouse murine transgenics cholinergic dysfunctions HIV humans fluorescents fluorescences fluorometer assays 16.731740331491
13230 Benzamideoxime 613-92-3 ≥98% 2009-07-28 0.023480662983 benzamideoxime NSC 13999 drugs discovery benzamidoximes 0.023480662983
10009853 CFSE Cell Division Assay Kit - 2010-01-15 63.844708882277 cfse-cell-division-assay-kit derivative carboxyfluorescein diacetate, succinimidyl ester CFDA-SE cells proliferation growth factors receptors surfaces signaling molecules transcription factors DNA deoxyribonucleases proteins divisions cascades human pathological diseases cancers cell-tracing fluorescent fluorescence dyes proliferative activity parent generations daughter acetate groups molecules cleaved background unstained staining CFSE-labeled radioactivity radioactive labeling divisions inductions inhibitors inhibits inhibitions in vitro models flow cytometry fluorochromes fluorescein 63.844708882277
760111 Colorimetric COX (ovine) Inhibitor Screening Assay Kit - 185.450171561500 colorimetric-cox-ovine-inhibitor-screening-assay-kit cyclooxygenases cox-1 cox-2 pghs-1 pghs-2 cox1 cox2 pghs1 pghs2 prostaglandins synthases synthase-1 synthase-2 inhibition inhibitors assays screens peroxidase colorimetrically analysistools:eia 185.450171561500
700100 COX Fluorescent Inhibitor Screening Assay Kit - 2008-07-08 118.577300710339 cox-fluorescent-inhibitor-screening-assay-kit Cyclooxygenase Fluorescent Inhibitor Screening Assay Kit cyclooxygenases synthases enzymes cox-1 cox1 cox-2 cox2 prostaglandins PGs synthase-1 synthase-2 pghs-1 pghs1 pghs-2 pghs2 assays kits peroxidase activity cellular homeostasis antiinflammatory NSAIDs nonsteroidal anti-inflammatory drugs fluorescence human recombinant ovine isozyme-specific inhibits inhibitors inhibition ADHP 10-acetyl-3,7-dihydroxyphenoxazine resorufin 118.577300710339
560131 COX Inhibitor Screening Assay Kit - 239.017309632476 cox-inhibitor-screening-assay-kit enzyme immunoassays kits measures EIAs ELISAs COX1 COX-1 COX2 COX-2 PGHS1 pghs-1 pghs2 pghs-2 prostaglandin synthases inhibitors cyclooxygenase analysistools:eia assays cox inhibitior kit 239.017309632476
560101 COX (ovine) Inhibitor Screening Assay Kit - 131.589773743751 cox-ovine-inhibitor-screening-assay-kit enzyme immunoassays kits measures EIAs ELISAs COX1 COX-1 COX2 COX-2 PGHS1 pghs-1 pghs2 pghs-2 prostaglandin synthases inhibitors cyclooxygenases sheep screens assays cox inhibitior kit 131.589773743751
600670 CYP1A1/2 Induction STEP Reporter Assay Kit (Luminescence) Exclusive New - ✓ 2012-05-23 98.725686222924 cyp1a1-2-induction-step-reporter-assay-kit-luminescence kits assays measures measurements cytochromes P450s CYP450 CYPs heme-thiolates monoxygenases metabolizes endogenous compounds xenobiotics pollutants environmentals drugs enzymes metabolisms medications induction pharmacokinetics drug-drug interactions co-administered therapeutics CYP1A2 CYP2C19 CYP2C9 CYP2D6 CYP3A4 CYP1A1 CYP1A2 detoxification metabolic polycyclic aromatic hydrocarbons cigarette smoke combustion arylamines heterocyclic amines char-broiled meats intermediates mutagenics carcinogenics inhibits toxicity low efficacy development primary humans hepatocytes livers cells tissues hepatocyte-like CBAs cell-based assays kits measures measurements cultured lines transfected genes promoter/enhancer sequences high-throughput assessments Surface transfection Expression protocols solid phases transient originus, Inc. incorporated University of Michigan U M US patents USPT 6897067 6902933 7056741 complexes DNA deoxyribonucleases proteins adherent endocytosis solution-phase plasmids secreted alkaline phosphatases SEAP inducer-activated transcription factors TFs signals signaling culture mediums luminescence-based 3-MC 3MC 98.725686222924
700390 Demethylase (Jumonji-type) Activity Assay Kit - 2010-05-26 28.154262474787 demethylase-jumonji-type-activity-assay-kit kits assays measures measurements histones nucleoproteins chromatins DNA deoxynucleic acids eukaryotic nucleus nucleosomal H3 H4 H2B H2A octamers amino termini acetylation phosphorylation ubiquitination methylation replication repair transcriptional activation repression dysregulation tumors suppressor genes cancers inhibitors enzymes catalyzes epigenetic marks methyls lysines arginines residues demethylases 1 JMJC JHDM1 JHDM2 JHDM3 JARID1 UTX/UTY cupin 2-oxoglutarate 2OG iron Fe(II) oxygenases hydroxylation JMJD2A JMJD2B JMJD2C JMJD2D JMJD2E JMJD2F fluorescence-based fluorescent cells lysates formaldehydes peptides substrates oxidation/decarboxylation acetoacetanilides ammonia H3K9(Me)3 28.154262474787
700210 DPP (IV) Inhibitor Screening Assay Kit - 2009-05-27 105.254259921503 dpp-iv-inhibitor-screening-assay-kit Dipeptidyl exopeptidases IV DPPIV DPP4 enzymes CD26 cluster of differentiation T-cells activation antigens adenosine deaminase complexing 2 membrane-bound glycoproteins immune regulation signal transduction apoptosis kidneys small intestines placentas humans serums seminal fluids proteolytic derivatives serines X-prolines X-alanines dipeptides N-terminus N-terminal polypeptides growth factors chemokines neuropeptides vasoactive inhibitors inhibits inhibition oral antidiabetic agents glucose homeostasis glucoregulatory hormones glucose-dependent insulinotropics GIP glucagon-like peptide-1 GLP-1 gastric therapeutics Type 2 tumors cancers markers neoplasms assays kits measures measurements fluorescences fluorescent fluorogenics substrates Gly-Pro-Aminomethylcoumarin AMC 105.254259921503
600340 EP2 Receptor (rat) STEP Reporter Assay Kit (Luminescence) Exclusive - ✓ 2010-09-20 33.266108041743 ep2-receptor-rat-step-reporter-assay-kit-luminescence Prostaglandin E2 Receptor 2; PGE2 Receptor 2 prostaglandins E2 PGE2 prostanoids G protein-coupled receptors GPCRs EP1 EP3 EP4 signal transduction tissues regulation cells mediates cAMP cyclic messenger pathways mucosal protection gastrointestinal secretions motility immunity inflammation mice mouse murine tumors cancers cancer-associated immunodeficiency dendritic-cell differentiation in vitro neuroprotective NMDA toxicity oxygen glucose deprivation agonists antagonists therapeutics Surface transfection and expression protocols solid phase transient transfection technology originus patents USPT US6897067 US6902933 US7056741 US 6897067 6902933 7056741 DNA deoxyribonucleases adherent cells receptor-mediated endocytosis solution-phase co-transfection plasmids secretory alkalines phosphatases substrates SEAP proteins lipids signal transduction luminescence-based cell-based assays kits CBAs high-throughput screening 33.266108041743
600350 EP4 Receptor (rat) STEP Reporter Assay Kit (Luminescence) - 2010-11-04 27.996518460054 ep4-receptor-rat-step-reporter-assay-kit-luminescence PGE2 Receptor 4; Prostaglandin E2 Receptor 4 prostaglandins E2 PGE2 prostanoids G protein-coupled receptors GPCRs EP1 EP2 EP3 signal transduction tissues regulation cells intestines lungs kidneys thymus brains uterus mediates cAMP cyclic messenger pathways PtdIns phosphatidylinositols 3-kinases Gi mediates relaxation smooth muscles gastric acid secretions intestinal epithelial transportation adrenal aldosterone uterine immunity inflammation mice mouse murine colon tumors cancers cancer-associated carcinogenesis in vivo neuroprotective NMDA neuroprotective excitotoxic brain injury agonists antagonists therapeutics Surface transfection and expression protocols solid phase transient transfection technology originus patents USPT US6897067 US6902933 US7056741 US 6897067 6902933 7056741 DNA deoxyribonucleases adherent cells receptor-mediated endocytosis solution-phase co-transfection plasmids secretory alkalines phosphatases substrates SEAP proteins lipids signal transduction luminescence-based cell-based assays kits CBAs high-throughput screening 27.996518460054
11076 Epigenetics Screening Library (96-Well) - 2011-11-09 25.669649126438 epigenetics-screening-library-96-well epigenetics libraries screens 25.669649126438
13232 ethyl-2,4-dimethyl-Thiazole-5-Carboxylate 7210-77-7 ≥98% 2009-06-03 0E-12 ethyl-2-4-dimethyl-thiazole-5-carboxylate thiazole drugs discovery heterocycle building blocks 0E-12
10005196 FAAH Inhibitor Screening Assay Kit - 2008-09-05 96.643796369377 faah-inhibitor-screening-assay-kit Fatty Acid Amide Hydrolase Inhibitor Screening Assay Kit neurochemistry neuroscience endocannabinoids lipid signaling regulatory arachidonoylethanolamides AEAs 2-arachidonoyl glycerol 2-AG G Protein Coupling Receptors GPCRs CB1 motor controls cognition emotional responses homeostasis CB2 peripheral tissues modulators autonomic nervous systems immune microcirculation enzymes fatty acids amides hydrolases monoacylglycerols lipases MGL MAGL serines inhibitors pain obesity neurological diseases agonists fluorescence-based screening hydrolyzes AMC-arachidonoyl 7-amino-4-methylcoumarin fluorophores assays kits 96.643796369377
700310 Free Fatty Acid Assay Kit - 2010-09-08 193.542559351549 free-fatty-acid-assay-kit FFA kits assays measures measurements acids triglycerides intestines hydrolyzed glycerols enzymes pancreas pancreatic lipases intestinal liposomes capillaries lymph systems blood plasmas serums hepatocytes adipocytes muscles fibers oxidized sugars glucagon fats proteins albumin FFA skeletal skeletons hearts livers pathophysiological obesity insulin resistance type 2 II diabetes pathogenesis insulin-stimulated peripheral glucose uptake beta cells oxidative stressproinflammatory effects NFκB nuclear factors inflammation resistances metabolic urine enzymatic reactions Acyl CoA synthetase ACS acylation coenzymes oxidases ACOD hydrogen peroxides H2O2 horseradish peroxidases HRP 10-aceyl-3,7-dihydroxyphenozazine ADHP fluorescence fluorescent resorufins 193.542559351549
600450 Glycolysis Cell-Based Assay Kit Exclusive - ✓ 2011-08-18 111.060715804774 glycolysis-cell-based-assay-kit CBAs assays kits measures colorimetric colorimetric-based L-lactate culture media mediums cellular metabolic pathways glucose metabolisms cells ATP adenosines triphosphates oxygen exercise erythrocytes mitochondria glucoeogenesis intracellular molecules amino acids insulin glycolytic neurons aerobic energy muscles anaerobic cancers lactate pyruvate tricarboxylic acids cycles oxidizes carbon dioxide CO2 water H2O tumor aggressiveness embryonic stem activity hypoxia-inducible transcriptional factors HIF-1 extracellular inhibition inhibits inhibitors chemotherapeutic strategies strategy metabolomic drugs discovery anticancer 111.060715804774
10006515 HAT Inhibitor Screening Assay Kit - 2006-12-06 14.105470800027 hat-inhibitor-screening-assay-kit Histone Acetyltransferase Inhibitor Screening Assay Kit therapeutics histones p300/CBP-Associated Factors pCAF GNAT GCN5-related N-acetyltransferases acetylates lysines N-terminal terminus tails H3 H4 tumors suppressor genes PTEN human cancers apoptosis fluorescence fluorescent inhibitors fluorometric assays 14.105470800027
10011564 HDAC1 Inhibitor Screening Assay Kit - 2008-04-10 31.288852528686 hdac1-inhibitor-screening-assay-kit HDAC 1 histones deacetylases lysines residues chromatin condensation transcriptional repression fluorescence deacetylation fluorescent inhibits inhibition enzymes license:cyclex fluorometric assays cancer 31.288852528686
700230 HDAC8 Inhibitor Screening Assay Kit - 2009-05-15 21.721975138121 hdac8-inhibitor-screening-assay-kit Histone Deacetylase 8 Inhibitor Screening Assay Kit histone deacetylases inhibits inhibitors inhibition angiogenesis cycling apoptosis differentiation tumors proliferation anticancers genes epigenetic trichostatin A human class I tissues nucleus cytosolic smooth muscle neuroblastoma pathogenesis kits assays measures measurement fluorescent fluorescence-based 21.721975138121
600150 HDAC Cell-Based Activity Assay Kit - 2009-11-09 26.370505361597 hdac-cell-based-activity-assay-kit Histone Deacetylase Cell-Based Activity Assay Kit assays kits measuring measurement histones deacetylases lysines residues chromatin condensation transcriptional repression fluorescence deacetylation fluorescent inhibits inhibition enzymes fluorometric assays cancer modulators whole cells proteins lysine-specific HDAC1 homogenous inhibitor/activator TSA 26.370505361597
500340 Human Serum Albumin EIA Kit - 2009-07-16 118.368298342541 human-serum-albumin-eia-kit Albumin (human serum) EIA Kit; HSA ELISA Kit solid plates EIAs ELISAs enzymes immunoassays kits measures measurement renal kidneys blood proteins serums osmotic pressure buffering pH hormones fatty acids transports transportation microaluminuria macroalbuminuria disease non-diabetic nephropathy cardiovascular morbidity mortality creatinine assays 118.368298342541
500910 Human Therapeutic IgG1 EIA Kit - 2011-03-01 62.544723621493 human-therapeutic-igg1-eia-kit Human IgG1 Immunometric EIA drug discovery cytotoxicity toxicology non-human primates rhesus cynomolgus monkeys pharmacokinetics serum endogenous homology immunoglobulins species EIAs enzymes immunoassays kits measures measurements humans antibody antibodies IgG4 effectors Fc receptors leukocytes mediates antibody-induced cellular cells ADCC complement-mediated complements rodent plasma 62.544723621493
500920 Human Therapeutic IgG4 EIA Kit - 2011-04-04 70.836160085581 human-therapeutic-igg4-eia-kit Human IgG4 Immunometric ELISA ELISA drug discovery cytotoxicity toxicology non-human primates rhesus cynomolgus monkeys pharmacokinetics serum endogenous homology immunoglobulins species EIAs enzymes immunoassays kits measures measurements humans antibody antibodies IgG1 effectors Fc receptors leukocytes mediates antibody-induced cellular cells ADCC complement-mediated complements rodent plasma 70.836160085581
700360 JMJD2A Inhibitor Screening Assay Kit - 2010-05-25 19.047282813814 jmjd2a-inhibitor-screening-assay-kit Jumonji Domain Containing 2A Inhibitor Screening Assay Kit kits assays measures measurements histones nucleoproteins chromatins DNA deoxynucleic acids eukaryotic nucleus nucleosomal H3 H4 H2B H2A octamers amino termini acetylation phosphorylation ubiquitination methylation replication repair transcriptional activation repression dysregulation tumors suppressor genes cancers inhibitors enzymes catalyzes epigenetic marks methyls lysines arginines residues demethylases 1 JMJC JHDM1 JHDM2 JHDM3 JARID1 UTX/UTY cupin 2-oxoglutarate 2OG iron Fe(II) oxygenases hydroxylation JMJD2A JMJD2B JMJD2C JMJD2D JMJD2E JMJD2F fluorescence-based fluorescent cells lysates formaldehydes peptides substrates oxidation/decarboxylation acetoacetanilides ammonia H3K9(Me)3 trimethylated 19.047282813814
700370 JMJD2D Inhibitor Screening Assay Kit - 2010-05-25 19.603553147282 jmjd2d-inhibitor-screening-assay-kit Jumonji Domain Containing 2D Inhibitor Screening Assay Kit kits assays measures measurements histones nucleoproteins chromatins DNA deoxynucleic acids eukaryotic nucleus nucleosomal H3 H4 H2B H2A octamers amino termini acetylation phosphorylation ubiquitination methylation FLJ10251 replication repair transcriptional activation repression dysregulation tumors suppressor genes cancers inhibitors enzymes catalyzes epigenetic marks methyls lysines arginines residues demethylases 1 JMJC cupin 2-oxoglutarate 2OG iron Fe(II) oxygenases hydroxylation JMJD2A JMJD2B JMJD2C JMJD2D JMJD2E JMJD2F fluorescence-based fluorescent cells lysates formaldehydes peptides substrates oxidation/decarboxylation acetoacetanilides ammonia H3K9(Me)3 trimethylated 19.603553147282
10008882 LDH Cytotoxicity Assay Kit - 2006-12-15 257.957353395323 ldh-cytotoxicity-assay-kit Lactate Dehydrogenase Cytotoxicity Assay Kit cells death apoptosis necrosis measuring measurement cystolic enzymes cells membranes integrity cancer cell-based assays cell based assay cba 257.957353395323
500001 Lipid Droplets Fluorescence Assay Kit - 2009-05-28 56.611253246446 lipid-droplets-fluorescence-assay-kit lipids droplets storage organelles cytoplasms eukaryotic cells mammalian adipocytes steroidogenic fatty acids metabolism membranes synthesis phospholipids cholesterols steroids PAT proteins Perilipin adipophilin tail-interacting TIP 47 intracellular homeostasis trafficking signaling immunopathological inflammation anti-inflammatory mediators leukocytes therapy assays kits measures measurements fluorescences fluorescent biogenesis Nile Red microscopy flow cytometry plates readers 56.611253246446
760700 Lipoxygenase Inhibitor Screening Assay Kit - 59.859187056037 lipoxygenase-inhibitor-screening-assay-kit LO Inhibitor Screening Assay Kit 12-LOs 15-LOs 15-lipoxygenases activity hydroperoxides assays kits inhibitors 12-lipoxygenases analysistools:lis 59.859187056037
700120 LSD1 Inhibitor Screening Assay Kit - 2008-10-16 24.063191420214 lsd1-inhibitor-screening-assay-kit Lysine-Specific Demethylase 1 lysines 4 demethylases histones residues repression transcription chromosomal DNA chromosomes inhibits inhibitors inhibition tumors suppressors activity cells cycles progression cancers fluorescent fluorescence enzymes enzymatic reactions H2O2 hydrogens peroxides peptides N-terminal tails H3 horseradish peroxidases ADHP resorufins assays 24.063191420214
600310 Lysosome/Cytotoxicity Dual Staining Kit - 2010-06-15 45.912119179162 lysosome-cytotoxicity-dual-staining-kit lysosomes membrane-bound acidic intracellular compartments cells waste products fats carbohydrates proteins macromolecules mobilize recycle organelles microorganisms animals leukocytes degradative enzymes hydrolases pH 5 cytoplasm homeostasis Tay-Sachs diseases arthritis neurodegeneratives Parkinson's brains cathepsin D genes therapeutics kits assays measures measurements 4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole NBD-PZ membranes permeable carboxylic acids luminal cultured propidium iodides death chloroquine inhibitors positive controls fluorescence fluorescent microscopy plates reader detections flow cytometry 45.912119179162
600180 Melanocortin-3 Receptor STEP Reporter Assay Kit (Luminescence) Exclusive - ✓ 2010-01-05 16.893913207725 melanocortin-3-receptor-step-reporter-assay-kit-luminescence MC3R MC-3R melanocortins petides hormones proopiomelanocortins pituitary CNS central nervous systems skin placenta tissues MCR receptors G protein-coupled GPCRs cAMP Adenosine 3',5' cyclic mononucleotides messenger signal transduction pathways melanocortin-3 hypothalmus homeostasis fat lean mass hyperphagia MC4R melanocortin-4 adiposity MC3R-knockout mice mouse murine fatty acids oxidations blood pressure hypertension obesity glucose metabolisms insulin insensitivity agonists ligands Surface transfection and expression protocols solid phase transient transfection technology originus patents USPT US6897067 US6902933 US7056741 US 6897067 6902933 7056741 DNA deoxyribonucleases adherent cells receptor-mediated endocytosis solution-phase co-transfection plasmids secretory alkalines phosphatases substrates SEAP proteins lipids signal transduction luminescence-based cell-based assays kits CBAs high-throughput screening a-MSH alpha-MSH α-MSH 16.893913207725
600190 Melanocortin-4 Receptor STEP Reporter Assay Kit (Luminescence) Exclusive - ✓ 2010-01-05 18.301739308369 melanocortin-4-receptor-step-reporter-assay-kit-luminescence MC4R MC-4R melanocortins petides hormones proopiomelanocortins pituitary CNS central nervous systems skin placenta tissues MCR receptors G protein-coupled GPCRs cAMP Adenosine 3',5' cyclic mononucleotides messenger signal transduction pathways melanocortin-3 hypothalmus homeostasis fat lean mass hyperphagia MC4R melanocortin-4 adiposity MC3R-knockout mice mouse murine fatty acids oxidations blood pressure hypertension obesity glucose metabolisms insulin insensitivity agonists ligands sexual function antagonists fever suppression inflammatory mediators in vivo Surface transfection and expression protocols solid phase transient transfection technology originus patents USPT US6897067 US6902933 US7056741 US 6897067 6902933 7056741 DNA deoxyribonucleases adherent cells receptor-mediated endocytosis solution-phase co-transfection plasmids secretory alkalines phosphatases substrates SEAP proteins lipids signal transduction luminescence-based cell-based assays kits CBAs high-throughput screening a-MSH alpha-MSH α-MSH 18.301739308369
700140 Methyltransferase Colorimetric Assay Kit - 2009-04-07 30.225331001137 methyltransferase-colorimetric-assay-kit MT Colorimetric Assay Kit assays kits measures measuring monitoring monitors MTs methylation signal transduction biosynthesis repair gene silencing chromatin regulation S-adenosylmethionine SAM-dependent methyltransferases enzymatic cofactors AdoMet donor modifications DNA Alzheimer's diseases depression Parkinson's multiple sclerosis liver failure cancers enzyme-coupled AdoHcy positive control S-adenosylhomocysteine 30.225331001137
700150 Methyltransferase Fluorometric Assay Kit - 2009-04-08 26.105699252585 methyltransferase-fluorometric-assay-kit MT Fluorometric Assay Kit assays kits measures measuring monitoring monitors MTs methylation signal transduction biosynthesis proteins repair gene silencing chromatin regulation S-adenosylmethionine SAM-dependent methyltransferases enzymes enzymatic cofactors AdoMet donor proteins modifications DNA Alzheimer's diseases depression Parkinson's multiple sclerosis liver failure cancers enzyme-coupled AdoHcy positive control S-adenosylhomocysteine 26.105699252585
705192 Monoacylglycerol Lipase Inhibitor Screening Assay Kit - 2009-10-22 102.257324388319 monoacylglycerol-lipase-inhibitor-screening-assay-kit MAGL; MGL neuroscience neurochemistry inhibitors inhibiting inhibition inhibits endocannabinoids serines hydrolases pain obesity monoglycerol 102.257324388319
10009365 MTT Cell Proliferation Assay Kit - 2007-02-15 114.533050951503 mtt-cell-proliferation-assay-kit assays kits screen measures measurements cells cellular growth factors signaling signalling molecules transcription DNA pathological cancers aging cycles progression regulatory cytokines mitogens drugs inductions inhibitors inhibits inhibitions in vitro plasma membranes formazan intracellular NAD(P)H-oxidoreductases NADPH-oxidoreductases proteins enzymes enzymatic cleavage microtiter plates tertrazolium salts mitochondrial dehydrogenases cancer cell-based assay cell based assay cba 114.533050951503
600370 Multi-Drug Resistance Assay Kit (Calcein AM) - 2011-03-31 60.297377260571 multi-drug-resistance-assay-kit-calcein-am P-glycoproteins P-gp multidrug resistance MDR1 genes associated proteins MRP ATP-binding cassette ABC transporters adenosines triphosphates luminal membranes endothelial cells blood-brain barrier BBB xenobiotic attacks tumors chemotherapy epilepsy therapeutics in vitro modulators substrates inhibitors inhibits inhibition Calcein AM cell-permeable nonfluorescent dyes fluorescence live acetomethoxy groups intracellular esterases green cytosol overexpressing assays kits measures measurements Hoechst nuclei cyclosporin A verapamil 60.297377260571
600330 Multi-Parameter Apoptosis Assay Kit - 2010-08-18 89.454780052167 multi-parameter-apoptosis-assay-kit assays kits measures measurements apoptosis cells death cycles tissues homeostasis dysregulation neurodegenerative diseases ischemic damages autoimmune disorders cancers drugs discovery signaling pathways membranes phospholipids phosphatidylserines phosphatidylethanolamines leaflets bilayers externalizations residues plasma phospholipids binding proteins fluorochrome-labeled fluorochromes annexin V fluorescence microscopy flow cytometry FC plate readers TUNEL TdT-mediated dUTP Nick-End Labeling analysis ISEL in situ end labeling DNA deoxyribonucleic acids mitochondrial transmembranes tetramethylrhodamines ethyls esters TMRE lipophilics probes laddering detection fragmentation FITC-conjugated fluoresceins 89.454780052167
700170 Myeloperoxidase Inhibitor Screening Assay Kit - 2009-04-14 99.838640883977 myeloperoxidase-inhibitor-screening-assay-kit MPO Inhibitor Screening Assay Kit heme peroxidases azurephilic granules leukocytes neutrophils monocytes tissues macrophages chlorides hydrogen peroxides H2O2 Cl- hypochlorous acids acute chronic vascular inflammatory diseases cardiac therapeutics cycles fluorescence fluorescent assays kits measures measurement crude cells lysates purified enzymes ADHP 10-acetyl-3,7-dihydroxyphenoxazine resorufin 2-[6-(4-aminophenoxy)-3-oxo-3H-xanthen-9-yl]-benzoic acid APF -OCl assays 99.838640883977
600480 NAD+/NADH Cell-Based Assay Kit New - 2012-02-29 105.680926438828 nad-nadh-cell-based-assay-kit Nicotinamide adenine dinucleotide/Nicotinamide adenine dinucleotide, reduced cells assay kits CBAs colorimetric measuring measurement Nicotinamide adenine dinucleotide/Nicotinamide adenine dinucleotide reduced cells oxidized cofactors redox oxidations reductions reactions electrons transporters cellular substrates enzymes acetyl groups proteins posttranslational respiratory functions citric acids cycles tricarboxylic TCA Kreb's ATP adenosine 5'-triphosphate oxidative phosphorylation metabolic activity biosynthesis de novo phosphoribosyltransferase NAMPT organs aging cytosolic mammalian death apoptosis signaling transcriptional metabolic disorders intracellular cultured alcohol dehydrogenases acetoaldehydes NAD kit NADP NADH NAD+ NAD-+ + 105.680926438828
600240 Orexin 1 Receptor STEP Reporter Assay Kit (Luminescence) Exclusive - ✓ 2010-03-31 10.428937998772 orexin-1-receptor-step-reporter-assay-kit-luminescence OX1R hypercretins 1 orexins 2 A orexin-2 systems regulates regulator sleep wake cycles feeding cardiovascular autonomic hypothalamic neuropeptides Orexins A Orexins B gut hormones secretions hypothalamus midbrains brainstems G protein-coupled receptors GPCRs orexin-1 OX1R orexin-2 OX2R orexin-A orexin-B sleep disorders narcolepsy humans animals rodents energy homeostasis pain stress antagonists drugs addictions withdrawals therapeutics obesity Surface transfection expression protocols solid phase transient transfection technology originus patents USPT US6897067 US6902933 US7056741 US 6897067 6902933 7056741 DNA deoxyribonucleases adherent cells receptor-mediated luminescent secretory alkaline phosphatases SEAP signal transduction cascades culture medium luminescence-based high throughput screening screens agonists 10.428937998772
600250 Orexin 2 Receptor STEP Reporter Assay Kit (Luminescence) Exclusive - ✓ 2010-03-31 9.883163122942 orexin-2-receptor-step-reporter-assay-kit-luminescence OX2R hypercretins 1 orexin 2 systems regulates regulator sleep wake cycles feeding cardiovascular autonomic hypothalamic neuropeptides Orexins A Orexins B gut hormones secretions hypothalamus midbrains brainstems G protein-coupled receptors GPCRs orexin-1 OX1R orexin-2 OX2R orexin-A orexin-B sleep disorders narcolepsy humans animals rodents energy homeostasis pain stress antagonists drugs addictions withdrawals therapeutics obesity Surface transfection and expression protocols solid phase transient transfection technology originus patents USPT US6897067 US6902933 US7056741 US 6897067 6902933 7056741 DNA deoxyribonucleases adherent cells receptor-mediated luminescent secretory alkaline phosphatases SEAP signal transduction cascades culture medium luminescence-based high throughput screening screens agonists 9.883163122942
10004380 PAF Acetylhydrolase Inhibitor Screening Assay Kit - 2004-03-29 47.752897483117 paf-acetylhydrolase-inhibitor-screening-assay-kit PAF-AH Inhibitor Screening Assay Kit; Lp-PLA2 Inhibitor Screening Assay Kit platelet-activating factors hypotension inflammations allergys PAFAH atherosclerosis heart diseases measures kits inhibitors PAFs assays paf elisa kit 47.752897483117
10004916 PBMC Fluorescent Titer Assay Kit - 2006-07-21 25.129079189686 pbmc-fluorescent-titer-assay-kit SPI-Bio spibio kits enzyme immunoassays D05003 assays fluorescence fluorescent fluorometric 25.129079189686
789201 P-Glycoprotein Drug Interaction Assay Kit - 0.937292817680 p-glycoprotein-drug-interaction-assay-kit P-gp Drug Interaction Assay Kit glycoproteins pharmacokinetics cellular detoxification ATPase ADPase assays kits interactions drugs transport photodetection spi-bio spibio D5001 0.937292817680
500290 Phagocytosis Assay Kit (IgG FITC) - 2009-04-09 143.746594904470 phagocytosis-assay-kit-igg-fitc kits assays measuring measurement ingestion killing phagocytic leukocytes defense pathogens microbe-innate immune cytoskeletal rearrangement membrane trafficking microbial mechanisms pro-inflammatory anti-inflammatory cytokines chemokines apoptosis antigen immune systems pathological Multiple Sclerosis Alzheimer's diseases atherosclerosis bacterial fungal infections in vitro fluorescently opsonizing latex beads fluorescently-labeled flow cytometry cytometric analysis quantification cell-based cell based cba 143.746594904470
10007685 PPARγ Ligand Screening Assay Kit - 2009-07-16 45.958161727774 ppar-ligand-screening-assay-kit Peroxisome Proliferator-activated Receptor γ FP-Based Ligand Screening Assay Kit - Green FP-based peroxisomes proliferator-activated receptors PPARs proliferator activated PPARgamma PPAR.gamma. PPARg PPARγ PPAR-γ PPAR-gamma gamma g γ .gamma. PPAR-.gamma. PPAR-g kits assys atherosclerosis TF diabetes drugs discovery discover endocrinology high throughput screens screening inflammations inhibitors inhibits inhibition metabolic syndromes metabolism nuclear receptors fluorescence FP-based FP based base ligands probes proteins isoforms γ1 γ2 γ-1 γ-2 1 2 adipose tissues colon immune systems retinas adipogenesis cells cellular differentiation insulin sensitization cancers fatty acids FAAH arachdionic 15-deoxy-DELTA12,14-prostaglandin 15-deoxy-DELTA12,14-PGs 15-deoxy-DELTA12,14-PGJ2 15 deoxy DELTA 12,14 PGs prostaglandins PGJ2 15-deoxy-Δ12,14-PGs 15-deoxy-Δ12,14-prostaglandins 15-deoxy-Δ12,14-PGJ2 15-deoxy-D12,14-prostaglandins 15-deoxy-D12,14-PGs 15-deoxy-D12,14-PGJ2 15-deoxy-.DELTA.12,14-prostaglandins 15-deoxy-.DELTA.12,14-PGs 15-deoxy-.DELTA.12,14-PGJ2 J2 thiazolidinediones TZD pioglitazone rosiglitazone agonists hyperglycemia hyperinsulinemia hypertriglyceridemia types 2 antidiabetics diabetes oral antagonists 45.958161727774
500581 Prostaglandin D2 FPIA Kit - Green - 2004-11-16 48.428491022099 prostaglandin-d2-fpia-kit-green PGD2 Fluorescence Polarization Immunoassay - Green PGD2 metabolites prostaglandins immunoassays HTS high-throughput kits screenings rapid measurements assays 48.428491022099
512051 Prostaglandin D2 FPIA Kit - Red - 2011-04-11 70.586690607734 prostaglandin-d2-fpia-kit-red PGD2 Fluorescence Polarization Immunoassay - Red PGD2 Fluorescence Polarization Immunoassays metabolites prostaglandins D2 immunoassays HTS high-throughput kits screenings rapid measurements assays brains glutathione-independent lipocalin-type synthases L-PGDS cerebral spinal fluids CSF physiologic sleep rats humans mast cells leukocytes cellular myeloid-type glutathione-dependent hematopoietic H-PGDS intracellular vascular 11.beta.-PGF2.alpha. 11beta-PGF2alpha 11β-PGF2α β-oxidations beta-oxidations .beta.-oxidations tetranor-PGDM metabolites eicosanoids supernatants cultures enzymes preparations biosynthesis serum proteins albumin 70.586690607734
600007 Prostaglandin D Synthase (hematopoietic-type) FP-Based Inhibitor Screening Assay Kit - Green - 2009-01-21 60.508407835258 prostaglandin-d-synthase-hematopoietic-type-fp-based-inhibitor-screening-assay-kit-green H-PGDS FP-Based Inhibitor Screening Assay Kit - Green; Prostaglandin D Synthase (hematopoietic-type) Fluorescence Polarization-Based Inhibitor Screening Assay Kit - Green assays kits measures measurements FPs fluorescent fluorescences polarizations polarization-based inhibitors inhibits inhibition prostaglandins synthases pgs H-PGDS PGD2 lipocalin-types L-PGDS allergies allergy allergic inflammatory inflammations reactions mast Th2 microglia necrotic muscles fibers apoptotic smooth HQL-79 tranilast guinea pigs lungs tissues pyrimidines amides amide-based single step fluoresceins probes Z' dynamic ranges mP units BSPTfluorescently-labeled HPGDS H-PGDS assays 60.508407835258
10006595 Prostaglandin D Synthase Inhibitor Screening Assay Kit - 2005-08-31 33.210460405156 prostaglandin-d-synthase-inhibitor-screening-assay-kit PGDS Inhibitor Screening Assay Kit prostaglandins synthases inhibitors PGDS assays hematopoietic-types lipocalin-types pro-inflammatory mediators allergic allergy allergies allergens activity inhibitors inhibition inhibits H-PGDS L-PGDS 33.210460405156
10006270 Renin Inhibitor Screening Assay Kit - 2005-05-04 55.100208717004 renin-inhibitor-screening-assay-kit Protease measurement assays aspartyl renal juxtaglomerular cells sodium depletion blood volume pressure .beta.-adrenergic stimulation angiotensinogens angiotensins I II converting ACE monomeric zinc metalloenzymes vascular endothelium messengers RAS vasoconstrictor peripheral hypertension receptors blockers fluorescence fluorescent fluorometric atherosclerosis endocrinology 55.100208717004
600260 Secreted Alkaline Phosphatase Reporter Gene Assay Kit (Luminescence) - 2010-04-27 1.745966850829 secreted-alkaline-phosphatase-reporter-gene-assay-kit-luminescence SEAP Reporter Gene kits assays measuring measurement phosphatases genes expression transfected cells culture mediums intracellular mRNA messenger ribonucleic acids proteins kinetics chromogenic substrates p-nitrophenyl para-nitrophenyl phosphates pNPP chemiluminescence chemiluminescent detections AP 1.745966850829
700270 SET7/9 Methyltransferase Inhibitor Screening Assay Kit - 2009-12-04 24.872556970425 set7-9-methyltransferase-inhibitor-screening-assay-kit methyltransferases SET Domain-containing Protein 7/9 lysines 7 KMT7 methylation signal transduction biosynthesis proteins repair genes silencing chromatins S-adenosylmethionine SAM AdoMet methyl donors Alzheimer's depression Parkinson's Diseases multiple sclerosis liver cancers substrates histones histone 3 lysine residue 4 H3K4 p53 transcription factors TAF10 mono-methylated mono-methylase DNA damage acetylation human tumorigenesis inhibitors acceptor peptides S-adenosylhomocysteine S-ribosylhomocysteine adenine nucleosidase hypoxanthine deaminase urate hydrogen peroxide H2O2 ADHP 10-acetyl-3,7-dihydroxyphenoxazine resorufin fluorescence measures measurement assays kits 24.872556970425
700350 SET8 Methyltransferase Inhibitor Screening Assay Kit - 2010-03-09 21.155178831055 set8-methyltransferase-inhibitor-screening-assay-kit SET domain-containing (lysine methyltransferase) 8; PR-Set7; SETD8 assays kits measures measurement methyltransferases MTs inhibits inhibitors inhibition methylation signal transduction biosynthesis protein repair genes silencing chromatins regulation S-adenosylmethionine (SAM)-dependent AdoMet DNA deoxyribonucleic acids Alzheimer's diseases depression Parkinson's multiple sclerosis livers cancers KMT5A lysines PR-Set 7 methylates histones H4 residues 20 H4K20 transcriptional p53 tumors suppressors tumorigenesis inhibits inhibition inhibitors peptides S-adenosylhomocysteines S-ribosylhomocysteines adenines nucleosidases hypoxanthines deaminases hydrogen peroxides H2O2 ADHP 10-acetyl-3,7-dihydroxyphenoxazines fluorescent fluorescence resorufin 21.155178831055
700280 SIRT2 Direct Fluorescent Screening Assay Kit - 2009-12-10 40.755135213724 sirt2-direct-fluorescent-screening-assay-kit Nucleosomes chromosomal deoxyribonucleases DNA histones H2A H2B H3 H4 octameric cores transcription amino termini acetylation phosphorylation methylation ε-amino lysines acetyltransferases HATs chromatins genes activation deacetylases HDACs catalyzes hydrolytic acetyls sirtuins trichostatins A-insensitive lysyl-deacetylases class III catalyzes deacetylation nicotinamides O-acetyl-ADP-ribose NAD+ human SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 cytoplasmic proteins H4 lysine-16 lysine-40 α-tubulin a-tubulin alpha-tubulin HDAC6 microtubules mitotic chromosomal hyperpolid cells tissues skeletal muscle heart oligodendroglia brain tumor suppressor gliomas Down-regulation gene chromosomal region diagnostic marker fluorescence-based inhibitors activators p53 Gln-Pro-Lys-Lys(ε-acetyl)-AMC recombinant NAD+ fluorescent fluorescence kits assays measures measurement 40.755135213724
10011566 SIRT3 Direct Fluorescent Screening Assay Kit - 2008-08-21 48.920476519337 sirt3-direct-fluorescent-screening-assay-kit SIRT 3 assays kits measures sirtuins trichostatins A-intensive lysyl-deacetylases class III HDACs human mitochondrial proteins mitochondrias localization matrix-processing peptidase translocated nucleus cells cellular stress overexpression mice mouse murine caloric restriction up-regulates expression levels white brown adipose tissue BAT cold exposure PGC-1a PGC-1alpha PGC-1.alpha. UCP1 modulates adaptive thermogenesis deacetylation activation acetyl coenzymes A synthetase 2 AceCS2 catalyzes acetate CoA ketogenesis ATP direct genetic link longevity mutations genes enhancers marker life extension cellular metabolic control whole-body metabolism chronic diseases dysfunction neuronal pathogenesis neurodegenerative cancers aging apoptosis screening fluorescence activators fluorescent fluorometric 48.920476519337
600090 Soluble Epoxide Hydrolase Cell-Based Assay Kit - 2009-05-14 12.481026045777 soluble-epoxide-hydrolase-cell-based-assay-kit sEH Cell-Based Assay Kit kits assays measuring measurement mammalian epoxides α/β-hydrolases enzymes catalyzes hydrolysis exogenous endogenous vicinal diols homodimers C-terminal N-terminal domains vasodilatory vasodilation anti-inflammatory hypertension vascular inflammation inhibitors therapeutics fluorescence-based fluorescent whole cells Epoxy Fluor 7 6-methoxy-2-naphthaldehyde AUDA 12.481026045777
10011671 Soluble Epoxide Hydrolase Inhibitor Screening Assay Kit - 2009-02-24 8.720009208103 soluble-epoxide-hydrolase-inhibitor-screening-assay-kit sEH Inhibitor Screening Assay Kit epoxides hydrolases sEHs inhibits inhibition assays kits fluorescence-based catalyzes hydrolysis exogenous endogenous vicinal diols substrates EETs epoxyeicosatrienoic acids vasodilatory vasodilation anti-inflammatory molecules therapy therapeutics hypertension vascular diseases PHOME (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester 6-methoxy-2-naphthaldehyde excitation emission wavelengths a/b-hydrolases alpha/beta-hydrolases .alpha./.beta.-hydrolases enzymes homodimers C-terminal C-terminus animals models cyanohydrins cyanide ions 8.720009208103
700330 Sphingomyelinase Inhibitor Screening Assay Kit - 2010-02-09 42.857868184608 sphingomyelinase-inhibitor-screening-assay-kit SMase assays kits measures measuring measurementsphingomyelinases SMases hydrolases enzymes sphingolipids metabolisms DNase I superfamily phosphocholines ceramides cellular cells stress pathophysiological lysosomal digestion ceramide-mediated signal transductions cytokine-induced apoptosis differentiation immune inflammatory lipoproteins aggregation vessels atherogenesis intracellular trafficking acidic neutral proliferation depressive disorders neurodegenerative disorders strokes Alzheimer's dementia diseases therapeutics cleavage conjugates free thiols 42.857868184608
10004883 sPLA2 (Type V) Inhibitor Screening Assay Kit - 2004-05-07 52.717553275453 spla2-type-v-inhibitor-screening-assay-kit Secretory Phospholipase A2 (Type V) assays measures kits inhibition inhibitors phospholipases inflammation eicosanoids colorimetric sPLA2s enzymes diheptanoyl thio-pc 52.717553275453
10012643 Steatosis Colorimetric Assay Kit Exclusive - ✓ 2008-07-01 26.926176795580 steatosis-colorimetric-assay-kit kits fatty liver lipids cells obesity assy kits measuring measurement cell-based assays cell based assay cba 26.926176795580
13228 thio-m-Toluthioamide 2362-63-2 ≥98% 2009-07-28 0E-12 thio-m-toluthioamide 3-Methylbenzenethioamide cyclic thioamides drug discovery 3-methylbenzothioamide 3-methylthiobenzamide m-methylthiobenzamide M-toluthioamide 0E-12
13229 thio-p-Toluamide 2362-62-1 ≥98% 2009-07-15 0E-12 thio-p-toluamide 4-Methylbenzenethioamide thioamide drug discovery 0E-12
10008883 WST-1 Cell Proliferation Assay Kit - 2006-09-07 75.640332189474 wst-1-cell-proliferation-assay-kit assays cells proliferation induction inhibitors inhibition inhibits growth factors signaling signalling molecules cycles regulatory factors cytokines mitogens drugs microtiter plates in vitro enzymes enzymatic cleavage tertrazolium salts formazan cellular mitochondrial dehydrogenases screen kits measures measurements cancers cell-based assay cell based assay cba 75.640332189474
10010199 WST-8 Cell Proliferation Assay Kit - 2007-09-11 75.212933875886 wst-8-cell-proliferation-assay-kit assays cells proliferation induction inhibitors inhibition inhibits growth factors signaling signalling molecules cycles regulatory factors cytokines mitogens drugs microwell plates in vitro enzymes enzymatic cleavage tertrazolium salts formazan cellular mitochondrial dehydrogenases screen kits measures measurements special:quarterly specialdiscount:50 specialstart:2007-12-01 specialend:2008-02-29 cell-based assay cell based assay cba 75.212933875886
10010200 XTT Cell Proliferation Assay Kit - 2007-09-11 54.557532260927 xtt-cell-proliferation-assay-kit assays cells proliferation induction inhibitors inhibition inhibits growth factors signaling signalling molecules cycles regulatory factors cytokines mitogens drugs microtiter plates in vitro enzymes enzymatic cleavage tertrazolium salts formazan cellular mitochondrial dehydrogenases screen kits measures measurements special:quarterly specialdiscount:50 specialstart:2007-12-01 specialend:2008-02-29 cell-based assay cell based assay cba 54.557532260927
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