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Chemical Class · Inhibitors

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Item Number Product Sizes & Pricing CAS Purity Image Exclusive Introduction Date Mojo Plain Text Name Synonyms Keywords Interest
31570 12(S)-hydroxy-16-Heptadecynoic Acid Exclusive 148019-74-3 ≥98% ✓ 0.356243093923 12-s-hydroxy-16-heptadecynoic-acid acetylene inhibitors omega-hydroxylases cytochromes P450 hydroxy fatty acids .omega.-hydroxyases w-hydroxylases inhibits 12S-hydroxy-16-heptadecynoic 0.356243093923
13610 13,14-dihydro Prostaglandin E1 19313-28-1 >98% 21.363683241252 13-14-dihydro-prostaglandin-e1 PGE0; 13,14-dihydro PGE1 PGE0 metabolites 13,14-dihydro-PGE1 prostaglandins 21.363683241252
9000281 13,14-dihydro Prostaglandin E1-d4 - ≥99% deuterated forms (d1-d4) 2004-05-06 41.217624309392 13-14-dihydro-prostaglandin-e1-d4 13,14-dh PGE1-d4; Prostaglandin E0-D4 PGE0 metabolites 13,14-dihydro-PGE1 prostaglandins GC/MS deuterium isotopes PGA2-d4 internal standards deuterated LC/MS GC-MS LC-MS mass spectrometry gas liquid chromatography spectroscopy 41.217624309392
38610 13(S)-HODE 29623-28-7 ≥98% 72.942817679558 13-s-hode hydroxy fatty acids linoleic metastasis 13-HODEs 13S-HODEs 13(S)-HODEs 13(S)HODEs 72.942817679558
338610 13(S)-HODE-d4 139408-39-2 ≥99% deuterated forms (d1-d4) 38.766077348066 13-s-hode-d4 GC/MS deuterium isotopes 13-HODE-d4 standards 13S-HODE-d4 deuterated GC-MS LC/MS LC-MS 13-HODEs 13(S)-HODEs 13S-HODEs 13(S)HODEs hydroxy fatty acids 13(S)HODE-d4 mass spectrometry 38.766077348066
81520 1400W (hydrochloride) 214358-33-5 >98% 43.403287292817 1400w-hydrochloride selective iNOS inhibitors nitric oxide synthases (2HCl) inhibits dihydrochlorides 1400-w 43.403287292817
71220 1,4-DPCA 331830-20-7 ≥98% 2007-06-22 39.309127276448 1-4-dpca 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid HIF-1.alpha. normoxic HIF-.alpha. prolyl HIF-PH inhibitors collagen fibrosis 4-hydroxylase normoxia hypoxic hypoxia-inducible factor HIF1.alpha. HIF1alpha HIFPH inhibition inhibits 39.309127276448
10010468 15-Lipoxygenase Inhibitor 1 Exclusive 928853-86-5 ≥98% ✓ 2008-10-23 34.525699815837 15-lipoxygenase-inhibitor-1 15-LO Inhibitor 1 15-LOs inhibitors inhibits inhibition oxidation inflammation thrombosis cancers lipoxygenases pyrimidobenzothiazine antioxidants 34.525699815837
37720 15(S)-HEDE 92693-04-4 ≥98% 0.180313075506 15-s-hede hydroxy fatty acids 15S-HEDEs 15-HEDEs 15(S)HEDEs 15(S)-HEDEs 0.180313075506
34720 15(S)-HETE 54845-95-3 ≥98% 36.312494080505 15-s-hete soybean 15-LOs asthma airway 15-lipoxygenases monohydroxy fatty acids 15S-HETES 15-HETES arachidonic 15(S)-HETEs 15(S)HETEs potato polyunsaturated 15HETEs 36.312494080505
334720 15(S)-HETE-d8 84807-87-4 ≥99% deuterated forms (d1-d8) 33.119594843463 15-s-hete-d8 GC/MS deuterium isotopes 15-HETE-d8 standards 15S-HETE-d8 15(S)HETE-d8 deuterated GC-MS LC/MS LC-MS 15-HETEs 15(S)-HETEs 15S-HETEs 15(S)HETEs hydroxy fatty acids mass spectrometry 15HETE 33.119594843463
10007251 15(S)-HETE Lipid Maps MS Standard 54845-95-3 ≥98% 2009-02-17 16.312885677858 15-s-hete-lipid-maps-ms-standard soybean 15-LOs asthma airway 15-lipoxygenases monohydroxy fatty acids 15S-HETES 15-HETES arachidonic 15(S)-HETEs 15(S)HETEs potato polyunsaturated MS mass spectrometry standards 15HETE 16.312885677858
36720 15(S)-HETrE 92693-02-2 ≥98% 39.902472375690 15-s-hetre DGLA 15-LOs metabolites 15-lipoxygenases 15-HETrEs hydroxy fatty acids 15(S)-HETrEs 15-HETrEs 15(S)HETrEs 39.902472375690
10080 16,16-dimethyl Prostaglandin A1 41692-24-4 ≥98% 72.236740331491 16-16-dimethyl-prostaglandin-a1 16,16-dimethyl PGA1 16,16-dimethyl-pga1 prostaglandins metabolism-resistant analogs inhibits inhibition inhibitors viral replication HSV HIV-1 herpes simplex virus human immunodeficiency type 1 72.236740331491
13076 16(R)-Iloprost - ≥98% 2008-10-10 26.308745067087 16-r-iloprost prostacyclin platelet aggregation IP receptors EP vasodilation pulmonary hypertension stereoisomers inhibits inhibitors inhibition iloprosts PGI2 26.308745067087
11039 17-AAG New 75747-14-7 ≥98% 2012-03-21 31.777777777778 17-aag KOS 953; NSC 330507; Tanespimycin; CP 127374; BMS 722782 17AAG 17 AAG inhibitors inhibits inhibition heat shock proteins Hsp90 geldanamycin cancers breasts HER2 hepatotoxicity analogs tumors prostate cells apoptosis NSC330507 NSC-330507 BMS722782 BMS-722782 CP127374 CP-127374 KOS-953 KOS953 31.777777777778
11036 17-DMAG New 467214-20-6 ≥98% 2012-03-14 20.000000000000 17-dmag NSC 707545; KOS-1022; Alvespimycin inhibitors inhibits inhibition heat shock proteins Hsp90 geldanamycin cancers inflammation renal failure tissues tumors NF-κB mice mouse diabetes KOS1022 KOS 1022 NSC-707545 NSC707545 20.000000000000
13812 17β-hydroxy Wortmannin Exclusive - ≥98% ✓ 2010-05-18 14.370954914398 17-hydroxy-wortmannin phosphoinositide 3-kinase PI3K mTOR inhibitors inhibits inhibition inhibitory cancers 17-hydroxywortmannins 17-hydroxy wortmannins hydroxywortmannins PI3-K HWT phosphatidylinositol 14.370954914398
13583 1-Aminodecylidene bis-Phosphonic Acid (sodium salt) Exclusive New - ≥95% ✓ 2012-04-02 63.575678330264 1-aminodecylidene-bis-phosphonic-acid-sodium-salt 1-Amindecane-1,1-Diphosphonic Acid 15049-93-1 sphingomyelinases ceramides apoptosis cells signaling sphingomyelin inhibitors inhibits inhibition phosphorycholine acids dexamethasone HepG2 63.575678330264
70510 1-Benzylimidazole 4238-71-5 >99% 0.923895027624 1-benzylimidazole thromboxanes synthases inhibitors inhibits imidizoles 0.923895027624
10011718 1-Deoxynojirimycin (hydrochloride) 73285-50-4 ≥95% 2008-08-25 16.572088651806 1-deoxynojirimycin-hydrochloride 1-dNM (hydrochloride); Moranoline (hydrochloride) .alpha.-glucosidases I II glycosylation glucosylation glucose pompe diseases antiviral agents HIV-1 HIV1 1dNM 1 16.572088651806
10954 1-NA-PP1 221243-82-9 ≥98% 2011-09-30 56.814033149171 1-na-pp1 1-Naphthyl-PP1; PP1 Analog inhibitors inhibits inhibition kinases mutated analogs sensitive v-Src vSrc c-Fyn cFyn CDK2 c-Abl cAbl mammalian yeast 1NMPP1 1NA-PP1 cells permeable tyrosine cell-permeable AS Src-family Src I338G v-Src-AS1 56.814033149171
13330 1-NM-PP1 221244-14-0 ≥95% 2009-07-22 61.845267034990 1-nm-pp1 PP1 Analog II inhibitors inhibits inhibition kinases mutated analogs sensitive v-Src vSrc c-Fyn cFyn CDK2 CAMKII mammalian yeast 1NMPP1 61.845267034990
13373 2',3',5'-triacetyl-5-Azacytidine 10302-78-0 ≥95% 2010-08-05 6.038779811465 2-3-5-triacetyl-5-azacytidine inhibitors inhibits inhibition DNA methyltransferases epigenetics methylation myelodysplastic syndromes cancers prodrugs 5-azacytidine 5-azacitidine azacytidine azacitidine rapid absorption o rally 6.038779811465
10011048 2,3-dihydrothieno-Thiadiazole Carboxylate - ≥98% 2008-12-14 0.224677716390 2-3-dihydrothieno-thiadiazole-carboxylate MTCC inhibitors inhibits inhibition CYP450 thiadiazoles cytochromes 0.224677716390
71200 2,4-DPD 41438-38-4 ≥98% 46.522112952732 2-4-dpd 2,4-Diethylpyridine dicarboxylate inhibits inhibition inhibitors proline-hydroxylases P564 HIF-PH HIF-1alpha HIF-1.alpha. alpha-keto glutarate .alpha.-keto a-keto cancer 46.522112952732
13222 2-Acetyl-5-tetrahydroxybutyl Imidazole 94944-70-4 ≥95% 2009-10-08 42.741312154696 2-acetyl-5-tetrahydroxybutyl-imidazole THI; 2-ATHBI; 2-Acetyl-4-tetrahydroxybutyl Imidazole sphingosines-1-phosphates S1P lyases S1PL inhibitors lymphatic tissues lymphocytes egress thymus lymphoid organs lymphopenia immunosuppression THI 42.741312154696
10007121 2-cyano-Pyrimidine 14080-23-0 >98% 2006-06-19 1.070767955801 2-cyano-pyrimidine Bridge organics inhibits inhibition inhibitors cathepsin K osteoporosis bone resorption osteoclasts lysosomes cysteine proteases 1.070767955801
10010494 2-PCPA (hydrochloride) - ≥98% 2008-05-09 0.466140489344 2-pcpa-hydrochloride trans-2-Phenylcyclopropylamine; Tranylcypromine 2 PCPA 2PCPA LSD1 histones chromatin nucleosomes post-translational modifications posttranslational methylation demethylation inhibitors inhibits inhibition MAO A B I MAOA MAOB MAOI MAO-A MAO-B MAO-I depression anxiety parkinsons disease epigenetics monoamine oxidases lysine-specific demethylase 0.466140489344
10727 3,5-dimethyl PIT-1 701947-53-7 ≥98% 2011-05-25 12.344984039287 3-5-dimethyl-pit-1 PIP3 PtdIns-(3,4,5)-P3 PH domain cancers inhibitors Akts PDK1 PTENs proteins binding inhibits inhibited inhibition DM-PIT-1 12.344984039287
10397 3-amino Benzamide 3544-24-9 ≥98% 2011-10-07 2.107037223058 3-amino-benzamide 3-(Aminocarbonyl) Aniline; 3-Carboxamidoaniline poly(ADP-ribose) polymerases PARPs DNA repairs DNA strands breaks apoptosis inflammation atherosclerosis neruogenesis cancers angiogenesis signaling cellular responses inhibits inhibitor inhibition telomere shortening shortens stimulates mediated mediates PARP-mediated 2.107037223058
13574 3-bromo-5-phenyl Salicylic Acid Exclusive 4906-68-7 ≥95% ✓ 2010-08-10 16.991309392265 3-bromo-5-phenyl-salicylic-acid NSC 109116 Aldo-keto reductases AKR, oxidoreductases hydroxysteroid dehydrogenases HSDs 20α-HSD progesterones cancers steroids brain functions AKR1C1 AKR1C2 AKR1C3 AKR1C4 endothelial cells 16.991309392265
9000786 3-Deaza-2'-deoxyadenosine 78582-17-9 ≥98% 2011-06-15 60.266809392265 3-deaza-2-deoxyadenosine c3dA inhibitors genes regulation immunology lymphocytes cytolysis nucleosides adenine nitrogen DNA 60.266809392265
9000785 3-Deazaadenosine 6736-58-9 ≥98% 2011-06-14 1.138121546961 3-deazaadenosine c3Ado; deaza-Ado; DZA S-adenosylhomocysteine hydrolases homocysteine S-adenosylmethionine methyltransferases inhibitors SAH anti-inflammatory NF-κB NF κB NF kB anti-viral anti-bacterial inflammation infectious diseases leukocytes chemotaxis lymphocyte-mediated cytolysis phagocytosis degranulation signaling 3-DZA ado inhibits inhibition SAM 1.138121546961
13828 3-Deazaneplanocin A 102052-95-9 ≥98% 2011-02-18 231.492454617205 3-deazaneplanocin-a DZNep; NSC 617989 EZH2 KMT6 methyltransferases histones cancer epigenetics panobinostat 3deazaneplanocin 3-cyclopentene-1,2-diol deriv Adenosine Adenocard 231.492454617205
10011040 4,5-diphenyl-1,2,3-Thiadiazole 5393-99-7 ≥98% 2008-11-15 0.674033149171 4-5-diphenyl-1-2-3-thiadiazole NSC 2505 thiadiazoles inhibitors inhibits inhibition CYP450 4,5-diphenylthiazole enzymes cytochrome 0.674033149171
10495 4-iodo-SAHA 1219807-87-0 ≥98% 2011-01-10 21.372640883977 4-iodo-saha anti-cancers HDACs inhibitors anti-proliferation 4-Hydroxy-5-iodo-3-nitrophenyl)acetyl 4-Hydroxy-3-iodo-5-nitrophenyl)acetyl 5-Iodo-4-hydroxy-3-nitrophenacetyl 5 Iodo 4 hydroxy 3 nitrophenacetyl Nitrohydroxyiodophenylacetate Hydroxyiodonitrophenylacetate Hapten NIP Acetyl Acetyl Hapten NIP NIP Acetyl Hapten NIP-Hapten NIP Hapten 21.372640883977
13140 4-(n-nonyl) Benzeneboronic Acid 256383-45-6 ≥98% 2009-11-04 6.628153775322 4-n-nonyl-benzeneboronic-acid fatty acids amide hydrolase FAAH endocannabinoids arachidonoyl ethanolamides AEA inhibitors inhibit monoacylglycerol lipase MAGL 2-arachidonoyl glycerol 2-AG 2AG 2 AG inhibition cannabinoids cbs synthetic 6.628153775322
10011049 4-phenyl-5-methyl-1,2,3-Thiadiazole 64273-28-5 ≥98% 2009-03-14 0.337016574585 4-phenyl-5-methyl-1-2-3-thiadiazole NSC 358739 cytochrome P450 CYP450 CYP2B4 CYP2E1 CYP1A2 inhibitors inhibits inhibition thiadiazoles fungicide herbicide plant growth regulator 0.337016574585
90200 5,8,11-Eicosatriynoic Acid 13488-22-7 ≥99% 17.439867403315 5-8-11-eicosatriynoic-acid 5,8,11-ETI acetylene inhibitors lipoxygenase cyclooxygenase fatty acids 17.439867403315
70265 5-Aminosalicylic Acid 89-57-6 >99% 2.047142857143 5-aminosalicylic-acid 5-ASA aspirin 5asa acids COX-1 COX-2 cox1 cox2 cyclooxygenases prostaglandin synthases synthase-1 synthase-2 pghs1 pghs2 pghs-1 pghs-2 ltb4 leukotriene 2.047142857143
11164 5-Azacytidine New 320-67-2 ≥95% 2012-02-16 7.670126563710 5-azacytidine Antibiotic U 18496; Mylosar; NSC 102816; U 18496; NSC 103-627; 5-AzaC; Ladakamycin; WR 183027 52934-49-3 292869-98-8 ledakamycin azacitidine 5-azacitidine 5 azacitidine 5 azacytidine 5-AZCR 5-AZC 5-AC methyltransferases histones cancers epigenetics cytidine inhibitors DNA RNA inhibits inhibition diseases cells 7.670126563710
13379 5-bromo-3-phenyl Salicylic Acid 99514-99-5 ≥95% 2010-08-10 17.205121546960 5-bromo-3-phenyl-salicylic-acid Aldo-keto reductases AKR oxidoreductases hydroxysteroid dehydrogenases HSD 20α-HSD progesterone cancers steroids brain functions AKR1C1 AKR1C2 AKR1C3 AKR1C4 endothelial cells 17.205121546960
11635 5-Fluorocytosine New 2022-85-7 ≥95% 2012-04-16 56.784530386740 5-fluorocytosine Ancobon; Ro 2-9915; 5-FC; Ancotil; NSC 103805 flucytosin fluocytosine fluorocytosine alcobon ancotyl prodrugs 5-fluorouracil cytotoxic inhibitors inhibits inhibition Candida species Cryptococcus neoformans viral infection cancers cytosine deaminase 5 fluorocytosine fluorine drugs DNA proteins sybthesis cells CT26 Tu-2449 tumors flucytosine 56.784530386740
34215 (±)5-HETE lactone 73279-37-5 ≥98% 8.631475138122 -5-hete-lactone racemic hydroxy acids lactones autoxidation (+/-)5-HETEs fatty (+/-)-HETEs (+/-)HETEs inhibitors inhibits 5-LOs 5-lipoxygenases 8.631475138122
10010375 5-Iodotubercidin 24386-93-4 ≥95% 2008-01-24 53.323775322284 5-iodotubercidin Itu; NSC 113939 adensosine glycogen hepatocytes phosphorylase .alpha. glycogen synthase .alpha. kinases protein kinase A casein kinases II casein kinases I protein kinase C phosphorylase kinases EFK2 MAPK1 cell proliferations fatty acid oxidations lipogenesis acetyl-CoA carboxylase 53.323775322284
10009598 6,7-dihydroxy Bergamottin 145414-76-2 ≥98% 2007-07-24 4.857292817679 6-7-dihydroxy-bergamottin 6,7-DHB cytochrome P450 CYP3a4 inhibitors inhibits inhibition grapefruit juice testosterone ingestion drugs metabolized metabolite metabolism stereochemistry endocrinology 4.857292817679
81040 6,7-Dimethyltetrahydropterin (hydrochloride) 167423-51-0 ≥99% 8.000000000000 6-7-dimethyltetrahydropterin-hydrochloride GTP cyclohydrolase inhibitors inhibits 8.000000000000
10009315 6-Aminonicotinamide 329-89-5 ≥98% 2008-11-21 1.353038674033 6-aminonicotinamide 6-AN; NSC 21206; SR 4388 inhibitors inhibits inhibition 6-phosphoguconate dehydrogenase cancers ATPs oxidative injury neurodegeneration cardiovascular 1.353038674033
70620 6-methoxy Naphthalene Acetic Acid 23981-47-7 >99% 2.614227542459 6-methoxy-naphthalene-acetic-acid 6-MNA cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits 2.614227542459
81882 7,8-dihydro-L-Biopterin 6779-87-9 >97% 26.565745856353 7-8-dihydro-l-biopterin Dihydrobiopterin; BH2 GTP cyclohydrolase inhibitors tetrahydrobiopterin 26.565745856353
10007900 8,11,14-Eicosatriynoic Acid Exclusive 34262-64-1 ≥98% ✓ 2007-03-12 16.707301002659 8-11-14-eicosatriynoic-acid 8,11,14-ETI Cyclooxygenases COX 12-LO 15-LO 5-LO Inhibitor Fatty acids Acetylenic Lipoxygenases SRS-A FA 16.707301002659
90100 8,11-Eicosadiynoic Acid 82073-91-4 ≥95% 3.418139963167 8-11-eicosadiynoic-acid EDYA acetylene inhibitors delta-5-desaturase cyclooxygenases .DELTA.-5-desaturase D-5-desaturase inhibits fatty acids D5-desaturase 3.418139963167
89300 8-hydroxy Guanosine - ≥98% 10.225303867403 8-hydroxy-guanosine oxidative injury RNA stress damage 7,8-dihydro-8-oxo-guanosine markers inhibitors growth 3868-31-3 10.225303867403
10012588 A-803467 944261-79-4 ≥98% 2009-02-14 0.165745856354 a-803467 Nav1.8 sodium channels neuropathic pain inflammatory blockers inhibitors inhibits inhibition TTX-resistance TTX-R 0.165745856354
10012708 A-922500 959122-11-3 ≥95% 2010-12-21 29.572946593001 a-922500 (1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid triglyceride obesity insulin resistance inhibitors metabolic syndrome diacyl glycerolacyltransferase DGAT-1 DGAT1 DGAT 1inhibits inhibition A-922500 A922500 mice murine diet induced obesity DIO diet-induced Compounds, Biphenyl Biphenyl Compounds 29.572946593001
13649 Abacavir (hydrochloride) 136777-48-5 ≥98% 2010-08-17 48.035276243094 abacavir-hydrochloride carbovirs triphosphates inhibitors inhibits inhibition HIV reverses transcriptases AIDS sulphates HCl 1592 U89 1592-U89 human bones marrow progenition cells blood-brain barrier 2',3'-Dideoxy-3'-thiacytidine 2',3' Dideoxy 3' thiacytidine Lamivudine, (2S-cis)-Isomer 2',3'-Dideoxynucleosides 2',3' Dideoxynucleosides Dideoxyribonucleosides Dideoxynucleosides Lamivudine GR-109714X GR109714X BCH-189 BCH 189 EpivirBCH189 ddNus 3TC ziagen 188062-50-2 1592U89 48.035276243094
13653 ABT-869 796967-16-3 ≥98% 2010-12-09 38.810202578269 abt-869 Linifanib inhibitors RTK tyrosine kinases VEGF PDGF cancers KDR Flt1 Flt3 Flt4 CSF-1R KIT acute myeloid leukemia antiproliferative anti-proliferative ABT 869 ABT869 Indazoles 38.810202578269
11570 AG-014699 New 459868-92-9 ≥98% 2012-03-15 21.205033763044 ag-014699 PF-01367338; Rucaparib phosphate AG-014447 AG 014447 AG-014699 AG-14699 014699 14699 PF 01367338 Poly(ADP-ribose) polymerases PARPs DNA DAN repair deoxyribonucleic acids damages lethal cells mutations BRCA1 BRCA2 therapeutics cancers cell-permeable inhibits inhibitors inhibition PARP-1 chemotherapy activity homologous recombination pathways tumors growths mice mouse epigenetics epigenetically silenced UACC3199 xenograft efficacy temozolomide medulloblastomas 21.205033763044
13297 AG-126 118409-62-4 ≥95% 2009-07-14 5.198800315706 ag-126 Tyrphostin AG-126 tyrphostins proteins tyrosine inhibitors inhibits inhibition cells growth epidermal growth factors receptors kinase GFRK EGFs EGFRK PDGF PDGFRK platelet-derived platelet derived phosphorylation ERK1 p44 ERK2 p42 TNF-α TNFα TNF α NF-κB NFκB NF κB COX-2 COX2 iNOS inflammation 5.198800315706
10010592 AG-1296 146535-11-7 >98% 2008-05-09 7.666917127072 ag-1296 Tyrphostin AG-1296 tyrphostins AG1296 PDGFR PTK SCF inhibitors inhibits inhibition receptors kinases proteins platelet-derived platelet derived growth factors in vitro cancer glioma athrosclerosis restenosis AG1296 AG 1296 7.666917127072
10010244 AG-1478 153436-53-4 ≥98% 2008-04-22 10.902276243094 ag-1478 NSC 693255; Tyrphostin AG-1478 NSC 693255 EGFR PTK inhibitors inhibits inhibition kinases receptors cancers antitumor leioyoma myometrium 175178-82-2 AG1478 AG 1478 t4182 10010244-t4182 10.902276243094
10010248 AG-17 10537-47-0 ≥98% 2007-09-18 1.714819379516 ag-17 NSC 242557; Tyrphostin 9; Malonoben; Tyrphostin AG-17; SF 6847; GCP 5126; RG-50872 proteins tyrosine kinases PTK inhibitors inhibits antiproliferative epidermal growth factor EGF receptors proliferations carcinomas AG17 AG 17 SF6847 SF-6847 GCP-5126 GCP5126 1.714819379516
10010300 AG-18 118409-57-7 >98% 2007-12-20 1.702732681683 ag-18 RG-50810; TX 825; Tyrphostin AG-18; Tyrphostin 23; RG-50858 proteins tyrosines kinases PTKs inhibitors inhibition inhibits antiproliferative epidermal growth factors EGF receptors proliferations carcinoma cancers epidermoid cell lines A431 AG18 AG 18 A23 A-23 A23 RG50810 RG 50810 RG50858 RG 50858 TX-825 TX825 1.702732681683
10010315 AG-183 122520-90-5 ≥98% 2007-09-07 1.496800184161 ag-183 Tyrphostin 51 proteins tyrosine kinases PTKs inhibitors inhibition inhibits inhibition antiproliferative epidermal growth factors EGFs receptors proliferation carcinomas cancers epidermoid AG183 AG 183 1.496800184161
10010314 AG-213 122520-86-9 ≥97% 2008-02-05 2.466539427423 ag-213 Tyrphostin AG-213; Tyrphostin 47 protein tyrosine kinases PTKs inhibitors inhibits inhibition antiproliferative epidermal growth factors EGFs receptors proliferation carcinomas A431 epidermal AG213 Ag 213 118409-60-2 2.466539427423
10010568 AG-370 134036-53-6 >95% (cis/trans mixture) 2009-01-09 1.229594843462 ag-370 NSC 651712 PTK inhibitor tyrphostin tyrosine PDGF receptor kinase EGF receptor antiproliferative 1.229594843462
10010311 AG-490 133550-30-8 ≥98% 2007-12-01 7.543591160220 ag-490 PTK tyrosine kinase inhibitors inhibition inhibits antiproliferatives tyrphostins leukemia Jak-2 Jak2 AG490 7.543591160220
10010242 AG-494 133550-35-3 ≥98% 2008-02-08 1.671809392265 ag-494 protein tyrosine kinases PTKs inhibitors inhibits inhibition antiproliferative RG-13022 epidermal growth factors EGFs receptrors cancers proliferation 1.671809392265
10010312 AG-82 118409-58-8 ≥95% 2008-03-14 4.373550644567 ag-82 Tyrphostin AG-82; NSC 676484; RG-50875; Tyrphostin 25 proteins tyrosines kinases PTKs inhibitors inhibits inhibition antiproliferative epidermal growth factors EGFs receptors proliferation carcinomas blockers A431 AG82 AG 82 RG-50875 RG50875 A25 A-25 4.373550644567
10010243 AG-825 149092-50-2 ≥98% 2008-01-24 2.012059984214 ag-825 Tyrphostin AG-825 Her-2 Her-2/neu erbB tyrosine kinases EGF EGFR cancers anti-cancer prostate breast signal transduction inhibitors inhibition inhibits AG825 AG 825 2.012059984214
10793 AG-879 148741-30-4 ≥95% 2011-05-06 2.752812154696 ag-879 Tyrphostin AG-879 PTKs inhibitors tyrphostins tyrosine kinases antiproliferative NGF TrkA ErbB2 FLK-1 AG879 AG 879 inhibited inhibition 2.752812154696
10010313 AG-99 122520-85-8 ≥98% 2007-12-19 1.334737569060 ag-99 Tyrphostin 46 protein tyrosine kinase PTKs inhibitor inhibits inhibition antiproliferatives epidermal growth factors EGFs receptors proliferation carcinoma cancers blochers EGF-dependent A431 cell lines AG99 AG 99 1.334737569060
13145 AGK2 304896-28-4 ≥98% 2009-10-22 11.670718232044 agk2 sirtuins SIRT2 histones deacetylase HDAC cells cycle progression tumorigenesis cancers SIRT1 SIRT3 dopamine neurons α-synuclein Parkinson's diseases neurodegeneration 11.670718232044
13642 Alendronate (sodium hydrate) 121268-17-5 ≥95% 2010-08-02 43.491362799263 alendronate-sodium-hydrate MK-217; G-704650; Fosamax; Adronat Bisphosphonates bones resorption osteoclasts osteoblasts osteoporosis bone mineral density fractures metabolic diseases vertebral fractures increase decreases 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate 4 Amino 1 Hydroxybutylidene 1,1 Biphosphonate Bisphosphonate Aminohydroxybutane Alendronate Monosodium Trihydrate Aminohydroxybutane Bisphosphonate Sodium Alendronate Alendronate Sodium Alendronate Fosamax MK-217 MK 217 MK217 43.491362799263
13648 Alfuzosin (hydrochloride) 81403-68-1 ≥98% 2010-07-19 0E-12 alfuzosin-hydrochloride Uroxatral; SL 77499-10 α1-adrenergic receptors antagonists lower urinary tract symptoms benign prostatic hyperplasia BPH adrenoceptors α1A α1B α1D contractions smooth muscles antihypertensives vasodilators urinary flow 133880-44-1 Urion Alfoten SL 77-499-10 anti-hypertensives alpha 1 .alpha.1 Xatral Quinazolines 0E-12
10012597 Allopurinol 315-30-0 ≥98% 2009-12-07 21.509060773481 allopurinol xanthine oxidoreductase oxidation hypoxanthine uric acids dehydrogenases oxidases superoxides inhibitors inhibition inhibits gout hyperuricemia oxypuriol 21.509060773481
11306 Alternariol New 641-38-3 ≥98% 2012-01-31 25.710437424249 alternariol AOH; NSC 638263 11003-13-7 fungus molds mycotoxins toxins metabolites Alternaria CYP450 cytochromes P450 1A1 cytotoxin fetotoxin teratogenic mutagenic genotoxin apoptosis hepatoma cells 641-38-3 AC1NSEOY A1312 ZINC00402623 NSC-638263 NSC638263 CCRIS6734 CCRIS-6734 NCGC00180653-01 LS61189 LS-61189 LS 61189 NP001789 NP-001789 NP 001789 C16838 C-16838 C 16838 5-18-04-00516 BRD-K62196712-001-01-3 25.710437424249
10010332 AMP-Deoxynojirimycin Exclusive 216758-20-2 ≥95% ✓ 2008-11-21 7.960876023905 amp-deoxynojirimycin Adamantane-pentyl-dNM; N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin; AMP-dNM inhibitors inhibits inhibition ceramides lipids glycolipids glucosylceramide synthase glucosylceramidase β-glucosidase 2 glucosidase sphingomyelin deoxynorjirimycin nojirimycin inflammation antiinflammatory anit-inflammatory hapten colitis insulin sensitivity resistance SREBPs sterol genes expression cholesterol HepG2 cells 7.960876023905
13144 Anacardic Acid 16611-84-0 ≥98% 2010-02-12 5.862559731964 anacardic-acid 6-pentadecyl Salicylic Acid HAT histones acetylation P300 pCAF transcription NF-κB IκBα p65 6-pentadecyl salicyclic acids NSC 623096 cyclogallipharic 229596 333857 5.862559731964
11001 Anatabine 2743-90-0 ≥95% 2011-11-10 0.160220994475 anatabine alkaloids solanaceae tobacco Alzheimer’s diseases amyloid beta Aβ β-secretase BACE-1 NF-κB inflammation urine nicotine transcription proteins SHSY-5Y cells 0.160220994475
11308 Anisomycin New 22862-76-6 ≥98% 2012-02-13 29.177773401653 anisomycin NSC 76712; Flagecidin; Wuningmeisu C 2322-08-9 11023-48-6 antibiotics inhibitors proteins DNA stress-activated kinases MAP caspase-8 cancers immunology immunosuppressant pyrrolidines Streptomyces griseolus synthesis signal transduction pathways T cells skin mice anoikis epithelial apoptosis ECM distal tumors prostate metastasis NSC76712 NSC-76712 29.177773401653
10575 Apicidin New 183506-66-3 ≥98% 2012-01-27 21.579683293496 apicidin OSI 2040 funfal toxins malaria HDAC HAT histones deacetylase transcriptions epigenetics anticancer anti-cancer antiproliferation antiparasitic anti-proliferation anti-parasitic apicomplexan parasites HDAC3 HDAC-3 NcoR HDAC3/NcoR class I HDACs p21 WAF1/Cip1 WAF1 Cip1 gelsolin cells cycle morphology inhibits inhibitors inhibitions chromatin cancers deacetylase modification 21.579683293496
10010275 Apigenin 520-36-5 ≥98% 2008-02-18 194.735082872928 apigenin Versulin; NSC 83244; Flavone; Chamomile flavonoids flavones CK2 inhibitors inhibits inhibition inflammatory response anti-inflammatory anti-oxidant NO PGE2 iNOS COX-2 I.kappa.B.alpha. NF-.kappa.-B renal cortex 194.735082872928
90050 Arachidonoyl Ethanolamide 94421-68-8 ≥98% 44.704675456451 arachidonoyl-ethanolamide Anandamide; AEA cannabinoids neurotransmitter ligands lipids CB1 CB2 receptors AEA fatty acids neuroscience neurochemistry ethanolamines ethanolamides endocrinology 44.704675456451
10007270 Arachidonoyl Ethanolamide Lipid Maps MS Standard 94421-68-8 ≥98% 2009-02-18 7.096138971526 arachidonoyl-ethanolamide-lipid-maps-ms-standard AEA; Anandamide cannabinoids neurotransmitter ligands lipids CB1 CB2 receptors AEA fatty acids neuroscience neurochemistry ethanolamines ethanolamides endocrinology MS mass spectrometry standards 7.096138971526
13321 ARP 100 704888-90-4 ≥98% 2009-10-07 2.175690607734 arp-100 MMP-2 Inhibitor III; CAY10609 matrix metalloproteinases MMP-2 MMP2 MMP 2 ECM cancers cells migration inhibitors gelatinase A MMPs proteases HT1080 tumors invasive 2.175690607734
13622 AS-041164 Exclusive 1146702-72-8 ≥98% ✓ 2010-01-25 14.118729281768 as-041164 phosphoinositides 3-kinases PI3K cells growth migration metabolism inhibitors inhibits PI3Kα PI3Kβ PI3Kγ PI3Kδ chemotaxis inflammation neutrophils AS041164 AS-041164 RANTES 14.118729281768
13250 (−)-AS 115 926657-43-4 ≥98% 2009-05-18 2.622762430939 -as-115 KIAA1363 MAGE monoacylglycerol LPA LPC lysophosphatidylcholine lysophosphatidic acid lipids signaling cancers signalling 2.622762430939
10009650 (+)-AS 115 - ≥98% 2009-05-19 0.874254143646 -as-115 KIAA1363 MAGE monoacylglycerol LPA LPC lysophosphatidylcholine lysophosphatidic acid lipids signaling cancer 0.874254143646
10009052 AS-252424 900515-16-4 ≥95% 2007-01-30 25.573676284018 as-252424 phosphoinositides 3-kinases PI-3 PI3-K Phosphatidylinositol inhibitors PI3K .gamma. inhibition inhibitory PtdIns AS252424 25.573676284018
10010175 AS-604850 Exclusive 648449-76-7 ≥98% ✓ 2007-07-23 11.889067253257 as-604850 phosphoinositides 3-kinases PI3-kinase PI3-K phosphatidylinositol inflammatory drugs inflammation arthritis rheumatoid peritonitis neutrophils recruitment PtdIns inhibitors inhibits inhibiton PI3K 11.889067253257
10007707 AS-605240 648450-29-7 >98% 2007-06-13 15.216846364194 as-605240 phosphoinositide 3-kinases PI3-kinase PI3-K PI3K phosphoinositide phosphatidylinositols inibitors inflammation arthritis rheumatoid peritonitis neutrophils recruitment as605240 15.216846364194
9000980 AS-605240 (potassium salt) Exclusive - ≥98% ✓ 2011-03-25 14.786789441375 as-605240-potassium-salt phosphoinositides 3-kinases PI3-kinases PI3-K PI3K phosphatidylinositols inhibitors inflammation arthritis rheumatoid peritonitis neutrophils recruitment as605240 as 605240 PIs salts solubility soluble 14.786789441375
11226 AS-703026 New 1236699-92-5 ≥98% 2012-03-08 27.541067090939 as-703026 MSC1936369B AS 703026 AS703026 1204531-26-9 MEKs MEK1/2 MEK-1/2 MEK1 MEK2 ERKs Ras Raf inhibitors inhibits inhibitions cancers multiple myeloma EGFR signals transductions kinases cells biology 27.541067090939
70260 Aspirin 50-78-2 >99% 2.845864352549 aspirin Acetylsalicylic Acid atherosclerosis cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits 2.845864352549
13160 AT-56 Exclusive 162640-98-4 ≥95% ✓ 2010-06-22 6.983799877225 at-56 Prostaglandins D synthases L-PGDS PGD2 lipocalin-type inflammation inhibition inhibitors inhibits PGs eosinophils LPGDs bronchoalveolar lavage fluid Lysosomal Proton Translocating ATPases Vacuolar Proton-Translocating ATPases Vacuolar Membrane H(+)-ATPase Proteins Membrane-Associated Membrane-Associated Proteins Membrane Associated Proteins Tacrolimus Binding Proteins Proteins Rapamycin-Binding Proteins Integral Membrane Membrane Proteins Integral Binding Proteins Rapamycin Rapamycin-Binding Proteins Rapamycin Binding Proteins Protein Integral Membrane Integral Membrane Proteins Vacuolar F(1)F(0) ATPasesLysosomal F(1)F(0) ATPase Integral Membrane Protein Vacuolar F(1)F(0) ATPase Proteins Cell Membrane Protein FK-506-Binding Proteins Cell Surface Protein FK506-Binding FK-506-Binding ProteinFK506 Binding Proteins FK 506 Binding Protein Cell Membrane Proteins FK506-Binding ProteinFK506 Binding Protein Cell Surface Proteins H+-ATPase, Vacuolar Vacuolar H+-ATPase Vacuolar H+ ATPase Proteins Membrane Proteins Vacuolar ATPase Rotamase FKBP V Type ATPase FKBP Rotamase Membrane FKBP 6.983799877225
10493 Atorvastatin 134523-00-5 ≥98% 2010-08-10 7.486740331491 atorvastatin Lipitor®; Cardyl lipitors statins inhibitors inhibits inhibition HMG-CoA HMGCoA HMG CoA reductase mevalonate pathways cholesterol cardiovascular hypercholesterolemia dyslipidemias low density lipoproteins LDLs cytochromes P450 CYP3A4 myocardial infarction strokes low-density 7.486740331491
13375 Atrazine 1912-24-9 ≥98% 2010-02-11 0E-12 atrazine herbicides plants cancers reproductive systems reproduction homones endocrines frogs genes expressions humans animals Gesamprim Atrazine 0E-12
10011336 Avenanthramide-C methyl ester Exclusive 955382-52-2 ≥95% ✓ 2009-06-18 63.084175874769 avenanthramide-c-methyl-ester Inhibitors NF-κB IL-6 IL-8 MCP-1 IκB inhibits inhibition Interleukins 63.084175874769
13823 AX 048 Exclusive 873079-69-7 ≥98% ✓ 2010-09-15 7.192651933702 ax-048 Inflammation antihyperalgesia cPLA2 phospholipases inhibitors inhibition inhibits AX048 AX-048 signaling signalling group IVA PLA2 cannabinoids cbs synthetic Acids Octanoic Octanoic Acids 7.192651933702
11491 AZD 7762 New 860352-01-8 ≥98% 2012-04-11 51.111111111111 azd-7762 1019773-80-8 DNA damage repair checkpoints cells cycles kinases Chk1 Chk2 S phases G2 tumors cancers inhibitors inhibits inhibition AZD-7762 AZD7762 ATP Chk-1 Chk-2 Chk 1 Chk 2 51.111111111111
11038 Bafilomycin A1 New 88899-55-2 ≥98% 2012-03-14 24.993150684932 bafilomycin-a1 NSC 381866 NSC-381866 NSC381866 inhibitors inhibits inhibition autophagy autophagosomes protons pump vacuolar ATPase V-ATPase mammals plants fungus cells 24.993150684932
10010266 BAY-11-7082 19542-67-7 ≥98% 2008-07-25 33.128187845303 bay-11-7082 inhibitors inhibits inhibition NFkB NF-.kappa.B NF-kB NF-kappaB TNF.alpha. TNFa TNFalpha I.kappa.B-.alpha. IkB-a IkappaB-alpha inflammation cytokine cell adhesion ICAM-1 ICAM1 VCAM-1 VCAM1 E-selection Eselection Bay 11-7082 BAY-117821 Bay117082 BAY 117821 33.128187845303
10009644 BAY-43-9006 284461-73-0 ≥98% 2011-09-13 25.839792817680 bay-43-9006 Sorafenib; Nexovar® inhibitors raf-1 b-raf receptors tyrosine kinases VEGF VEGFR PDGF PDGFR cancers angiogenesis apoptosis tumors cells cellular proliferation Flt-3 c-KIT carcinoma growth factor tosylate 25.839792817680
10011135 BAY-60-7550 439083-90-6 ≥95% 2009-03-13 55.561077348066 bay-60-7550 inhibitors inhibits inhibition cyclic nucleotides cGMP cAMP cells signalling signaling PDE2 memory memories phosphodiesterase 55.561077348066
10170 BEC 63107-40-4 >98% 2006-02-15 23.296045825530 bec inhibitors L-arginases I II substrates nitric oxides synthases iNOS cells catalyzes oxidations citrullines N.omega.-hydroxy-L-arginine NOHA intermediates hydrolysis urea L-ornithine recombinant rat livers human inhibits murine NO-dependent relaxation penile corpus cavernosum smooth muscle in vitro 23.296045825530
70520 Bestatin (hydrochloride) 65391-42-6 >99% 131.192044198895 bestatin-hydrochloride LTA4 hydrolase inhibitors leukotrienes LTB4 131.192044198895
10010517 BIBB 515 156635-05-1 ≥98% 2008-06-16 0.824088397790 bibb-515 inhibitor inhibits inhibition BIBB515 OSC LDL 2,3-oxidosqualene cyclase cholesterol BIBB-515 0.824088397790
11022 BIBF 1120 928326-83-4 ≥95% 2011-11-10 6.088397790055 bibf-1120 Vargatef™ receptors tyrosine kinases inhibitors vascular endothelial growth factor VEGFR platelet-derived growth PDGFR fibroblasts FGFR angiogenesis cancers pulmonary fibrosis diseases 6.088397790055
13123 BIO 667463-62-9 ≥98% 2009-06-09 39.414977398292 bio GSK 3 IX; MLS 2052 GSK-3α GSK-3β inhibitors Cdk cells cycle wnt ESCs differentiation embryonic stem GSK-3a/b GSK3a/b 39.414977398292
10960 Bisdemethoxycurcumin 24939-16-0 ≥98% 2011-08-09 23.565733578882 bisdemethoxycurcumin BDMC curcumin activators macrophages phagocytosis 1α,25-dihydroxyvitamin D, amyloid-β Alzheimer’s diseases cancers transcription genes expression p300 Wnt/β-catenin iNOS inflammation bisdemethoxy curcumin 33171-05-0 23.565733578882
13298 Bisindolylmaleimide I 133052-90-1 ≥95% 2009-08-28 25.781082722961 bisindolylmaleimide-i Gö 6850; GF 109203X; BIM 634199-82-9 682340-45-0 inhibitors inhibits inhibitions PCK GSK-3 GSK3 staurosporine 5-HT3 receptors 5HT3 Go 6850 25.781082722961
11020 Bisindolylmaleimide II New 137592-45-1 ≥97% (isomer mixture) 2012-03-13 33.836712196878 bisindolylmaleimide-ii PKC staurosporines inhibitors inhibits inhibition PDK1 PKA kinases C PKCα signaling insulin ligands binding protein kinase C 33.836712196878
13299 Bisindolylmaleimide IV 119139-23-0 ≥98% 2009-07-29 12.639200145022 bisindolylmaleimide-iv Arcyriarubin A PKC PKA staurosporine inhibitors 634199-73-8 12.639200145022
11073 Bisindolylmaleimide XI (hydrochloride) New 145333-02-4 ≥98% 2012-03-21 37.214390955495 bisindolylmaleimide-xi-hydrochloride Ro 32-0432 131848-98-1 Ro32-0432 Ro-32-0432 Ro-320432 Ro 320432 Ro320432 PKC isozymes Staurosporine inhibitors inhibits inhibition proteins kinases C PKCα PKCβI PKCε hydrochloride HCl cells hearts T-cell T cell inflammatory inflammation 37.214390955495
13124 BIX01294 (hydrochloride hydrate) - ≥98% 2009-12-03 37.100217184225 bix01294-hydrochloride-hydrate euchromatin genes expressions epigenetics G9a histones methyltransferase HMTase embryogenesis imprinting lymphocytes development inhibitors proteins GLP stem cells 935693-62-2 37.100217184225
13013 (−)-Blebbistatin 856925-71-8 ≥98% 2009-04-16 25.285276243094 -blebbistatin (S)-Blebbistatin inhibitors muscles myosin ATPase smooth muscle bleb apoptosis cell migration chemotaxis cytokinesis cells division growth UV light blebs (-)-(S)-Blebbistatin 25.285276243094
13165 (+)-Blebbistatin - ≥98% 2009-04-16 15.714917127072 -blebbistatin (R)-Blebbistatin inhibitors muscles myosin ATPase smooth muscle bleb apoptosis cell migration chemotaxis cytokinesis cells division growth UV light (+)-(R)-Blebbistatin inhibition inhibited 15.714917127072
13186 (±)-Blebbistatin 674289-55-5 ≥98% 2009-06-09 62.848453038674 -blebbistatin inhibitors muscles myosin ATPase smooth bleb apoptosis cells migration chemotaxis cytokinesis division growth UV lights 62.848453038674
10155 BM 567 284464-77-3 >98% 2005-03-31 43.370676795580 bm-567 platelets thromboxanes TXA2 atherosclerosis synthases inhibits inhibition inhibitors antagonists BM567 BM-567 thrombogenic vasocontrictors TP receptors eicosanoids strokes myocardial infarctions GPCR vascular smooth muscles protein-coupled license:liege 43.370676795580
10488 Bupropion (hydrochloride) 31677-93-7 ≥98% 2010-08-16 6.125262942501 bupropion-hydrochloride NSC 315851 34841-36-6 Zyban Wellbatrin inhibitors inhibits inhibition reuptake dopamine norepinephrine Voxra Aplenzin Amfebutamone antagonists neuronal acetylcholine nicotinic receptors nAChR antidepressant depression neurosciences Wellbutrin 1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone GlaxoSmithKline Brand 2 of Bupropion Hydrochloride GlaxoSmithKline Brand 1 of Bupropion Hydrochloride Glaxo Wellcome Brand 3 of Bupropion Hydrochloride Glaxo Wellcome Brand 2 of Bupropion Hydrochloride Glaxo Wellcome Brand 1 of Bupropion Hydrochloride Esteve Brand of Bupropion Hydrochloride Bupropion Hydrochloride Bupropion Hydrochloride Zyban (Anti-Smoking) Amfebutamone Wellbutrin Bupropion Bupropion Zyntabac Quomen Isomer 6.125262942501
13285 Cannabidiol dimethyl ether 1242-67-7 ≥98% 2009-05-19 8.183425414364 cannabidiol-dimethyl-ether Cannabidiol-2',6'-dimethyl ether; CBDD 15-lipoxygenases 15-LOs dioxygenase fatty acids inflammation thrombosis cancer LDL oxidation inhibitions inhibition inhibiting cannabinoids cbs synthetic 8.183425414364
11313 Castanospermine New 79831-76-8 ≥98% 2012-01-31 21.092349336381 castanospermine 6,7-Diepicastanospermine; 6-Epicastanospermine; NSC 625381; 1,6,7,8-Tetrahydroxyoctahydroindolizine inhibitors inhibits inhibition glucosidases glycogen glycosylation glycoproteins complex carbohydrates viruses infections lysosomes angiogenesis proteins cells NSC625381 NSC-625381 BML-S107 BMLS107 BML S107 21.092349336381
70130 CAY10397 78028-01-0 >98% 41.409060773480 cay10397 CK47A inhibitors inhibits 15-hydroxy prostaglandins dehydrogenases 15-OH-PGDH PG15DH 15-hydroxy-PGDH 41.409060773480
70210 CAY10404 - >98% 33.684031102925 cay10404 COX-2 inhibitors PGHS-2 COX2 PGHS2 prostaglandins synthases NSAIDS selective selectivity inhibits inhibition cyclooxygenase 33.684031102925
70635 CAY10416 443919-96-8 >95% 2007-07-24 31.926498618784 cay10416 COX-2 cyclooxygenases 5-LO lipoxygenases inflammation inhibitors prostates cancers PC3 LNCaP carcinomas apoptosis inhibition inhibits chemotherapy cells lines 31.926498618784
10008657 CAY10502 Exclusive - ≥98% ✓ 2007-08-02 3.096629834254 cay10502 cPLA2.alpha. phospholipases inflammation inhibitors inhibits inhibition arthritis inhibitory cPLA2 AA arachidonic inflammatory inflammation 3-methyl hydrogen 1-[3-(4-decyloxy phenoxy)-2-oxopropyl] indole-3,5 dicarboxylate 3.096629834254
10009078 CAY10505 328960-84-5 ≥98% 2009-11-04 7.700023327194 cay10505 phosphoinositide 3-kinase immunity autoimmune inflammation PI3Kγ PI3Kα PI3Kβ PI3Kδ casein kinases 2 CK2 phosphorylation PKB/Akt macrophages neutrophil recruitment cancer PI3s T2Ds PI3Ks PI3K.gamma. PI3Kg 7.700023327194
10010088 CAY10526 Exclusive 938069-71-7 ≥98% ✓ 2007-09-07 383.213084714549 cay10526 mPGES-1 mPGES1 microsomal prostaglandin E2 PGE2 synthase prostanoid modulators inflammatory inflammation pain inhibition inhibitors inhibits expressions 383.213084714549
10010740 CAY10550 34320-83-7 ≥98% 2008-07-14 4.120286602210 cay10550 3-(4-Nitrophenyl)-1-phenyl-2-pyrazolin-5-one prion PrPc PrPsc PrPres mad cow disease scrapie creutzfeldt-jakob disease spongigorm encephalopathy radical scavenger inhibitors inhibits inhibition 4.120286602210
10010301 CAY10554 267654-00-2 ≥95% 2007-12-01 10.028232044198 cay10554 BML-259 cell cycle cdk5 cdk2 inhibitors inhibits inhibition cancers BML 259 BML259 CDKs neurodegenerative diseases 10.028232044198
10010043 CAY10561 Exclusive 933786-58-4 ≥98% ✓ 2008-03-06 13.732486187846 cay10561 Pyrazolylpyrrole ERK Inhibitor MEK Ras Raf ERK2 proliferation cell cycles cancers apoptosis inhibition inhibit inhibitors 13.732486187846
10012562 CAY10566 944808-88-2 ≥98% 2009-01-07 8.920441988950 cay10566 SCD1 long chain fatty acids monounsaturated type 2 two diabetes dyslipidemia obesity 8.920441988950
10010233 CAY10567 32387-96-5 ≥98% 2008-05-06 3.418232044199 cay10567 BML-257 Akt1 inhibitors inhibits inhibition translocations HCV hepatitis signal transduction signaling signalling 3.418232044199
10010032 CAY10570 Exclusive 875014-22-5 >98% ✓ 2008-06-03 11.915980662983 cay10570 FAAH fatty acids amides AEA anandamides CB1 inhibitors inhibits inhibition endocannabinoids hydrolases cannabinoids 11.915980662983
10010400 CAY10571 152121-46-5 ≥95% 2008-08-11 20.886629834254 cay10571 MAPK signal transduction p38 kinases heat shock cytokines inflammation immuno response CSAID CSBP UL-1 IL1 5-LO 5LO 20.886629834254
18218 CAY10572 845714-00-3 ≥98% 2009-03-02 13.921418047882 cay10572 PHA 767491 inhibits inhibition inhibitors cdc7 kinases pyrrolopyridinone DNA synthesis cells death cycles apoptosis p53 cancers cdk9 antitumor agents anti-tumor 13.921418047882
10011247 CAY10574 140651-18-9 >95% 2008-09-04 13.999403314917 cay10574 CDK2 cyclin E CDK9 inhibitors inhibits inhibition anticancer cell cycle CAN508 13.999403314917
10011248 CAY10575 916985-21-2 ≥95% 2008-09-03 24.234925019731 cay10575 IKKε IKK-ε IKK-e IKKe NFkB inflammation immune response cytokine kinase inhibitors inhibits inhibition NF-κB 24.234925019731
10011249 CAY10576 862812-98-4 ≥95% 2008-09-08 31.565377532228 cay10576 IKK-.epsilon. IKK.epsilon. IKK-epsilon IKK-e IKKe NFkB inflammation immune response cytokine kinase inhibitors inhibits inhibition 31.565377532228
10011256 CAY10577 300675-28-9 ≥95% 2008-09-02 0.613259668508 cay10577 inhibitors inhibits inhibition CK2 kinase cell signaling apoptosis cancers 0.613259668508
10011264 CAY10578 19231-60-8 ≥95% 2008-08-26 0.613259668508 cay10578 inhibitors inhibits inhibition kinase cell signaling CK2 apoptosis cancers isoindolineacetic acids 0.613259668508
16838 CAY10581 Exclusive 1018340-07-2 ≥97% ✓ 2009-05-08 2.261049723757 cay10581 indoleamine 2,3-dioxygenase IDO cancers inhibitors tumors inhibition inhibited naphthoquinones 2.261049723757
13164 CAY10589 Exclusive 1077626-52-8 ≥98% ✓ 2009-06-23 2.900145027624 cay10589 Microsomal prostaglandin E2 synthase-1 mPGES-1 inhibitors cyclooxygenase cyclooxygenase-2 COX-2 PGE2 5-lipoxygenase 5-LO COX-1 leukotrienes LTB4 LTC4 LTD4 LTE4 dual inhibits inhibition inflammation fever pain signaling sagnalling 2.900145027624
13181 CAY10590 Exclusive 1101136-50-8 ≥98% ✓ 2009-04-15 14.872604577742 cay10590 sPLA2 cPLA2 iPLA2 phospholipases inhibitors R-gamma-nonleucine inhibition inhibited secreetory regulates phagocytosis foam cells 14.872604577742
13206 CAY10593 Exclusive - ≥95% ✓ 2009-09-03 34.926662983425 cay10593 VU0155069 inhibitors inhibits inhibitions phospholipases D PLD PLD1 PLD2 phosphatidic acids PAs chemotaxis cells migration cancers breast lines tumors trans well assays 1130067-06-9 34.926662983425
13207 CAY10594 Exclusive 1130067-34-3 ≥98% ✓ 2009-06-23 25.943215469613 cay10594 Phospholipase D PLDs PLD1 PLD2 phosphatidic acid PA inhibitors chemotaxis cells migration cancers breast cancer inhibition inhibited 25.943215469613
13381 CAY10606 1159576-98-3 ≥98% 2009-12-04 118.757262682069 cay10606 5-lipoxygenases 5-LOs leukotrienes LTs LTB4 arachidonic acids inhibitors inhibit neutrophils blood ionophore A23187 formyl peptides fMLP lipopolysaccharides LPS reversed pleurisy inflammation inflammatory inhibition 118.757262682069
10012694 CAY10607 Exclusive 1012788-65-6 ≥98% ✓ 2009-07-07 0.702774708410 cay10607 Benzisoxazole Hsp90 Inhibitor; BHI inhibitors inhibits inhibition heat shocks proteins cancers cells proliferation geldanamycin chaperones 0.702774708410
13358 CAY10608 Exclusive 457897-92-6 ≥98% ✓ 2010-04-29 1.305248618784 cay10608 N-Methyl-D-aspartate NMDA receptors antagonists glutamate glycine propanolamine NR2B subunit AMPA kainate neuroprotection neurochemistry antagonizes potently selectively non-competitively 1.305248618784
13615 CAY10614 Exclusive 1202208-36-3 ≥98% ✓ 2010-03-22 11.377624309392 cay10614 1115270-65-9 Lipids A endotoxins lipopolysaccharides LPS gram-negative bacterias infections toll-like receptor 4 TLR4 immune responses antagonists sepsis inflammation 11.377624309392
13291 CAY10616 Exclusive 586410-08-4 ≥98% ✓ 2009-12-01 19.682861878453 cay10616 resveratrols apoptosis cancers leukemia HL-60 cells HL60 HL 60 multidrug-resistance multidrug resistance multi-drug multi-drug-resistant daunorubicin etoposides citarabines phenols cytarabines HL60R 19.682861878453
13670 CAY10618 Exclusive 1202580-59-3 ≥95% ✓ 2011-03-18 12.005966850828 cay10618 NMPRTase Inhibitor nicotinamides phosphoribosyltransferases NAMPTs NAD+ cancers inhibitors autophagy inhibited inhibition inhibits 12.005966850828
13371 CAY10621 120005-55-2 ≥98% 2010-02-16 22.424627071823 cay10621 SKI 5C; SPHK 1 Inhibitor 5C sphingosines kinases Sphk sphingosine-1-phosphates S1P SphK1 SphK2 cancers inhibitors inhibits U937 cells proteins kinase C PKC SKI5C SKI-5C 22.424627071823
13687 CAY10622 Exclusive 1038549-25-5 ≥98% ✓ 2010-10-18 20.910441988950 cay10622 Rho kinases ROCK-I ROCK-II inhibitors inhibits inhibition 20.910441988950
13836 CAY10625 137346-42-0 ≥95% 2010-06-23 2.702464088397 cay10625 apoptosis Smac Diablo Survivin cancers antagonists INCENP doxorubicin caspase-3 caspase-7 Aurora B kinases Borealin caspases cell-permeable antagonists smac/diable smac-diablo 2.702464088397
13838 CAY10626 Exclusive 1202884-94-3 ≥98% ✓ 2010-08-23 12.047810517699 cay10626 PI3Kα mTOR cancers signal transduction inhibitors inhibits inhibition phosphatidylinositol 3-kinase PtdIns PIs 12.047810517699
13695 CAY10638 Exclusive - ≥98% ✓ 2010-10-01 25.700034530386 cay10638 Thiazolidinedione derivative prostaglandins 15-PGDHs thiazolidinediones inhibitors inhibits inhibition TZDs derivatives PGDHs dehydrogenases 25.700034530386
10791 CAY10647 Exclusive New - ≥98% ✓ 2012-04-16 57.198422021906 cay10647 cancers inhibitors inhibits inhibition tumors tubulin polymerization cells CAY-10647 CAY 10647 growth 57.198422021906
10804 CAY10649 Exclusive 1272519-89-7 ≥98% ✓ 2011-04-04 16.559235727440 cay10649 5-LO leukotrienes 5-lipoxygenases inhibitors inflammation smooth muscle contraction inhibition inhibited PMNL inflammatory 16.559235727440
10743 CAY10650 Exclusive 1233706-88-1 ≥98% ✓ 2011-06-14 12.111933701657 cay10650 cPLA2α cPLA2 inhibitors inflammation anti-inflammatory dermatitis metabolite phospholipase cytosolic prostaglandins PGs leukotrienes synthesis 10662 CAY-10650 CAY10641 CAY-10641 12.111933701657
10857 CAY10654 Exclusive 1298023-69-4 ≥98% ✓ 2011-06-21 1.903637200736 cay10654 CAY-10654 CAY 10654 quorum sense sensing signal signaling genes regulations infectious diseases lipids bacteria pseudomonas aeruginosa AHLs p. N-acylated-L-Homoserine lactones transcriptional activators LasR virulence factors immunosuppression leukocytes lymphocytes concanavalin A cytotoxicity 1.903637200736
11140 CAY10657 New 494772-86-0 ≥98% 2012-03-05 15.173864708261 cay10657 NF-κB, transcription factors inflammation arthritis chemotherapy IKK IKK2 inhibitors IKB thiophenecarboximide inhibits inhibitions IKK-2 IKK 2 NFkB NF kB Rel NF-kB/Rel pro-inflammatory genes cytokines chemokines interferons MHC proteins growth factors cells adhesion cancers 15.173864708261
13172 CBHA 174664-65-4 ≥98% 2009-06-24 20.309815262430 cbha Histone Deacetylase Inhibitor II; m-Carboxycinnamic Acid bis-Hydroxamide histones deacetylase HDACs HDAC1 HDAC3 apoptosis cancers neuroblastoma tumors retinoic acids inhibitors inhibits inhibition 20.309815262430
10787 CCG-100602 1207113-88-9 ≥98% 2011-11-22 6.028416206261 ccg-100602 Rho signaling signal transduction cancers inhibitors SRF serum response factors transcription CCG-1423 megakaryoblastic leukemia 1 MKL1 prostate analogs PC-3 CCG100602 CCG 100602 CCG1423 CCG 1423 cells DNA binding RHOA/C-mediated MKL-1 6.028416206261
10010350 CCG-1423 285986-88-1 ≥98% 2007-09-20 10.328705603788 ccg-1423 Rho signaling transduction cancers proliferations anti-proliferation anti-tumor serum response factor GTPase inhibits inhibitors inhibition signalling 10.328705603788
10012591 CCT018159 171009-07-7 ≥98% 2008-12-09 1.092651933701 cct018159 inhibitors inhibits inhibition cancers Hsp90s Hsp72 kinases tumor cells 17-AAG 17AAG CCT 018159 CCT-018159 1.092651933701
13519 Celastramycin A Exclusive 491600-94-3 ≥97% ✓ 2010-01-25 1.674033149171 celastramycin-a inhibits inhibitors bacterias mycobacterias inflammation IL-8 IL 8 IL8 HUVECs endothelial cells TNF-α TNFα TNF α inhibition interleukins tumors necrosis factors TNF alpha TNF.alpha. inflammatory bioactive endophytic celastraceae pyrroles 1.674033149171
11092 Ceranib-2 New - ≥98% 2011-12-19 5.143965738907 ceranib-2 ceramides ceramidase sphingosines sphingosine-1-phosphate S1P cells proliferation cancers paclitaxel tumors inhibitors lipids inhibits inhibition endogenous ovarian SKOV3 growth toxicity fatty acids N-acyl malignant apoptosis S1P non-lipid increases increased 5.143965738907
13322 CGP 57380 522629-08-9 ≥95% 2009-08-28 32.518664825046 cgp-57380 MNK1 Inhibitor inhibitors inhibits inhibitions MAPKs MAP kinases interacting interacting-kinase 1 MNK1 p38 JNK1 ERK1/2 PKC Src-like phosphorylation elF4E TNF-a TNF-α TNFα TNFa arsenite anisomycin PMA fetal calf serum 293 cells RAW264.7 toll-like receptors TLR2 HKLM TLR4 LPS TLR6/2 FSL TLR7 imiquimod TLR9 CpG DNA CGP57380 CGP-57380 32.518664825046
13156 Chaetocin 28097-03-2 ≥95% 2010-10-18 18.632886024146 chaetocin histones methyltransferases HMTs genes expressions epigenetics inhibitors oxidative stress cancers theoredoxin reductase-1 TrxR1 inhibits inhibition chetocin chaetocin A (+)-chaetocin piperazines 18.632886024146
11314 Chelerythrine chloride New 3895-92-9 ≥98% 2012-01-31 6.179201541034 chelerythrine-chloride NSC 646662; Broussonpapyrine chloride 6004-02-0 84282-43-9 chelerythrinium inhibitors inhibits inhibition PKC apoptosis cells signaling BclXL Bcl-2 cancers tumors p38 MAP kinases proteins JUNK benzophenanthridine alkaloids AC328200010 hydrochloride chlorid EINECS 223-444-9 2234449 3895-92-9 NSC 36405 NSC-36405 NSC36405 6.179201541034
13686 Chidamide 743420-02-2 ≥98% 2010-08-10 39.909907100471 chidamide HDACs histones deacetylase H3 acetylation colons cancers cells inhibitors inhibits inhibiton LoVo HT-29 HT29 HT 29 cycle arrest chidamides oncogenic signalling signaling kinases Benzamides 39.909907100471
13122 CHIR99021 252917-06-9 ≥98% 2011-02-18 100.590852407261 chir99021 CT 99021 GSK-3α GSK-3β inhibitors glucose metabolism insulin diabetes Wnt stem cells mice mouse CHIR-99021 CT-99021 CHIR 99021 CT99021 pyridines glucogen synthesis CHO-IR self-renewal 100.590852407261
11021 CHS-828 New 200484-11-3 ≥98% 2012-03-14 21.684931506849 chs-828 GMX 1778 pyridyl cyanoguanidine anti-tumor tumors inhibitors inhibits inhibition NAMPT NF-κB cancers CHS828 CHS 828 humans breasts lungs mice MCF-7 NYH GMX-1778 GMX1778 21.684931506849
10858 Cinnamyl-3,4-dihydroxy-α-Cyanocinnamate 132465-11-3 ≥97% 2011-06-28 17.917223756906 cinnamyl-3-4-dihydroxy-cyanocinnamate CDC inhibitors 5-LO 5LO 12LO 15LO 5 LO 12 LO 15 LO 12-LO 15-LO LTB4 lipoxygenases immune responses inflammation inhibits inhibition A23187 platelets shock assays 17.917223756906
10012583 cis-ACCP 777075-44-2 ≥95% 2009-02-10 0.085082872928 cis-accp MMP2 MMPs MMP 2 MMP9 MMP-9 9 tumors cancers extracellular matrix type IV collagen cell migration artritis osteoprosis 0.085082872928
10004235 cis-Resveratrol 61434-67-1 >98% (may contain 1-5% trans) 2008-02-05 30.205534069981 cis-resveratrol (Z)-Resveratrol antioxidant oxidative stress reactive oxygen species reactive nitrogen species ROS RNS NF-kb inflammations monoamine oxidase noradrenaline inhibits inhibitor inhibitions NF.kappa. atherosclerosis sirtuins AHR antagonists aryl hydrocarbon receptors 30.205534069981
10599 Cl-Amidine Exclusive 913723-61-2 ≥95% ✓ 2011-08-29 37.217651933702 cl-amidine inhibitors PAD4 PAD-4 cancers epigenetics amidines proteins arginine deiminase 4 arthritis PADs cytotoxic HL-60 HL60 HT-29 mice joints auto antibodies HL 60 MCF7 MCF-7 MCF 7 HT29 citrulline IgG HT 29 cells lines ClA mouse serum autoantibodies auto-antibodies PAD3 PAD-3 3 PAD1 PAD-1 1 37.217651933702
70988 Clasto-Lactacystin β-lactone 154226-60-5 ≥98% 37.226201657458 clasto-lactacystin-lactone Omuralide; β-Clastolactacystin selective inhibitors neuroblastoma pleiotropic neurites 20S proteasomes inhibits streptomces cells Neuro2A apoptosis inhibition death 37.226201657458
9000760 Colchicine 64-86-8 ≥98% 2011-05-25 19.853603437692 colchicine microtubules polymerization mitosis anti-proliferation anti-inflammatory gout uric acids antiinflammatory antiproliferation 19.853603437692
10007412 Combrestatin A4 117048-59-6 ≥98% 2007-07-26 25.305512584407 combrestatin-a4 Combretastatin A4; CRC 87-09; CA4 inhibitors inhibition inhibits tubulin polymerization tumors CSA4 CSA-4 IMR32 neuroblastomas Hs746T carcinomas CFPAC-1 CFPAC1 MCF-7 MCF7 cancers inhibitory CA4 cells growth pancreatic breast gastric CA-4 combretastin 25.305512584407
11050 Concanamycin A New 80890-47-7 ≥95% 2012-03-21 29.277777777778 concanamycin-a X 4357B; NSC 674620; Antibiotic X 4357B 66771-59-3 NSC674620 NSC-674620 X-4357B X4357B vacuolar H+-ATPase V-type proton pumps inhibitors inhibits inhibition pH lysosomes endosomes V1 V0 domains plecomacrolide antibiotics Streptomyces viral glycoproteins influenza viruses cells 29.277777777778
10186 COX Inhibitor Pack - ≥98% 38.553922651933 cox-inhibitor-pack Cyclooxygenase-PAK cyclooxygenases PGHS-2 inducible synthases prostaglandins CAY10404 SC-560 SC-58125 valeroyl saliylate NS-398 aspirin resveratrol APHS inhibitors inhibits inhibition SC560 SC58125 NS 398 COX-2 COX2 COX-1 COX1 PGHS2 PGHS-1 PGHS1 10186 70330 70655 10006120 10007692 valdecoxib licofelone packs 38.553922651933
13183 CP 80633 135637-46-6 ≥98% 2010-05-20 10.566906077348 cp-80633 phosphodiesterases PDE cAMP cGMP asthma neurological diseases inhibitors inhibits inhibition PDE4 PDE1 PDE2 PDE3 PDE5 inflammation CP-80,633 CP-806333 CP80633 Pyrimidinones Pyrimidones 10.566906077348
11326 Cyclopiazonic Acid New 18172-33-3 ≥95% 2012-02-23 38.231529337214 cyclopiazonic-acid NSC 117181 inhibitors SERCA calcium Ca2+-ATPase ATPases smooth muscles endothelial cells endothelium cardiovascular vascular biology cardiology mycotoxins Penicillium Aspergillus NSC117181 NSC-117181 38.231529337214
11328 Cytochalasin B New 14930-96-2 ≥98% 2012-02-22 31.016864586462 cytochalasin-b Phomin; NSC 107658 11032-95-4 11042-65-2 16006-03-4 21476-12-0 inhibitors actin proliferation migration phagocytosis glucose exocytosis cells division chemotaxis inhibits inhibition mycotoxins polymerization NSC-107658 NSC107658 31.016864586462
13305 D 4476 301836-43-1 ≥98% 2009-07-29 39.871657458563 d-4476 Casein Kinase I Inhibitor inhibitors inhibits inhibition casein kinases 1 CK1 Ck1δ TGF-β TGFβ type-1 receptors ALK5 PKD1 p38α MAPK kinases phosphorylation FOXO1a RhoB p53 Smad3 D4476 39.871657458563
13197 DAPT 208255-80-5 ≥95% 2010-09-16 16.308718232044 dapt GSI-IX amyloids precursors proteins APP Notch beta amyloid Aβ Alzheimer’s disease inhibitors inhibits inhibition γ-secretase Aβ42 cells signaling signals differentiation GSIIX GSI IX Dipeptides 16.308718232044
11166 Decitabine New 2353-33-5 ≥98% 2012-02-27 9.013102558266 decitabine Dacogen; 5-aza-2’-Deoxycytidine; NSC 127716; DAC β-decitabine 105597-46-4 123795-43-7 5-azadeoxycytidine 5-azadCyd 5-aza-CdR inhibitors inhibition inhibits epigenetics DNA methylation genes expression methyltransferases hypomethylation mutagenic 9.013102558266
11012 Delphinidin chloride Exclusive New 528-53-0 ≥98% ✓ 2012-03-06 51.662269285860 delphinidin-chloride Ephdine diseases cancers cardiovascular tyrosines kinases vasorelaxation smooth muscles chlorides Cl vasorelaxants inhibitors inhibition inhibits EGFRs epidermal epidermis growth factors receptors HATs histones acetyltransferases anthocyanidins plants pigments anthocyanins blue red colors flowers fruits wines nitric oxides NOs vascular endothelium signaling signalling epithelial estrogens ERa ERalpha ER.alpha. ERα apoptosis cells death autophagy phagocytosis delphinidol 13270-61-6 IdB 1056 IdB-1056 51.662269285860
10961 Demethoxycurcumin 22608-11-3 ≥98% 2011-09-23 4.766151012890 demethoxycurcumin DMC curcumin cancers transcription genes expressions p300 Wnt/β-catenin iNOS inflammation proliferation cells p300 coactivator inhibits lipopolysaccharides inhibitor inhibition 4.766151012890
70680 Diclofenac (sodium salt) 15307-79-6 ≥99% 18.282537685014 diclofenac-sodium-salt Voltaren; Ecofenac; Benfofen cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits 18.282537685014
9000556 Dimebolin Exclusive 3613-73-8 ≥98% ✓ 2010-01-12 0E-12 dimebolin Dimebon™ neurodegeneration Alzheimer's diseases Huntington's neuroprotection cognition inhibitors inhibition β-amyloid calcium channels NMDA glutamate receptors mitochondria dimebone dimeboline preparation 84 Dimebolin 12687-54-6 20684-30-4 inhibited Indoles 0E-12
10011349 Dimebolin (hydrochloride) 97657-92-6 ≥98% 2010-02-19 0E-12 dimebolin-hydrochloride neurodegeneration Alzheimer's diseases Huntington's neuroprotection cognition inhibitors inhibits inhibition calcium channles β-amyloid β amyloid NMDA glutamate receptors mitochondria dimeboline dimebon neurochemistry neuroscience Indoles 0E-12
81050 Diphenyleneiodonium Chloride 4673-26-1 ≥99% 13.092237569060 diphenyleneiodonium-chloride DPI Chloride nitric oxide synthases inhibitors iNOS eNOS dibenziodolium 13.092237569060
10010948 DL-Propargyl Glycine (hydrochloride) - ≥98% 2008-08-19 17.522989249343 dl-propargyl-glycine-hydrochloride PAG H2S gasotransmitter inhibitor inhibits inhibition CSE vasodilation inflammation propargylglycine 17.522989249343
11637 Docetaxel New 114977-28-5 ≥98% 2012-05-17 100.226746470227 docetaxel NSC 628503; RP 56976; Taxotel; Docetere; Taxotere 129522-72-1 216252-50-5 docetaxol taxol cancers breasts prostate cells proliferation microtubules replication hormones hormone-refactory refractory NSC628503 NSC-628503 RP56976 RP-56976 100.226746470227
9000639 Docosahexaenoyl Serotonin Exclusive 283601-58-1 ≥98% ✓ 2010-05-18 6.647182320442 docosahexaenoyl-serotonin N-arachidonoyl serotonin AA-5-HT AA-5HT antagonists fatty acids amide hydrolase FAAH transient receptors potential vanilloid-type 1 channels TRPV1 pain capsaicin ethanolamine anandamide AEA L-alpha-Glycerylphosphorylcholine L alpha Glycerylphosphorylcholine Glycerophospholipids Choline Choline Glycerophospholipids Phosphoglycerides Choline 3-Phosphocholine Glycerol Glycerylphosphorylcholine Glycerophosphate Choline Glycerol 3-Phosphocholine Glycerol 3 Phosphocholine Choline Phosphoglycerides Glycerophosphorylcholine Choline Glycerophosphate Alphoscerate Choline Phosphatidylcholines Choline Alphoscerate Alfoscerate Choline Phosphatidylcholine Choline Alfoscerate 6.647182320442
13245 Donepezil 120014-06-4 ≥95% 2010-03-08 5.069640883978 donepezil Aricept® acetylcholine neurotransmitters acetylcholinesterase inhibitors inhibits inhibition central nervous system Alzheimer's diseases cognition memory dementia Donezepil signaling signalling AchE CNS behavior (±)-E 2020 (+/-)-E 2020 E2020 5.069640883978
10460 Doramapimod 285983-48-4 ≥98% 2011-06-02 19.724613259668 doramapimod BIRB-796 p38 MAPKs inflammation TNFα TNF-α TNF α TNFalpha TNF-alpha TNF alpha JNKs inhibitors proteins kinases tumors necrosis factors LPS THP.1 cells THP1 BIRB796 BIRB 796 mitogen activated mitogen-activated proinflammatory cytokins interleukin-1 IL IL-1 interleukin 1 19.724613259668
10010302 DRB 53-85-0 ≥98% 2008-01-21 4.993093922652 drb Benzimidazole; NSC 401575 cancers HIV P53 apoptosis CDK7 CDK9 CTD CKI CKII adenosine inhibitors inhibits inhibition transcription RNA polymerase cell cycles adenocarcinoma transactivator tat 4.993093922652
70645 DuP-697 88149-94-4 ≥96% 16.836245856353 dup-697 COX-2 COX2 PGHS2 prostaglandins H synthases inhibitors inhibits selective time-dependent cyclooxygenase DuP697 DuP 697 16.836245856353
10007963 E-64 66701-25-5 ≥98% 2009-11-12 28.585893186004 e-64 inhibitors cysteine proteases cathepsins papain calpain irreversible inhibition inhibited E64 E 64 28.585893186004
10007964 E-64c 76684-89-4 ≥98% 2006-08-02 27.459705340700 e-64c EP 475; Loxistatin Acid; NSC 694279 E-64 cysteine protease cell cycle inhibitor E-64d 27.459705340700
13533 E-64d 88321-09-9 ≥98% 2010-08-16 17.218066298343 e-64d EP 453; EST; NSC 694281; Loxistatin; E-64c ethyl ester; Aloxistatin cysteine protease proteins degradation lysosome inhibitors inhibits inhibition calpain cathepsin E64d E 64d 64 207396-71-2 cells cancers carcinomas A431 E-64d Morphinans 17.218066298343
70530 Ebselen 60940-34-3 ≥99% 214.395948434622 ebselen glutathione peroxidase peroxynitrite oxidative injury stress cyclooxygenases lipoxygenases LOX 5-LO 12-LO 15-LO cyclooxygenases inhibitors COX-1 COX-2 cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits mimics scavengers 214.395948434622
11049 Echinomycin New 512-64-1 ≥98% 2012-03-21 41.796717171717 echinomycin NSC 13502; SK 302B; NSC 526417; Antibiotic A 654I; Quinomycin A 11016-61-8 NSC13502 NSC526417 NSC-13502 NSC-526417 SK302B SK-302B hypoxia HIF-1 cancers neuroscience VEGF inhibitors inhibits inhibition genes expression glycolysis angiogenesis migration invasion cells DNA HIF-1α HIF-1β U215 hippocampal neurons myeloma melphalan 41.796717171717
13352 EHNA (hydrochloride) 58337-38-5 ≥98% 2011-10-07 766.115469613259 ehna-hydrochloride 51350-19-7 79763-32-9 59262-86-1 ADA reversible adenosine deaminase inhibitors inhibits inhibition cGMP PDE2 potent PDE1 PDE3 PDE4 phosphodiesterase ardioprotective ischemia stem cells 766.115469613259
9000640 Eicosapentaenoyl Serotonin Exclusive 199875-71-3 ≥98% ✓ 2010-09-10 2.566314127861 eicosapentaenoyl-serotonin N-arachidonoyl serotonins AA-5-HT AA5HT AA 5 HT AA-5HT AA5HT antagonists fatty acids Amide hydrolase FAAH transient receptors potential vanilloid type 1 channels TRPV1 pain capsaicin ethanolamine anandamide AEA Triacylglycerols Triacylglycerol Triglycerides 2.566314127861
90120 Eicosatetraynoic Acid 1191-85-1 >98% 6.291104972375 eicosatetraynoic-acid ETYA inhibitors inhibits lipoxygenases cyclooxygenases prostaglandin h synthases cox lo acetylene PPAR ligands peroxisome proliferator-activated receptors fatty acids 6.291104972375
10569 Ellagic Acid 476-66-4 ≥95% 2010-10-13 8.133806015960 ellagic-acid Lagistase; TBBD; Gallogen polyphenols, antioxidants, cancers inflammation cytochrome P450s CYP450 epigenetics genes expression histones modifications alizarin yellow G 91006 elagostasine 77415-21-5 124590-32-5 PRMTs inflammatory anti-carcinogenic anti-mutagenic organ-preserving antimutagenic antiinflammatory Acid Benzoaric Benzoaric Acid Acid Ellagic Ellagic Acid 8.133806015960
10010571 Entacapone-d10 - ≥98% 2008-04-14 11.348867403315 entacapone-d10 Parkinsons dieseases inhibitors inhibits inhibition SPI nitrocatechols catechol-o-methyl blood-brain barrier neurochemistry 11.348867403315
10924 Epothilone B 152044-54-7 ≥95% 2011-07-27 21.490939226520 epothilone-b macrolides inhibitors inhibits inhibition tubulin microtubules polymerization cancers cells cycle mitotic arrest mitosis Hs578T HeLa KB3-1 KB31 KBV-1 KBV1 cytoskeletal 21.490939226520
10007806 Epoxomicin 134381-21-8 ≥98% 2008-12-09 57.390685082873 epoxomicin BU 4061T inhibitors inhibits inhibition proteins degradation 20S proteasomes antitumors bones formation Parkinsons diseases anti-tumors 57.390685082873
10010238 Erbstatin Analog 63177-57-1 ≥98% 2008-06-06 0.437569060774 erbstatin-analog Methyl 2,5-dihydoxycinnamate analogs EGF EGFR inhibitors inhibits inhibition tyrosine kinase DNA synthesis cell cycle proliferation cancers 0.437569060774
10483 Erlotinib 183321-74-6 ≥98% 2010-08-11 27.513535911602 erlotinib Tarceva™; CP 358,774; NSC 718781 tyrosine kinase inhibitor inhibits inhibiting epidermal growth factor receptors EGFR cancers tumor cyclin-dependent cyclin dependent kinase 2 CDK-2 CDK 2 CDK2 JAK-2 JAK2 JAK JAK2V617F CP-358,774 CP-358774 CP 358774 CP358774 CP358,774 NSC-718781 NSC718781 OSI-744 OSI744 R-1415 R1415 R 1415 OSI 744 Quinazolines 27.513535911602
10012088 Ethyl-L-NIO (hydrochloride) 150403-97-7 ≥95% 2008-08-14 10.224350828729 ethyl-l-nio-hydrochloride L-N5-(1-Iminobutyl)ornithine hydrochloride nitric oxide synthase NOS iNOs nNOS selective inhibitors inhibits inhibition 10.224350828729
10009798 EX-527 49843-98-3 ≥98% 2009-10-23 28.387292817679 ex-527 sirtuins SIRT1 histones deacetylase HDAC energy metabolism inflammation inhibitors p53 DNA damage 848193-68-0 848193-69-1 28.387292817679
10610 F-Amidine (trifluoroacetate salt) Exclusive - ≥95% ✓ 2011-09-23 28.482596685083 f-amidine-trifluoroacetate-salt proteins arginine deiminase 4 PAD4 cancers arthritis inhibitors histones genes expression cysteine PAD1 PAD3 cytotoxic HL-60 MCF7 HT-29 877617-46-4 PADs PAD-1 PAD-3 PAD-4 peptidyl arginine 28.482596685083
10010501 Farnesyl Thiosalicylic Acid 162520-00-5 ≥96% 2008-06-02 18.336316758748 farnesyl-thiosalicylic-acid Salirasib; FTS ras inhibitors inhibition inhibits cancer anti-cancer anticancer prenylation farnesylation signal transduction oncogene atherosclerosis farnesylthiosalicylic acid 18.336316758748
13175 Farnesyl Thiosalicylic Acid Amide Exclusive 1092521-74-8 ≥96% ✓ 2009-02-26 17.489226519336 farnesyl-thiosalicylic-acid-amide Salirasib Amide; FTS Amide Ras degradation cells signaling signalling tumors glioblastoma cancers inhibitors inhibits inhibition 17.489226519336
13563 FIPI Exclusive 939055-18-2 ≥98% ✓ 2010-03-24 32.235558011049 fipi 5-Fluoro-2-Indolyl des-Chlorohalopemide Phospholipases D PLD phosphatidic acids PA Ras activation cells spreading stress fiber formation chemotaxis membrane vesicles trafficking halopemide inhibitors inhibits inhibition PLD1 PLD2 F-actin cytoskeletons inflammation arthritis Pharmascience Brand of Domperidone Maleate Stadapharm Brand of Domperidone Maleate Ratiopharm Brand of Domperidone Maleate Taxandria Brand of Domperidone Maleate Novopharm Brand of Domperidone Maleate Nu-Pharm Brand of Domperidone Maleate Nu Pharm Brand of Domperidone Maleate Apotex Brand of Domperidone Maleate Hexal Brand of Domperidone Maleate Aliud Brand of Domperidone Maleate Teva Brand of Domperidone Maleate Pierre Fabre Brand of Domperidone Gry Brand of Domperidone Maleate Rottapharm Brand of Domperidone Monohydrochloride, Domperidone Domperidone Monohydrochloride Janssen Brand of Domperidone Domperidone Maleate (1:1) Maleate, Domperidone Domperidone Maleate Gamir Domperidona Stada Domperidon ratio-Domperidone ratio Domperidone Hexal Domperidon Domperidona Gamir Novo-Domperidone Novo Domperidone Domperidon Stada Domperidon Hexal PMS-Domperidone PMS Domperidone Domperidon-TEVA Domperidon TEVA Apo-Domperidone Apo Domperidone Nu-Domperidone Nu Domperidone Domperidon AL Domperidone Gastrocure Domperidon R-33,812 Nauzelin Motilium R-33812 R33,812 Péridys Domidon R33812 32.235558011049
13287 FK-866 658084-64-1 ≥98% 2009-07-21 68.100817679557 fk-866 K 22.175 nicotinamides phosphoribosyltransferase NAMPT NamPRT PBEF visfatin mononucleotides adenine dinucleotide NAD+ inhibitors inhibitis inhibition cancers apoptosis SIRT1 autophagy FK866 FK 866 K22.175 K 22175 K22175 NamPRT PBEF visfatin carcinoma cells autophagy 68.100817679557
13179 FKGK 11 1071000-98-0 ≥98% 2009-06-30 21.816983425414 fkgk-11 Phospholipases A2 iPLA2 inhibitors signal transduction inhibition PLAs 21.816983425414
70250 (±)-Flurbiprofen 5104-49-4 ≥99% 52.414400450173 -flurbiprofen Ansaid cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases neurochemistry synthase-1 synthase-2 inhibits 51543-38-5 52.414400450173
10010337 Fluvastatin (sodium salt) 93957-55-2 ≥98% 2008-02-27 12.486676751732 fluvastatin-sodium-salt atherosclerosis HMG-CoA reductases LDL LDL-c HDL HDL-c statin cholesterol heart disease CVD inhibitors inhibits inhibition 12.486676751732
10039 FR122047 (hydrate) - ≥98% 13.770676795580 fr122047-hydrate 130717-51-0 FR-122047 cyclooxygenases COX-1 inhibitors hydrates hydrochlorides COX1 PGHS1 PGHS-1 prostaglandin synthases inhibition inhibits selective selectivity platelet aggregation antiinflammatory atherosclerosis 13.770676795580
11332 Fumagillin New 23110-15-8 ≥95% 2012-02-22 0E-12 fumagillin NSC 9168; Amebacilin 297-95-0 47721-00-6 47721-01-7 106215-84-3 746540-00-1 fugillin fumadil B fumagillin fumagillin DCH fumidil microsporidia inhibitors angiogenesis cancers cells growth proliferation genes expression fungus infection infectious diseases adipose tissues obesity Aspergillus fumigatus MetAP2 antibiotics 0E-12
11030 Fumitremorgin C New 118974-02-0 ≥98% 2012-03-30 37.777777777778 fumitremorgin-c Tryptoquivaline 12α-fumitremorgin C cancers multidrug resistance transporters inhibitors inhibition inhibits efflux toxicity breasts proteins BCRP/ABCG2 mitoxantrone doxorubicin topotecan S1-M1-3.2 colon carcinoma cells ABCB1 MRP1 ABCC1 P-glycoproteins fumitremorgin-C 37.777777777778
13227 Fumonisin B2 116355-84-1 ≥98% 2009-11-11 52.513377163045 fumonisin-b2 mycotoxins fungus corn grains sphingosines inhibitors N-acyltransferase apoptosis sphingolipids hepatotoxicity nephrotoxicity fungi fumonisin-B2 D02.455.326.146.432 CCRIS4434 CCRIS-4434 CCRIS 4434 AR-1D1013 LS-121074 AC1MBZ19 CHBI:38225 LMSP01080023 NCGC00163557-01 C19242 52.513377163045
70540 Furegrelate (sodium salt) 85666-17-7 ≥99% 2.544290976059 furegrelate-sodium-salt U-63557A thromboxanes synthases inhibitors inhibits inhibition salts atherosclerosis 2.544290976059
13200 G-418 Sulfate 108321-42-2 ≥95% 2009-11-09 29.444444444444 g-418-sulfate Geneticin aminoglycoside antibiotic gentamicin transfection stable transfectants engineered 49863-47-0 7664-93-9 49662-05-7 29.444444444444
10008346 Gabapentin 60142-96-3 ≥98% 2006-04-20 3.915138121546 gabapentin Neurontin® antiepileptic drugs Gamma-aminobutyric acids GABA neurotransmitters receptors spinal cord analogs anticonvulsants analgeics neuropathics pain syndromes Complex Regional types CRPS1 multiple sclerosis dysesthesias cancers HIV infections CNS central nervous systems calcium channels .gamma.-aminobutyric g-aminobutyric neurochemistry 3.915138121546
10566 Garcinol 78824-30-3 ≥95% 2011-10-25 9.634610820401 garcinol Camboginol inhibits inhibitors inhibition histones acetyltransferases HATs p300 PCAF GCN5 neurogenesis stem cells apoptosis cancers antiinflammatory anti-inflammatory inflammation neuroscience genes expressions regulations epigenetics 9.634610820401
13166 Gefitinib 184475-35-2 ≥98% 2010-02-11 21.037874382088 gefitinib Iressa™; ZD1839 EGFR-TK EGFRs TKs epidermal growth factors inhibitors cancers signal transduction tyrosine kinases inhibits inhibited NSCLC Quinazolinones 21.037874382088
13355 Geldanamycin 30562-34-6 ≥98% 2010-07-29 35.265105447297 geldanamycin NSC 122750 NSC 212518 antibiotics heat shock proteins 90 Hsp90 GRP94 gp96 genes expression cells proliferation apoptosis angiogenesis c-jun adenocarcinoma cancers AP-1 steroids receptors 2,5-Cyclohexadiene-1,4-Diones 1,4-Benzoquinones 1,2-Benzoquinones p-Benzoquinones-o-Benzoquinones Benzoquinones Benzodiones Quinones geldanomycin GDM NSC122750 NSC-122750 NSC 122750 AC-6794 BRN 1633093 geldanamicin 30562-34-6 antibiotic U29135 U-29135 U 29135 AC1NQZ81 ligands GRP94 Hsp 90 35.265105447297
11690 Gemcitabine New 95058-81-4 ≥98% 2012-05-23 97.777777777778 gemcitabine LY 188011; NSC 613327; Gemcel; Zefei; GemLip; Folfugem; Gemzar; DDFC nucleosides analogs anticancer non-small cells lungs pancreatic bladder breasts cancers anti-tumor tumors replication repair Gadd45a DNA demethylation antiretroviral AIDS 1239668-67-7 DFdC DFdCyd gamcitabine LY-188011 NSC613327 NSC-613327 LY188011 Gadd45a 97.777777777778
10010622 Genipin 6902-77-8 ≥98% 2008-05-09 144.961325966851 genipin (+)-Genipin obesity diabeties glucose insulin mitochondria UCP2 pancreatic .beta. cells anti-inflammatory antiinflammatory angiogenesis inhibitors inhibits inhibition uncoupling proteins 2 un-coupling angiogenesis apotosis diabetes inflammation metabolism obesity 144.961325966851
10948 GN25 New 1227401-27-5 ≥98% 2011-11-30 135.781546961326 gn25 tumors suppressors p53 cancers K-Ras Snail inhibitors mutations exocytosis cells proliferatiion analogs MKN-45 MKN45 MKN 45 A549 HCT116 GN-25 GN 25 genes humans 2-thio-dimethoxy naphthoquinone binding tumors 135.781546961326
13311 Gö 6983 133053-19-7 ≥98% 2009-10-07 9.212635422620 g-6983 proteins kinases C PKC α β γ δ ζ µ hearts cardioprotection ischemia reperfusion injuries contractile dyfunction alpha beta gamma delta zeta micro Goe Goe6983 Go-6983 Go 6983 9.212635422620
11569 GSK 1059615 New 958852-01-2 ≥98% 2012-03-15 30.959325890116 gsk-1059615 Phosphatidylinositols PI 3-kinases α PI3Ks PI3Kα PI3Ka PI3K.alpha. inhibits inhibitors inhibition thiazolidinediones cells growth human cancers ATP-competitive p110α p110.alpha. p110a E542K E545K H1047R BT474 tumors xenografts MAPKs signaling biology signals transductions 30.959325890116
13009 GSK264220A 685506-42-7 ≥98% 2009-10-21 5.281325966851 gsk264220a inhibitors endothelial lipases high-density lipoproteins cholesterol HDL-C HDL cardiovascular diseases inhibition inhibited ET 5.281325966851
13127 GW 4869 6823-69-4 ≥90% 2009-06-10 53.862989564150 gw-4869 inhibitors sphingomyelin sphingomyelinase neutral acidic TNF-α ceramides cells death GW4869 gw-4869 53.862989564150
10010556 H-89 127243-85-0 ≥98% 2008-07-08 25.158066298343 h-89 5-Isoquinolinesulfonamide; Protein Kinase Inhibitor H-89 inhibitors inhibits inhibition PKA cAMP cell signaling protein kinase S6K1 MSK1 ROCK-II ROCKII PKB.alpha. PKBalpha PKBa MAPKAP-K1b MAPKAPK1b H89 H 89 25.158066298343
10010249 H-8 (hydrochloride) 113276-94-1 ≥98% 2008-07-17 13.932707182321 h-8-hydrochloride Protein Kinase Inhibitor H-8 PKA PKG PKC MLCK cyclin C CDK8 cyclin H CDK7 p36 signal transduction inhibitor inhibits inhibition transcription 84478-11-5 13.932707182321
13312 H-9 (hydrochloride) - ≥98% 2009-07-14 12.977541436464 h-9-hydrochloride Protein Kinase Inhibitor H-9 proteins kinases inhibitors inhibits inhibitions PKCs PKAs PKGs cGMPs cAMPs signal transductions competitive potent PKA-mediated mediated phosphorylation 84468-17-7 12.977541436464
10010559 HA-1077 (hydrochloride) 203911-27-7 ≥98% 2008-09-03 53.702559852670 ha-1077-hydrochloride Eril; Fasudil; AT-877 protein kinase inhibitors inhibits inhibition ROCK-II ROCKII PRK2 MSK1 MAPKAP-K1b vasodilation hypertension diabetes renal nephropathy cancers 105628-07-7 AT877 AT 877 hydrochloride dihydrochloride monohydrochloride HCl HA1077 HA 1077 53.702559852670
13205 Halopemide Exclusive 59831-65-1 ≥98% ✓ 2009-04-21 9.318287292817 halopemide R34301; NSC 354856 inhibitors phospholipases D PLD PLD1 PLD2 dopamine receptors inhibits inhibition potent cells DP nueraleptic 9.318287292817
10995 Harmaline 304-21-2 ≥98% 2011-10-11 1.286187845304 harmaline inhibitors monoamine oxidases MAOI receptor agonists inverse agonists NMDA herbal mixtures forensics bath salts spices plants N-methyl-D-aspartate inhibits inhibition adulterant CBs cannabinoids hallucinogenic tryptamines 1.286187845304
10576 HC Toxin 83209-65-8 ≥95% 2010-11-10 24.217044198895 hc-toxin Toxin I (Helminthosporium carbonum) inhibitors histones deacetylases HDACs cancers genes regulation regulates regulators epigenetics HC-toxins cell-permable cells permable 15-lipoxygenase-1 15-LO-1 LOs lipoxygenase 15 1 tetrapeptides peptides helminthosporium carbonums cochliobolus maize pathogens Isomerases Amino Acid Acid Isomerases Amino Racemases Amino Acid Amino Acid Isomerases Acid Racemases Amino Amino Acid Racemases 24.217044198895
10011038 Hemopressin - 2009-08-13 29.761006314127 hemopressin peptides antagonist inhibitors inhibits inhibition hypertension binding asoactive vasoactive cannabinoids cbs synthetic 29.761006314127
13295 HNHA 926908-04-5 ≥98% 2009-09-03 23.011531893520 hnha Histone Deacetylase Inhibitor VI inhibitors inhibits inhibition histones deacetylase HDACs cancers fibrosarcoma HT1080 cells hyperacetylation p21 genes expressions transcription cycles arrest tumor growth murine xenograph human umbilical vein endothelial HUVECs tubes formation migration vascular endothelial factors VEGF retinal neovascularization angiogenesis 23.011531893520
10134 HQL-79 162641-16-9 ≥98% 155.543195211786 hql-79 inhibitors prostaglandins synthases PGD2 L-PGDS tetrazoles HQL79 inhibits lipocalin-type 155.543195211786
10699 HTS 01037 682741-29-3 ≥98% 2011-03-14 10.578715469613 hts-01037 adipocytes fatty acids binding proteins FABP4 AFABP A-FABP aP2 macrophages lipocytes diabetes atherosclerosis HTS-01037 HTS01037 Isomerases Amino Acid Acid Isomerases Amino Racemases Amino Acid Amino Acid Isomerases Acid Racemases Amino Amino Acid Racemases 10.578715469613
10888 HZ52 1077626-51-7 ≥98% 2011-09-30 17.110718232043 hz52 inhibitors inhibits inhibition 5-LO 5 LO 5LO leukotrienes LTBs LTB4 LTs leukocytes neutrophils inflammation shock HZ-52 HZ 52 17.110718232043
13347 IBMX 28822-58-4 ≥98% 2009-10-27 521.527108655617 ibmx NSC 165960; 1-Methyl-3-Isobutylxanthine; Isobutylmethylxanthine inhibitor cAMP cGMP phophodiesterases PDE1 PDE2 PDE3 PDE4 PDE5 PDE7 PDE11 PDE8A PDE8B PDE9 cyclic-nucleotides methylxanthines caffeine theophylline adenosine receptors antagonist SC 2964 SC-2964 SC2964 IMX NSC165960 NSC-165960 xanthine 521.527108655617
70280 (±)-Ibuprofen 15687-27-1 ≥99% 25.678516286251 -ibuprofen Motrin PPAR cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits peroxisome proliferator-activated receptors neurochemistry 25.678516286251
13624 Icariin 489-32-7 ≥97% 2010-02-11 1.115469613259 icariin PDE5 inhibitors flavonoids differentiation cancers proliferation flavonols E brevicornum horny goat weed BMP2 ED erectile dysfunction 2-Phenyl-Benzopyrans 2 Phenyl Benzopyrans 2-Phenyl-Chromenes 2 Phenyl Chromenes Bioflavonoids Flavonoids 1.115469613259
10215 IDFP 615250-02-7 ≥98% 2009-03-09 25.537969613259 idfp Isopropyl Dodecylfluorophosphonate CB1 agonist nerve agent serins organophophorus MAGL inhibitors inhibits inhibition FAAH 2-AG 2AG AEA arachidonic acids MGL inhibitors cannabinoids 25.537969613259
13323 IM-54 861891-50-1 ≥95% 2009-10-14 2.570386740331 im-54 inhibitors necrosis necrotic cells death peroxide HL-60 leukemia apoptosis PKC S6K1 protein kinases C S6 1 indolymaleimide 2.570386740331
13139 Imatinib (mesylate) 220127-57-1 ≥98% 2009-04-21 41.939928966061 imatinib-mesylate CGP57148B; Glivec; Gleevec; STI-571 inhibitors tyrosine kinase cancer chronic myelogenous leukemia CML c-ABL kits c-kit platelet-derived growth factor receptors imatinib mesilate 152459-95-5 75-75-2 gleevec 41.939928966061
13314 Indirubin-3'-monoxime 160807-49-8 ≥98% 2009-07-15 15.600626151012 indirubin-3-monoxime glycogen synthase kinase-3β GSK-3β tau proteins Alzheimer's diseases cyclin-dependent kinases CDK CDK1 cyclin A B E D1 CDK4 CDK2 CDK5 p35 growth proliferation synchronization cells arrest G2/M phases phosphorylation inhibits inhibition inhibitors 15.600626151012
70270 Indomethacin 53-86-1 ≥99% 29.233316340602 indomethacin Indocin cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin synthases synthase-1 synthase-2 PPARs peroxisome proliferator-activated receptors inhibits neurochemistry 29.233316340602
70271 Indomethacin heptyl ester - ≥98% 2.996850828729 indomethacin-heptyl-ester esters derivatives COX-2 cox2 pghs2 pghs-2 prostaglandin synthases synthase-2 inhibitors inhibits selective selectivity cyclooxygenase 2.996850828729
70273 Indomethacin N-octyl amide - ≥98% 29.865372928177 indomethacin-n-octyl-amide aromatic amides inhibitors inhibits COX-2 COX2 PGHS2 PGHS-2 prostaglandin synthases cyclooxygenases selective selectivity 29.865372928177
11572 IOX1 New 5852-78-8 ≥97% 2012-05-09 95.770095150398 iox1 hypoxia 2-oxoglutarate Fe 2OG ferrous iron-dependent oxygenases collagen histones demethylation inhibitors inhibits inhibition H3K9me3 JMJD2A JMJD2E enzymes lipids metabolism nucleic acid diseases cancers oxygenases PHF8 PHD2 FIH 95.770095150398
10617 IU1 314245-33-5 ≥98% 2011-01-31 35.355566298342 iu1 inhibitors ubiquitin proteasomes proteins degradation oxidative injury inhibited inhibition 35.355566298342
13659 IWR-1-endo 1127442-82-3 ≥98% 2010-03-23 21.186758747697 iwr-1-endo Wnt cancers embryonic developments tissues homeostasis embryogenesis tumorigenesis stem cells β-catenin genes expression transcription inhibitors inhibits inhibition proteasomes Apc Axin2 Ck1 Gsk3β IWR-1-exoendo-1,3(4)-beta-D-glucanase Endo-1,3(4)-beta-Glucanase Endo-1,3(4)-B-Glucanase beta-(1-3,1-4)glucanase 21.186758747697
13598 IWR-1-exo 1127442-87-8 ≥98% 2010-03-23 16.155635359116 iwr-1-exo Wnt cancers embryonic developments tissues homeostasis embryogenesis tumorigenesis stem cells β-catenin genes expressio Cellobiohydrolase, 1,4-beta-D-Glucan 1,4-beta-D-Glucan Cellobiohydrolase 1,4 beta D Glucan Cellobiohydrolase 1,4-beta-Cellobiosidase, Cellulose Cellulose 1,4-beta-Cellobiosidase Cellulose 1,4 beta Cellobiosidase Beta-Glucancellobiohydrolase Beta Glucancellobiohydrolase Exo-Cellobiohydrolase Exo Cellobiohydrolase Cellobiohydrolase II Cellobiohydrolase I Cellobiohydrolase A Cellobiohydrolase Exoglucanase II CEL1 Protein CbhI Proteinn transcription inhibitors inhibits inhibition controls 16.155635359116
10011246 Janex 1 202475-60-3 ≥98% 2008-12-17 0.861878453039 janex-1 WHI-P131 inhibitors inhibits inhibition JAK3 apoptosis leukemias anti-inflammatory antiinflammatory lymphocytes WHIP131 Janex 1 0.861878453039
10641 JGB1741 Exclusive 1256375-38-8 ≥98% ✓ 2011-06-20 17.811325966850 jgb1741 ILS-JGB-1741 inhibitors SIRT1 breasts cancers cells proliferation apoptosis p53 histones acetylation genes energy homeostasis regulation deacetylases sirtuins NAD+ inhibits inhibition SIRT2 SIRT3 ILS JGB 1,741 1741 SIRTs JGB-1741 JGB-1,741 17.811325966850
11232 (−)-JQ1 Exclusive New 1268524-71-5 ≥98% ✓ 2012-04-23 107.848419726214 -jq1 BET bromodomain inhibitors inhibits inhibition BRD4 BRD2 transcription cancers extra terminal domains proteins BRD3 cells inflammatory inflammation genes expression mitosis viral viruses histones chromatin JQ 1 JQ-1 (±)-JQ1 ±-JQ1 107.848419726214
11187 (+)-JQ1 Exclusive New 1268524-70-4 ≥98% ✓ 2012-04-23 220.321955079750 -jq1 BET bromodomain inhibitors inhibits inhibition BRD4 BRD2 transcription cancers JQ-1 JQ 1 extra terminal domains BRD3 cells genes expression inflammatory inflammation viral viruses mitosis histones chromatin (±)-JQ1 ±-JQ1 10741 220.321955079750
10879 JW 480 - ≥98% 2011-07-18 0.874254143646 jw-480 inhibitors lipids mediators inhibitors inhibits inhibition KIAA1363 KIAA 1363 KIAA-1363 JW480 JW-480 AADACL1 MAGE monoalkylglycerols ether neutral ether lipids NEL prostate cancers hydrolases 0.874254143646
13158 JZL 184 1101854-58-3 ≥97% 2009-01-26 215.123167587476 jzl-184 2-AG 2AG MAGL inhibitors inhibits inhibition endocannabinoids pains analgesia MGL inhibitor JZL184 JZL-184 cannabinoids 215.123167587476
13668 JZL 195 121004-12-8 ≥98% 2010-02-10 222.909116022099 jzl-195 fatty acid amide hydrolase FAAH monoacylglycerol lipase MAGL endocannabinoids arachidonoyl ethanolamide AEA 2-arachidonoylglycerol 2-AG inibitors inhibition inhibits PF-3845 PF 3845 PF3845 JZL195 JZL-195 JZL184 antinociception pain catalepsy hypomotility CB1 2AG cannabinoids inhibitors cbs sythetic Methylenedioxybenzenes 1,3-Dioxaindans 1,3 Dioxaindans 1,3-Dioxindans 1,3 Dioxindans Benzodioxoles 222.909116022099
10010239 Kenpaullone 142273-20-9 ≥98% 2007-09-04 13.485745856354 kenpaullone NSC 664704; 9-Bromopaullone GSK-3.beta. cyclin-dependent kinase cyclin CDK inhibitors inhibits inhibition proliferations cell cycle cancers 13.485745856354
10006661 Ketoprofen 22071-15-4 ≥98% 2005-05-18 13.119212991383 ketoprofen 2-(3-benzoylphenyl)propionic Acid; Oruvail; Orudis COX cyclooxygenases NSAIDS nonsteroidal non-steroidal anti-inflammatory drugs prostaglandins PGs inflammations pain racemates racemic R-enantiomers cytokines non-selective inhibits inhibitor inhibition 13.119212991383
9001148 Ketorolac New 74103-06-3 ≥98% 2012-01-12 12.447457304307 ketorolac Sprix®; Acular PF®; RS 37619; Acular LS® analgesic NSAIDs COX inhibition inhibits inhibitors ocular pain inflammation PGE2 non steroidal anti-inflammatory antiinflammatory drugs heteroaryl acetic acids derivatives cyclooxygenase opthalmalic solutions ocular COX-1 COX-2 COX1 COX2 racemic 66635-83-4 12.447457304307
70690 Ketorolac (tromethamine salt) 74103-07-4 >99% 30.135208034922 ketorolac-tromethamine-salt Toradol cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits 30.135208034922
13243 KH7 330676-02-3 ≥98% 2009-09-18 146.562790055248 kh7 sAC soluble adenylyl cyclase cAMP inhibitors inhibits inhibition cells signaling signal transduction second messenger KH 7 KH-7 signalling cyclic AMP 146.562790055248
10009437 Kifunensine 109944-15-2 ≥98% 2007-04-30 233.013867403314 kifunensine FR 900494 glycoproteins glycosidases mannosidases inhibitors kitasatosporia kifunense inhibition inhibited 233.013867403314
10505 Kinase Screening Library (96-Well) - 2010-08-09 15.102751381215 kinase-screening-library-96-well screening kinases inhibitors 15.102751381215
13318 KN-62 127191-97-3 ≥98% 2009-07-16 19.261723756906 kn-62 inhibitors calcium calmodulin-dependent kinase II CaM kinase II purinergic receptors P2RX7 P2X7 inhibition inhibited selective permeableCaMKII calcium ca modulation CaMK11CaMK2 19.261723756906
13319 KN-93 139298-40-1 ≥98% 2009-08-05 28.510515653776 kn-93 inhibitors inhibits inhibition Ca2+ calmodulin dependent Ca2+/calmodulin-dependent kinase II CaMKII histamine parietal cells cardiac myocytes 5-LO 5-lipoxygenase HIF-1a HIF-1α HIF1α colon cancers phosphorylation CAM 28.510515653776
10011011 KT 5720 108068-98-0 ≥98% 2009-01-20 131.231846882399 kt-5720 PKAs cAMPs signaling proteins kinase inhibitors inhibits inhibition phosphorylase kinase PDK1 MEK MSK1 PKα GSK3β KT5720 KT-5720 131.231846882399
10010965 KT 5823 126643-37-6 ≥95% 2009-01-15 145.532937384898 kt-5823 cGMP PKGs proteins kinases G inhibitors inhibits inhibition nitric oxides NO antibiotic KT5823 KT-5823 indolocarbazoles alkaloid PKG 145.532937384898
13627 Lansoprazole 103577-45-3 ≥98% 2010-07-19 0.937292817680 lansoprazole Prevacid; AG-1749 proton pumps inhibitors inhibits inhibition ATPases gastric acids ulcers cytochromes P450 CYP2C19 CYP3A4 Agopton Alter Cinfa Davur Lancid Lanpro Ogastro PP/K-10 154727-72-7 909251-59-8 secretion intra gastric pH increasing Sulfoxides, 2-Methylpyridine 2-Benzimidazole 2-Benzimidazole Sulfoxides, 2-Methylpyridine 2-Methylpyridine 2-Benzimidazole Sulfoxides 2 Methylpyridine 2 Benzimidazole Sulfoxides 2-Pyridinylmethylsulfinyl-2-Benzimidazoles 2 Pyridinylmethylsulfinyl 2 Benzimidazoles Sulfoxides, Benzimidazole Methylpyridine Methylpyridine Sulfoxides, Benzimidazole Benzimidazole Methylpyridine Sulfoxides 2-Pyridinylmethylsulfinylbenzimidazoles 2 Pyridinylmethylsulfinylbenzimidazoles 0.937292817680
10010631 Latrunculin B 76343-94-7 ≥97% 2009-02-20 16.449338779828 latrunculin-b monomeric actins G-actin G actins F-actin F inhibitors inhibits inhibition cytoskeleton 16.449338779828
10010329 Lavendustin C 125697-93-0 ≥98% 2008-07-08 11.503353591160 lavendustin-c HDBA; NSC 666251 EGFR kinases tyrosine pp60c-src pp60csrc CamKII SOD neutrophil activation erbstatin inhibitor inhibits inhibition Lavendustin-C 11.503353591160
16844 LED209 245342-14-7 ≥98% 2009-03-09 1.591160220994 led209 QseC virulence factors norepinephrine epinephrine pathogen AI-3 AI3 bacteria genes expression 1.591160220994
10004976 Leptomycin B 87081-35-4 >98% 2008-03-19 2.397790055249 leptomycin-b NSC 364372; Mantuamycin; LMB; Elactocin antibiotics cell cycles p53 antifungals proliferation nuclear transport inhibits inhibitors inhibition inhibiting export signals receptors NES RNA REV-response elements HIV-1 4D 3E3 2.397790055249
13810 Limaprost 74397-12-9 >98% 49.011519337017 limaprost 17α,20-dimethyl-Δ2-Prostaglandin E1; 17α,20-dimethyl-Δ2-PGE1 PGE1 analogs inhibitors platelets aggregation prostaglandins 49.011519337017
16833 Lisinopril 76547-98-3 ≥98% 2009-03-09 2.875414364640 lisinopril MK 522; MK 521 inhibitors inhibits inhibition angiotensin I II ACE endothelin 1 nitric oxide renin hypertension diabetes 2.875414364640
10010785 (±)-Lisofylline 6493-06-7 ≥98% 2009-09-18 21.729350828728 -lisofylline CT-1501R; BL 194; LSF pentoxifylline phosphatidic acids shock sepsis antiinflammatory anti-inflammatory insulin diabetes IL-12 IL-12 inhibits inhibitions inhibitors IFN-γ IFNγ β-cell cell 39476-38-5 151852-35-3 21.729350828728
80310 L-NIL (hydrochloride) 159190-45-1 ≥95% 39.362265193369 l-nil-hydrochloride selective nitric oxide synthases inhibitors inhibits iNOS inducible (2HCl) L-NIL·2HCl 39.362265193369
80320 L-NIO (hydrochloride) 36889-13-1 ≥95% 6.906003683241 l-nio-hydrochloride nitric oxide synthase inhibitors NOS NO 6.906003683241
80220 L-NNA 2149-70-4 ≥99% 11.522237569060 l-nna NG-nitro-L-Arginine; L-NG-Nitroarginine nitric oxide synthases inhibitors NOS inhibits 11.522237569060
10010338 Lovastatin 75330-75-5 ≥98% 2008-03-03 10.317160598762 lovastatin LDL-c cholesterol HMG-CoA reductase HMGCoA statins heart diseases CVD atherosclerosis HDL-c NF-kB NF-.kappa.B TNF-.alpha. apoptosis anti-cancer mevacor Altocor mevinolin inhibits inhibitors inhibition 10.317160598762
10010339 Lovastatin Hydroxy Acid (sodium salt) Exclusive - >98% ✓ 2008-03-04 12.599079189686 lovastatin-hydroxy-acid-sodium-salt atherosclerosis LDL cholesterol HMG-CoA reductase statin heart disease CVD LDL-c HDL HDL-c inhibitors inhibits inhibition 12.599079189686
81650 L-Sepiapterin 17094-01-8 >99% 7.683425414365 l-sepiapterin tetrahydrobiopterin pterin GTP cyclohydrolase inhibitors 7.683425414365
10010541 L-threo-Sphingosine C-18 25695-95-8 >98% 2008-01-22 21.623130755064 l-threo-sphingosine-c-18 D-erythro-sphingosine sphingolipids ceramides serines palmitoyltransferases protein kinases C cells proliferations cytoskeletal organization inhibitor inhibition inhibits PKCsSPTs 21.623130755064
11215 Lupeol New 545-47-1 ≥98% 2012-02-15 22.361170100521 lupeol NSC 90487; Monogynol B; Fagarasterol; β-Viscol; Lupenol; Clerodol AC-1371 AC1371 AC 1371 132473-92-8 200123-55-3 fagarsterol dietary triterpenes anti-inflammatory anticarcinogenic antimutagenic antimaralia fruits vegetables medicinal plants antimalarial cells carcinoma cancers SMMC7721 SMMC-7721 SMMC 7721 HepG2 melanoma mel928 mel-928 mel 928 mel1241 mel-1241 mel 1241 blood pressure strokes hypertension rats genes cholesterol synthesis neutrophils monogynol B NSC-90487 NSC90487 beta-viscol b-viscol 22.361170100521
10004161 Luteolin 491-70-3 >98% 2004-04-20 28.349535911602 luteolin lignans flavones flavanoids metalloproteinases plants polyphenolic perilla leaves soybeans inhibitors inhibits inhibition reticulocytes 15-LOs 15-LOX 15-lipoxygenases TNFalpha TNF.alpha. TNF-alpha TNF-.alpha. 28.349535911602
70920 LY294002 154447-36-6 >98% 71.766895436873 ly294002 phosphatidylinositols PI3-kinase inhibitors inhibits PI3K inhibition ly 294002 71.766895436873
13341 LY364947 396129-53-6 ≥98% 2009-07-23 57.630497237569 ly364947 TGF-β RI Kinase Inhibitor; HTS 466284 TGF-β receptor inhibitors antagonists Smad p38 MAPK MLK-7 cells growth fibroblasts NIH 3T3 cells phosphorylation fibronectin PAI-1 uPA matrigel invasion MDA-MB-231 cells transforming factors LY 364947 LY-364947 HTS-466284 HTS466284 HTS 466284 ALK5 Inhibitor I TβR-I inhibitor Transforming Growth Factor-β Type I Receptor Kinase Inhbitor [3-(Pyridin-2-yl)-4-(4-quinoynyl)]-1H-pyrazole 57.630497237569
13174 M 344 251456-60-7 ≥98% 2009-07-24 25.973145718231 m-344 D237; Histone Deacetylase Inhibitor III; MS 344 HDACs inhibitors inhibits inhibitions histones deacetylases HDAC1 HDAC6 cancers squamous carcinoma radiation cells cycles arrest apoptosis endometrial ovarian M344 MS344 M-344 MS-344 25.973145718231
10010497 Manumycin A 52665-74-4 ≥98% 2008-06-25 16.571464088398 manumycin-a UCF 1C; NSC 622141 farnesyltransferase inhibitors inhibits inhibition cancer antitumor anti-tumor signal transduction Ras farnesylation NF-.kappa.B NF-kB NF-kappaB 16.571464088398
10009645 Maslinic Acid Exclusive 4373-41-5 >98% ✓ 2007-11-02 16.165856353591 maslinic-acid 2α-Hydroxyoleanoic Acid; Crategolic Acid cancer apoptosis antiproliferative antioxidant HIV inhibition inhibitor inhibits leukemia cells astrocytoma CaCo-2 colon HIV-1 aids 16.165856353591
70550 Meclofenamate (sodium salt) 6385-02-0 >99% 5.985428176795 meclofenamate-sodium-salt PPAR cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits peroxisome proliferator-activated receptors 5.985428176795
81020 MEG (sulfate) 3979-00-8 >98% 46.952143646409 meg-sulfate iNOS inducible nitric oxide synthases inhibitors peroxynitrite scavenger selective 2-mercaptoethyl-guanidine 46.952143646409
10624 Methylenedioxy Pyrovalerone Exclusive 687603-66-3 ≥98% ✓ 2011-01-07 31.370797503581 methylenedioxy-pyrovalerone MDPV 3,4-methylenedioxypyrovalerone inhibitors neurotransmitters dopamine norepinephrine MDMA ecstasy forensics designer drugs Hemihydrate Apomorphine Hydrochloride Anhydrous Apomorphine Hydrochloride Chloride Apomorphine Apomorphin Teclapharm Apomorphine Chloride Berberine Alkaloids Camptothecine Camptothecin Umbellatine Apomorphine Britaject Berberine Alkaloids Berbines Apokinon 31.370797503581
10679 Methylenedioxy Pyrovalerone-d8 (hydrochloride) 1246820-09-6 ≥99% deuterated product 2011-02-15 24.109879362481 methylenedioxy-pyrovalerone-d8-hydrochloride MDPV-d8 3,4-methylenedioxypyrovalerone inhibitors neurotransmitters dopamine norepinephrine MDMA ecstasy neuroscience forensics designer drugs deuterateds deuteriums GC/MS GC-MS LC/MS LC-MS mass spectrometry MS standards 24.109879362481
10684 Methylenedioxy Pyrovalerone (hydrochloride) 24622-62-6 ≥98% 2011-01-07 42.836000070156 methylenedioxy-pyrovalerone-hydrochloride MDPV 3,4-methylenedioxypyrovalerone inhibitors neurotransmitters dopamine norepinephrine MDMA ecstasy neuroscience forensics designer drugs 42.836000070156
10010252 Methyl-L-NIO (hydrochloride) 150403-96-6 >98% 2008-02-12 15.730469613259 methyl-l-nio-hydrochloride NOS L-arginine NO nitric oxide nNOS eNOS iNOS inhibitor inhibits inhibition vasodilation inflammation 15.730469613259
10010340 Mevastatin 73573-88-3 ≥98% 2008-07-16 10.329502762430 mevastatin Statin I; NSC 281245; L 637312; Compactin; ML 236B; CS 500 atherosclerosis cholesterol HMG-CoA reductases statins heart diseases CVD LDL-c LDLc HDL-c HDLc TNF-.alpha. TNF-a TNF-alpha NF-kb NF-.kappa.B NF-kappaB apoptosis cancers cardiovascular TNF.alpha. inhibtis inhibitor inhibition HMGCoA pythium ultimum 10.329502762430
13357 Milrinone 78415-72-2 ≥98% 2011-03-07 310.264618784530 milrinone Primacor®; WIN 47203 inhibitors phosphodiesterases PDE3A PDE3B cAMP vascular diseases cardiovascular effects Sanofi Synthelabo Brand of Milrinone Lactate Sanofi Winthrop Brand of Milrinone Lactate Sanofi Synthelabo Brand of Milrinone Sanofi Brand of Milrinone Lactate Lactate Milrinone Milrinone Lactate Win-47203 Win 47203 Milrinone Corotrope Win47203 Primacor Corotrop inhibits inhibition 310.264618784530
13208 Mirin 299953-00-7 ≥95% 2009-04-15 42.463867403315 mirin DNA damage ATM histone nuclease MRN Mre11 Rad50 Nbs1 repair 42.463867403315
11434 Mithramycin A New 18378-89-7 ≥98% 2012-05-01 73.940322283609 mithramycin-a A 2371; Antibiotic LA 7017; PA 144; NSC 24559; Plicamycin; Aureolic Acid 1395-17-1 1403-98-1 12708-66-6 12708-67-7 23973-19-5 97666-60-9 219612-19-8 744999-90-4 807260-73-7 826336-23-6 899900-19-7 1195235-16-5 mithracin NSC-24559 NSC24559 PA144 PA-144 A2371 A-2371 plicatomycin anti-tumors neuroprotective antibiotics chemotherapeutics histones acetylation transcription factors chromatin regulation Sp1 inhibitors inhibits inhibition oncogene TRAIL cancers Streptomyces grieseus S. grieseus DNA apoptosis 73.940322283609
10133 MK 886 (sodium salt) 118427-55-7 >99% 2004-06-11 73.361924493554 mk-886-sodium-salt guanylate cyclases inhibitors leukotrienes FLAP 5-LOs 5-LOX 5-lipoxygenases activating proteins inhibits inhibition mk886 mk-886 73.361924493554
10010236 ML-9 105637-50-1 ≥98% 2008-01-21 13.940220994475 ml-9 PKB Akt inhibitors inhibits inhibition serine/threonine kinase PKA P90S6 MAP kinases cancers anti-cancers insulin glucose transports calcium channels calmodulin intracellular smooth muscles asthma 13.940220994475
13284 MS-275 209783-80-2 ≥98% 2009-11-05 37.997177716390 ms-275 Entinostat; SNDX 275 inhibitors histone deacetylases HDACs HDAC1 HDAC3 HDAC8 cyclin-dependent kinase inhibitor 1A p21 CIP1 WAF1 cell growth differentiation tumors cancers apoptosis adriamycin PARP Hsp90 ms275 MS 27-275 SNDX-275 SNDX275 MS27275 37.997177716390
75770 MS-PPOH 206052-02-0 ≥98% 2007-02-23 32.007127071823 ms-ppoh CYP450 cytochromes epoxidase activity inhibitor inhibition inhibits microsomal enzymes endocrinology 32.007127071823
63150 Myriocin 35891-70-4 >98% 2007-05-03 56.576548719507 myriocin Thermozymocidin; ISP-1 serine palmitoyltransferase inhibitors sphingolipids antibiotic immunosuppressants inhibition inhibited atherosclerosis 56.576548719507
70272 N-(2-phenylethyl)-Indomethacin amide - ≥98% 17.112367797948 n-2-phenylethyl-indomethacin-amide N-2PIA aromatic amides inhibitors inhibits COX-2 COX2 PGHS2 PGHS-2 prostaglandin H synthases cyclooxygenases 17.112367797948
70274 N-(3-pyridyl)-Indomethacin amide - ≥98% 17.321917916338 n-3-pyridyl-indomethacin-amide N-3PyIA aromatic amides inhibitors inhibits COX-2 COX2 PGHS2 PGHS-2 prostaglandin H synthases cyclooxygenases COX-1 COX1 PGHS1 PGHS 1 17.321917916338
70278 N-(4-acetamidophenyl)-Indomethacin amide - ≥98% 19.964429097606 n-4-acetamidophenyl-indomethacin-amide N-4AIA aromatic amides inhibitors inhibits COX-2 COX2 PGHS2 PGHS-2 prostaglandin H synthases cyclooxygenases 19.964429097606
10017 N-Ac-Asp-Glu-Val-Asp-CHO 184179-08-6 >98% 2004-04-29 15.539779005524 n-ac-asp-glu-val-asp-cho Ac-DEVD-CHO Valinamide caspases caspase 3 inhibitors Yama ICE3 CPP32 Apopain inhibition inhibits selective apoptosis 15.539779005524
10008284 N-acetyl-2-carboxy Benzenesulfonamide Exclusive 849067-18-1 ≥98% ✓ 2006-05-10 15.836408839779 n-acetyl-2-carboxy-benzenesulfonamide analogs aspirin inhibits inhibitors inhibition cyclooxygenaes COX-1 COX-2 COX1 COX2 15.836408839779
10016 N-Ac-Tyr-Val-Ala-Asp-CHO 143313-51-3 >98% 2004-04-14 28.992734806629 n-ac-tyr-val-ala-asp-cho Ac-YVAD-CHO inhibitor inhibits apoptosis interleukins inhibition selective irreversible interleukin-1.beta.converting enzyme ICE Caspase-1-IL-1.beta. Il1beta neuroprotective cerebral ischemia alaninamides 28.992734806629
13055 Naphthofluorescein 61419-02-1 ≥98% 2009-03-20 1.601988950276 naphthofluorescein CCG 8295 furin matrix metalloproteinase MTA-MMP MMP2 motility invasion cancer metastasis MMP inhibitors naphthafluorescein 1.601988950276
13570 N-Benzylacetamidine (hydrobromide) 186545-76-6 ≥98% 2010-02-11 34.912016574585 n-benzylacetamidine-hydrobromide NO nitric oxide synthases NOS iNOS inflammation immune responses eNOS inhibitors inhibits inhibition inflammatory alpha-D-N-Acetyl-Galactosaminyloligosaccharidase alpha D N Acetyl Galactosaminyloligosaccharidase alpha-D-N-Acetylgalactosaminyloligosaccharidase alpha D N Acetylgalactosaminyloligosaccharidase endo-N-Acetyl-alpha-D-Galactosamidase endo N Acetyl alpha D Galactosamidase endo-alpha-N-Acetylgalactosaminidase endo alpha N Acetylgalactosaminidase N-Acetyl-alpha-D-Galactosaminidase N Acetyl alpha D Galactosaminidase alpha-N-Acetyl-D-galactosaminidase alpha N Acetyl D galactosaminidase alpha-N-Acetylgalactosaminidase alpha N Acetylgalactosaminidase alpha-Galactosidase B alpha Galactosidase B 34.912016574585
10527 Necrostatin-5 New 337349-54-9 ≥98% 2012-04-02 41.759259259259 necrostatin-5 Nec-5 necroptosis necrosis cells death RIP1 TNFα RIP1 kinases inhibitors inhibits inhibition necrostatin 5 caspase Fas ligands serine threonine receptors tumors TNFα TNF-α FADD jurkat serine/threonine Ser/Thr 41.759259259259
10528 Necrostatin-7 New 351062-08-3 ≥98% 2012-03-13 21.105105105105 necrostatin-7 Nec-7 necroptosis necrosis cells death TNFα TNF-α inhibitors inhibits inhibition RIP1 Fas ligands tumors kinases Nec7 Nec 7 21.105105105105
10584 (−)-Neplanocin A Exclusive 72877-50-0 ≥98% ✓ 2011-03-25 62.464135753748 -neplanocin-a S-adenosylhomocysteines hydrolases SAH inhibitors S-adenosylmethionines SAM methyltransferases antitumor antiviral cancer virus methylation Neplanocin A neplanocinA anti-tumor 62.464135753748
10554 NG-amino-L-Arginine (hydrochloride) - ≥97% 2010-09-16 6.794726268207 ng-amino-l-arginine-hydrochloride 57444-72-1 inhibitors inhibits inhibition nNOS iNOS eNOS nitric oxides synthesis BR labs BogaR 6.794726268207
10011250 NH125 278603-08-0 ≥95% 2008-11-21 7.912790055249 nh125 antibacterial histidine kinase cancer cell cycle eEF-2K drug resistance imidazoles 7.912790055249
10649 Niclosamide 50-65-7 ≥95% 2011-01-12 3.086436464088 niclosamide antihelminthic helminth tapeworms inhibitors STAT3 cancers proliferation anti-helminthic salicylanilide Du 145 DU145 DU-145 Niclosamide, 2-Aminoethanol (1:1) Aventis Brand of Niclosamide Bayer Brand of Niclosamide Clonitralide Niclosamide Bayluscide Bayer 2353 Trédémine Niclocide Radewerm Phenasal Bayer 73 Yomesan Fenasal 3.086436464088
70650 Niflumic Acid 4394-00-7 >99% 57.738666140489 niflumic-acid UP83; Nifluril; Donalgin; Actol selective inhibitors COX-2 PGHS-2 prostaglandins H Synthase 2 acids cyclooxygenase 57.738666140489
10010422 Nilotinib 641571-10-0 ≥98% 2009-10-23 24.972909760589 nilotinib AMN107 tyrosine kinases inhibitors therapy cancer Bcr/Abl chronic myeloid leukemia MLL philadelphia chromosomes acute lymphoblastic ALL imatinib gleevec genes expression DNA helicase complex cyclins cyclin-dependent cells proliferation 24.972909760589
70640 Nimesulide 51803-78-2 >99% 63.513878453038 nimesulide R805 selective inhibitors COX-2 PGHS-2 synthases prostaglandins R-805 cyclooxygenases inhibits 63.513878453038
13692 Nitazoxanide 55981-09-4 ≥95% 2010-08-11 4.592744014733 nitazoxanide NTZ; NSC 697855 antiparasitics Giardia Cryptosporidium tuberculosis inhibitors inhibits inhibition PH 6776 alinia BRN 1225475 cryptaz NTZ anti-parasitics Thiazoles 4.592744014733
10004971 N,N'-Dicyclohexylurea 2387-23-7 ≥98% 2010-03-17 22.350718232044 n-n-dicyclohexylurea DCU; NSC 17013 hypertension Epoxyeicosatrienoic acids EETs soluble epoxide hydrolase sEH inhibitors inhibits inhibiting PPARα 1,3-dicyclohexylurea dicyclohexylcarbodiamide Doms-Adrian Brand of Alanine Doms Adrian Brand of Alanine Alanine Doms-Adrian Brand Alanine, L-Isomer Alanine, L Isomer L-Isomer Alanine L-Alanine L Alanine Alanine Abufène 22.350718232044
11040 Nodinitib-1 New 799264-47-4 ≥95% 2012-01-20 11.548480010440 nodinitib-1 ML130; CID-1088438 NOD1 NLR innate immunity NF-κB signaling inflammation MAPK inflammatory diseases inhibitors inhibition inhibits NACHT leucine proteins bacterial bacteria ligands stress kinases interferons polymorphisms genes asthma bowel multiple sclerosis MS cells CD83 CD86 HLA-DR IL-1β IL-6 TNFα 11.548480010440
10005705 NO-Indomethacin Exclusive 301838-28-8 >98% ✓ 2004-10-20 5.517237569061 no-indomethacin NCX 2121 inhibition inhibitors NSAIDs non-steroidal anti-inflammatory drugs inhibits nitric oxides cancer chemopreventative donor gastrointestinal NOs PaCa-2 PaCa2 pancreatic analgesic 5.517237569061
10115 N-Oleoyl Dopamine 105955-11-1 ≥98% 5.504001578531 n-oleoyl-dopamine ODA VR1 agonists CB1 receptors analogs vanilloids cannabinoids analgesic amides N-oleoyldopamine inhibits inhibitors inhibition 5-lipoxygenases 5-LOs binding selective FAAH hydrolases fatty acid neurochemistry neuroscience cbs synthetic 5.504001578531
70300 Nordihydroguaiaretic Acid 500-38-9 ≥95% 24.473197513811 nordihydroguaiaretic-acid NDGA lipoxygenases inhibitors inhibits NDGA cyclooxygenase 24.473197513811
10006861 nor-NOHA 189302-40-7 ≥97% 2007-07-13 31.080327761848 nor-noha Nω-hydroxy-nor-Arginine spibio spi-bio buffers rat liver inhibitor inhibitors murine macrophags cells nitric oxides arginases 31.080327761848
81600 NS-2028 204326-43-2 >99% 21.619309392265 ns-2028 specificity inhibitors guanylyl cyclase NS2028 guanylate cyclic cGMP inhibits 21.619309392265
70590 NS-398 123653-11-2 >98% 140.299861878453 ns-398 cyclooxygenases inhibitors NSAIDs COX-2 nonsteroidal anti-inflammatory drugs cox2 pghs2 pghs-2 prostaglandins synthases synthase-2 inhibits selective ns398 selectivity neurochemistry 140.299861878453
10011255 NSC 210902 51726-83-1 ≥95% 2008-09-15 3.973812154697 nsc-210902 Inhibitor inhibits inhibition CK2 kinase cell signaling apoptosis cancers NSC210902 3.973812154697
13196 NSC 23766 (hydrochloride) 1177865-17-6 ≥98% 2010-07-20 18.908674033149 nsc-23766-hydrochloride 733767-34-5 GTPases cells cycles growth proliferations cell-cell adhesions motility differentiation guanine nucleotides exchange factors GEFs inhibitors inhibits inhibition cell migration Aminoquinolines angiogenesis leukemia cancers gene expression Rac1 Inhibitor 18.908674033149
13303 NSC 663284 383907-43-5 ≥98% 2010-04-01 14.270745856353 nsc-663284 Cdc25 Phosphatase Inhibitor II; DA-3003-1 dual specificity phosphatases CDC25 Cdc25A Cdc25B Cdc25C proto-oncogenes cancers inhibitors VHR PTP1B MKP-1 Cdk1 Cdk2 cells proliferation tumors inhibits inhibition Cdcs potent cell-permeable irreversible 14.270745856353
13308 NU 7026 154447-35-5 ≥95% 2009-09-21 33.540027624309 nu-7026 DNA-PK Inhibitor II; LY293646 DNA-dependent proteins kinase DNA-PK strand breaks ionizing radiation DNA repair inhibitors inhibitis inhibitions PI3K ATM ATR PAPR-1 PARP1 cytotoxicity topoisomerase II leukemia mitoxantrone NU-7026 NU 7026 ataxia telangiectasia mutated Rad3 related Rad3-related Rad 3 Rad-3 DNA-Dependent Protein Kinase 33.540027624309
18585 (−)-Nutlin-3 - ≥98% 2008-08-06 347.018968692449 -nutlin-3 Nutlin 3a P53 cellular stress proliferation cells cycle apoptosis tumor suppressor MDM2 agents Nutlin-3 enantiomer a 347.018968692449
10009816 (+)-Nutlin-3 - ≥98% 2008-08-11 130.763991712707 -nutlin-3 Nutlin 3b p53 cellular stress proliferation cells cycle apoptosis tumer suppressor MDM2 inactive inhibitors inhibits inhibition Nutlin-3 enantiomer b 130.763991712707
13641 NVP-AEW541 (hydrochloride) - ≥98% 2010-07-28 41.979834254143 nvp-aew541-hydrochloride 475488-34-7 IGF-1R Insulin-like growth factor I receptors tyrosine kinases angiogenesis cells proliferation cancers inhibitors inhibition inhibits 701294-63-5 Ins-R NWT-21 Pyrroles 41.979834254143
10565 NVP-BEZ235 915019-65-7 ≥98% 2010-10-12 48.377927007512 nvp-bez235 phosphatidylinositols 3-kinases PI3Ks Akt/PKB mTORs cancers inhibitors inhibits inhibition angiogenesis genes expressions apoptosis differentiation rapamycin phosphatidyls inositols phosphatidylinositols-3-kinase Imidazoles BEZ235 48.377927007512
70263 O-Acetyl Salicylhydroxamic Acid - >98% 26.774475138121 o-acetyl-salicylhydroxamic-acid O-ASHA; AcSHA cyclooxygenases inhibitors COX-1 COX-2 cox1 cox2 pghs1 pghs-1 pghs-2 prostaglandin synthases inhibits nonselective irreversible pghs2 26.774475138121
10010547 O-Arachidonoyl Glycidol Exclusive 439146-24-4 >98% ✓ 2008-03-31 19.853933701658 o-arachidonoyl-glycidol 2-AG 2-arachidonoyl glycerol 2-oleoylglycerol N-arachidonoylethanolamine anandamide AEA FAAH endocannabinoid obesity pain neurodegenerative diseases monoacylglycerol lipase inhibits inhibitors inhibitions MAGL MGL cannabinoids 19.853933701658
81410 ODQ 41443-28-1 >98% 21.055049723756 odq soluble guanylyl cyclase inhibitors guanylate cyclase NO nitric oxide sGC hypoxia 21.055049723756
10010299 Oleoyl 3-carbacyclic Phosphatidic Acid Exclusive - ≥95% ✓ 2009-10-14 15.632520718232 oleoyl-3-carbacyclic-phosphatidic-acid 3-ccPA 18:1 cyclic phosphatidic acids cPAs lysophosphatidic LPA ccPA 3ccPA oleate transcellular migration MM1 cells mesothelial autotoxin cancer survival growth migration invasion metastasis antagonist LPA1 LPA2 LPA3 476310-24-4 15.632520718232
9000629 Oleoyl Serotonin Exclusive 1002100-44-8 ≥98% ✓ 2010-05-18 6.570323599053 oleoyl-serotonin N-arachidonoyl serotonin AA-5-HT AA-5HT antagonists fatty acids amide hydrolase FAAH transient receptors potential vanilloid-type 1 channels TRPV1 pain capsaicin ethanolamine anandamide AEA Hydrolase Long-Chain Fatty-Acyl-CoA Fatty-Acyl-CoA Hydrolase Long-Chain Long-Chain Fatty-Acyl-CoA Hydrolase Long Chain Fatty Acyl CoA Hydrolase Palmitoyl Coenzyme A Hydrolase Acylhydrolase Oleoyl-CoA Thioesterase Fatty Acyl Oleoyl-CoA Acylhydrolase Oleoyl CoA Acylhydrolase Hydrolase Palmitoyl-CoA Deacylase, Palmitoyl CoA CoA Deacylase, Palmitoyl Thioesterase, Palmitoyl Palmitoyl-CoA Hydrolase Palmitoyl CoA Hydrolase Palmitoyl CoA Deacylase Hydrolase Stearoyl CoA Fatty Acyl Thioesterase CoA Hydrolase Stearoyl Stearoyl CoA Hydrolase Palmitoyl Thioesterase Hydrolase Acyl CoA CoA Hydrolase Acyl Acyl CoA Hydrolase Thioesterase I 6.570323599053
9000694 Oleoyl Serotonin-d17 Exclusive - ≥99% deuterated forms (d1-d17) ✓ 2010-09-27 6.470165745857 oleoyl-serotonin-d17 N-arachidonoyl serotonin AA-5-HT AA-5HT antagonists fatty acids amide hydrolase FAAH transient receptors potential vanilloid-type 1 channels TRPV1 pain capsaicin ethanolamine anandamide AEA deuterateds deuteriums MS mass spectrometry GC-MS LC-MS GC/MS LC/MS standards 6.470165745857
70560 Oleyloxyethyl Phosphorylcholine 84601-19-4 ≥98% 19.847928176795 oleyloxyethyl-phosphorylcholine phospholipase inhibitors 19.847928176795
11342 Oligomycin A New 579-13-5 ≥98% 2012-03-05 15.926646341463 oligomycin-a MCH 32 11030-76-5 21307-25-5 31422-20-5 macrolide isomers mitochondria F1F0-ATP synthases apoptosis antifungals antitumors nematocidal Streptomyces toxic metabolism analogs MCH-32 MCH32 15.926646341463
11343 Oligomycin B New 11050-94-5 ≥98% 2012-03-05 15.700853658536 oligomycin-b macrolide isomers mitochondria inhibitors ATP synthase inhibits inhibitions toxic mitochondrial metabolism myocardial ischemia Streptomyces toxic calcium rats neurons 15.700853658536
10010240 Olomoucine 101622-51-9 ≥98% 2007-09-13 11.101562746645 olomoucine inhibitors inhibits inhibition cyclin-dependent kinases cdks spinal cord injury SCI G1 cell cycle 11.101562746645
10005426 Orlistat 96829-58-2 ≥98% 2010-03-30 31.445813382443 orlistat Xenical™; Tetrahydrolipstatin; Alli DAGL 2-AG obesity gastric pancreatic lipases carboxyl esters inhibitors GIP 111397-16-1 GLP-1 anti-obesity antiobesity CCK PP inhibition inhibited GLP 1 GLP1 diacylglycerol Leucine, L-Isomer Leucine L Isomer L-Isomer Leucine L-Leucine Leucine 31.445813382443
13804 OU749 519170-13-9 ≥95% 2010-07-20 1.254530386740 ou749 γ-Glutamyl transferases γ-glutamyl transpeptidases glutathione markers liver dysfunction alcohol abuses biomarkers diabetes cardiovascular diseases cancers acivicin OU-749 OU 749 Mixtures Sulfonamide Sulfonamide Mixtures Sulfonamides 1.254530386740
13521 Oxalomalic Acid (sodium salt) 89304-26-7 ≥95% 2010-02-05 52.536767955800 oxalomalic-acid-sodium-salt aconitases citric acids glutamate oxidative injuries inhibitors inhibition inhibits oxalomalics oxaloacetate glyoxylate iron regulatory proteins IRP Oxalate Monohydrogen Monopotassium Monohydrogen Monopotassium Oxalate oxalates 52.536767955800
13176 Oxamflatin 151720-43-3 ≥95% 2010-11-16 28.367523020257 oxamflatin Metacept 3 HDACs histones deacetylases genes expressions morphology motility apoptosis cells cycles cancers reducing reduction proliferation Acids Hydroxamic Hydroxamic Acids Acid Hydroxamic Hydroxamic Acid 28.367523020257
70515 Ozagrel 82571-53-7 ≥98% 3.360220994475 ozagrel OKY-046 thromboxanes synthases inhibitors inhibits imidizoles TXAs antihypertensive inhibition atherosclerosis 3.360220994475
10010298 Palmitoleoyl 3-carbacyclic Phosphatidic Acid Exclusive 910228-13-6 ≥95% ✓ 2009-11-03 11.081066723331 palmitoleoyl-3-carbacyclic-phosphatidic-acid 3-carbacyclic PA; 3-ccPA 16:1 cyclic phosphatidic acids cPAs lysophosphatidic LPA ccPA 3ccPA palmitoleate transcellular migration MM1 cells mesothelial autotoxins cancer survival growth migration invasion metastasis NPP2 ENPP2 ectonucleotide pyro phosphatase/phosphodiesterase 2 11.081066723331
10010293 Palmitoyl 3-carbacyclic Phosphatidic Acid Exclusive 476310-22-2 ≥95% ✓ 2009-10-07 15.241019588146 palmitoyl-3-carbacyclic-phosphatidic-acid 3-ccPA 16:0 cyclic acids cPAs lysophosphatidic LPA ccPA 3ccPA palmitate transcellular migration MM1 cells mesothelial autotoxins cancers survival growth migration invasion metastasis 15.241019588146
9000630 Palmitoyl Serotonin Exclusive 212707-51-2 ≥98% ✓ 2010-05-18 7.061310181531 palmitoyl-serotonin N-arachidonoyl serotonin AA-5-HT AA-5HT antagonists fatty acids amide hydrolase FAAH transient receptors potential vanilloid-type 1 channels TRPV1 pain capsaicin ethanolamine anandamide AEA Hydrolase Long-Chain Fatty-Acyl-CoA Fatty-Acyl-CoA Hydrolase Long-Chain Long-Chain Fatty-Acyl-CoA Hydrolase Long Chain Fatty Acyl CoA Hydrolase Palmitoyl Coenzyme A Hydrolase Acylhydrolase Oleoyl-CoA Thioesterase Fatty Acyl Oleoyl-CoA Acylhydrolase Oleoyl CoA Acylhydrolase Hydrolase Palmitoyl-CoA Deacylase Palmitoyl CoA CoA Deacylase Palmitoyl Thioesterase Palmitoyl Palmitoyl-CoA Hydrolase Palmitoyl CoA Hydrolase Palmitoyl CoA Deacylase Hydrolase Stearoyl CoA Fatty Acyl Thioesterase CoA Hydrolase Stearoyl Stearoyl CoA Hydrolase Palmitoyl Thioesterase Hydrolase Acyl CoA CoA Hydrolase Acyl Acyl CoA Hydrolase Thioesterase I 7.061310181531
10011133 Papaverine 58-74-2 ≥98% 2009-02-09 4.123057090239 papaverine NSC 136630 phosphodiesterase cAMPs vasospasm erectile dysfunction inhibitors inhibits inhibition papervin 4.123057090239
11345 Paxilline New 57186-25-1 ≥98% 2012-03-01 10.565642497180 paxilline (+)-Paxilline Paxicillin Paxillin inhibitors inhibits inhibitions channels K+ blockers potassium BKCa cells signaling smooth muscle vascular cardiovascular neuronal neuroscience 10.565642497180
13034 PD 0325901 391210-10-9 ≥98% 2009-03-13 45.531495720653 pd-0325901 MEK ERK RAS RAF MAPK tumors stem cells cancers differentiation signaling GSK3 kinase inhibitors inhibits inhibition pd325901 pd 325901 PD0325901 45.531495720653
10010518 PD 146176 4079-26-9 ≥98% 2009-02-25 18.308729669749 pd-146176 NSC 168807 atherosclerosis 15-LOs 15-lipoxygenases oxidant injury injuries apoptosis amyloid β proteins inhibitors inhibits inhibitions Alzheimers disease oxidative stress pd146176 18.308729669749
9000988 PD 166326 New 185039-91-2 ≥98% 2011-11-30 13.817691869969 pd-166326 inhibitors cancers c-abl c-src Bcl/Abl tyrosine receptors kinases cells signaling leukemia CML chronic myelogenous leukemia PD-166326 PD166326 pyridopyrimidine STI571 mesylate 13.817691869969
10006727 PD 169316 152121-53-4 >98% 2006-04-12 12.142879411785 pd-169316 p38 mitogen-activated proteins kinases MAPK enzymes signal transductions inhibitors inhibits A C.alpha. apoptosis neuronal cells trophic factors potassium nerves growth pd169316 pd-169316 12.142879411785
13032 PD 173074 219580-11-7 ≥98% 2009-07-29 48.426305915947 pd-173074 fibroblast growths factors receptors FGFRs FGFR1 tyrosine kinase activity activities activation signals propagation inhibitors inhibition inhibits autophosphorylation PDGFR c-Src cSrc c Src EGFR InsR MEK PKC FGFR2 FGFR3 FGFR4 FGFR5 angiogenesis cancers tumors self-renewal self renewal stems cells ERK1/2 ERK-1/2 ERK 1/2 48.426305915947
10012431 PD 184161 Exclusive 212631-67-9 ≥98% ✓ 2009-06-09 12.113645758542 pd-184161 MEK inhibitors MAP kinase ERK signaling cancer MEK 1/2 inhibition inhibited ERK 1/2 potent selective pd184161 12.113645758542
10006726 PD 98059 167869-21-8 >98% 2005-09-12 17.671676392078 pd-98059 potent selective MAPK mitogen-activated proteins kinases family serines threonines cellular PD-98059 programs cells proliferation differentiation movement death noncompetitive inhibits inhibitors inhibition pathways activation MAPKK1 Raf MEK MAPKK2 MAPKK-1 PD98059 MAPKK-2 ERK 17.671676392078
11440 Penicillic Acid New 90-65-3 ≥98% 2012-04-18 124.444444444445 penicillic-acid NSC 402844 NSC402844 NSC-402844 quorum sensing virulence mycotoxins inhibitors inhibits inhibition bacterial infection Fas apoptosis caspase-8 Burkitt’s lymphoma Penicillium mold corn grains acids Pseudomonas aeruginosa raji genes 124.444444444445
13279 PF-3845 1196109-52-0 ≥98% 2010-01-27 43.794327808471 pf-3845 fatty acids hydrolase FAAH N-acyl ethanolamines NAEs endocannabinoids N-arachidonoyl ethanolamine anandamide AEA inhibitors inhibits inflammation pain PF3845 PF 3845 cannabinoids cbs synthetic Antibodies Monoclonal Monoclonal Antibodies 43.794327808471
10010908 PF-750 959151-50-9 >98% 2008-03-25 11.054506215470 pf-750 FAAH inhibitors inhibits inhibition cannabinoids depression anxiety inflammation pain neurochemistry 11.054506215470
70400 Phenylbutazone 50-33-9 >99% 9.224254143646 phenylbutazone cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits PGIS 9.224254143646
11576 Phlorizin New 60-81-1 ≥98% 2012-05-01 153.727862912891 phlorizin NSC 2833; Floridzin Phloretin 2'-O-glucoside 2'-O-β-D-glucopyranoside 2'-glucoside 2'-β-D-Glucoside Phlorhizin Phloridzin Phloridzosid Phlorizine Phlorizoside Phlorrhizin 16055-86-0 52276-56-9 112318-65-7 sodium Na+ glucose co-transporters cotransporters transport 1 2 SGLT1 SGLT2 small intestines intestinal kidneys nephrons glomerulus Bowman's capsules reabsorption blood streams inhibition inhibits inhibitors plasma levels diabetes treatments diabetic apple trees bark blocks blocking renal absorption α-methyl-D-glucopyranoside α-MDG uptake humans COS-1 cells expressing expression hSGLT1 hSGLT2 competitive glucosuria resorption Na+/D-glucose 153.727862912891
10735 Phthalazinone pyrazole Exclusive 880487-62-7 ≥98% ✓ 2011-07-27 5.267071823204 phthalazinone-pyrazole inhibitors inhibits inhibition auroras kinases cells cycle cancers centrosomes mitosis spindles cancers proliferation cells growth phosphorylation Auroroa-A Aurora-B Aurora-C A B C HCT116 HCT-116 Colo 116 HCT 116 Colo116 Colo-116 MCF7 MCF-7 MCF 7 5.267071823204
10009209 PI-103 371935-74-9 ≥98% 2007-01-19 22.568281495123 pi-103 phosphoinositides PI3-kinases Phosphatidylinositols cancers Glioma DNA-PK mTOR inhibitors inhibits inhibition anti-proliferatives proliferation PI103 22.568281495123
10010177 PI3-Kinase α Inhibitor 2 Exclusive 371943-05-4 ≥98% ✓ 2007-08-02 25.476615510538 pi3-kinase-inhibitor-2 PI3Kα Inhibitor 2; Phosphatidylinositol 3-Kinase α Inhibitor 2 phosphoinositides 3-kinases PI3-kinase phosphatidylinositols cancers proliferations inhibits inhibitors inhibition PI3-K PI3K inhibitory A375 melanoma cell proliferation 25.476615510538
13326 Pifithrin-α 63208-82-2 ≥95% 2009-07-16 26.307106353591 pifithrin p53 apoptosis DNA damage cyclin D1 C8 cells HUVECs endothelial cells dependent independent inactivator 26.307106353591
10748 Pifithrin-μ 64984-31-2 ≥98% 2011-06-20 16.692451657459 pifithrin PFT-μ; 2-Phenylethynesulfonamide p53 apoptosis Bcl-xL Bcl-2 mitochondria inhibitors nutlin heat shock proteins 70 HSP70 PES PAS pifithrin-mu pifithrin mu PFTμ PFTu 2-phenylacetylenylsulfonamide 2-phenylacetylenesulfonamide BclxL Bc12 16.692451657459
10009210 PIK-75 372196-67-3 ≥98% 2010-03-10 13.776209126253 pik-75 p110α PI3K insulin signaling signals cancers inhibitors inhibits inhibition signalling p110a phosphatidylinositol 3-kinase phosphorylation Akt activation mTORC1 PIP2 PIP3 p110β p110α p110γ p110beta p110 alpha p110.beta. p110.alpha. p110gamma p110.gamma.p110g Mixtures, Sulfonamide Sulfonamide Mixtures Sulfonamides 13.776209126253
13212 Pimelic Diphenylamide 106 Exclusive 937039-45-7 ≥98% ✓ 2009-09-30 18.483024134922 pimelic-diphenylamide-106 inhibitors inhibits inhibitions class I histone deacetylases HDACs SAHA HDAC1 HDAC2 HDAC3 HDAC8 II HDAC4 HDAC5 HDAC7 benzamides friedrich ataxia huntington disease 18.483024134922
13368 Piroxicam 36322-90-4 ≥95% 2010-01-06 3.501417463240 piroxicam NSC 666076; Larapam; Feldene inflammation NSAIDs inhibitors cyclooxygenases COX-1 COX-2 analgesic pain arthritis cancers Artrooxicam Baxo Bruxicam CP 16171 Geldene Neoxicam Reudene Roxicam Roxiden Sasulen Solocalm Uphaxicam Zunden inhibition inhibited inflammatory Piroxicam CP-16171 CP 16171 Feldene CP16171 3.501417463240
10728 PIT-1 Exclusive 53501-41-0 ≥98% ✓ 2011-03-25 11.615028182376 pit-1 PIP3 PtdIns-(3,4,5)-P3 PH domains cancers inhibitors Akt PDK1 PTENs proteins binding pituitary-specific transcription factors pit-1 pituitary-specific pit 1 GHF-1 GHF 1 pit-oct-unc pit oct unc POU growth hormones 11.615028182376
10459 PKC 412 120685-11-2 ≥98% 2010-07-27 25.560131929891 pkc-412 CGP 41251; N-Benzoylstaurosporine; Midostaurin; CGP 41231 inhibitors inhibits inhibition PKC412 PKC-412 serine/threonine serine threonine tyrosines kinases PKCα PKCβ PKCγ PKC-α PKC-β PKC-γ Syk Flk-1 Flk1 Akt PKA c-Kit cKit C-Fgr cFgr FLT3 FLT-3 PDFRβ PDFR-β VEGFR1 VEGF2 nitric oxide synthase eNOS apoptosis cancers angiogenesis signal transduction Staurosporine 25.560131929891
13198 PP2 172889-27-9 ≥98% 2010-09-20 28.396000000000 pp2 AGL 1879 PTK inhibitors inhibits inhibition Src kinase T cells T-cells enzymes AG1879 AG 1879 PP-2 PP 2 signalling tyrosine kinases tyrosine focal Tyr 577 adhesion kinases AG-1879 AGL1879 AGL 1879 thaliana Proteins Arabidopsis Proteins Arabidopsis thaliana Arabidopsis thaliana Proteins Hemagglutinins Plant Thale Cress Proteins Plant Hemagglutinins Arabidopsis Proteins Agglutinins Plant Plant Agglutinins Proteins Plant Phytagglutinins Plant Proteins Lectins Plant Plant Lectins 28.396000000000
13643 PP242 1092351-67-1 ≥95% 2011-04-22 13.905426934432 pp242 mTORs mTORC1 mTORC2 inhibitors cancer leukemia rapamycin PP 242 PP-242 inhibited inhibition 13.905426934432
13327 PPM-18 65240-86-0 ≥95% 2010-09-15 9.159502762431 ppm-18 NSC 73233 inhibitors inhibits inhibition NF-κB NFκB NF κB NF-kB NFkB kB iNOS inflammation sepsis inducible nitric oxides synthases inflammatory NO Naphthalenediones Naphthoquinones Naphthazarins 9.159502762431
75760 PPOH 206052-01-9 ≥99% 56.620497237569 ppoh selective epoxygenases inhibitors inhibits acetylenic fatty acids cytochromes CYP450-4A2 CYP450-4A3 CYP450-4A1 CYP-450-4A2 CYP-450-4A3 CYP-450-4A1 CYP-4A2 CYP-4A1 CYP-4A3 endocrinology 56.620497237569
10010343 Pravastatin (sodium salt) 81131-70-6 ≥98% 2008-03-04 17.938365780935 pravastatin-sodium-salt atherosclerosis HMGCoA HMG-CoA reductase LDL-c HDL-c statins cholesterol heart diseases CVD pravachol lipostat inhibitors inhibits inhibitions cardiovascular 17.938365780935
13621 Pristimerin Exclusive 1258-84-0 ≥98% ✓ 2010-03-08 49.274348855564 pristimerin Celastrol methyl ester; NSC 99281 monoacylglycerol lipases MAGLs monoglycerol MGLs cannabinoids 2-arachidonoyl glycerol 2-AG inhibitor 2-Picenecarboxylic acids cannabinoids cbs synthetic Triterpenes 49.274348855564
10011724 Propenyl-L-NIO (hydrochloride) Exclusive - ≥90% ✓ 2008-08-19 8.798936464088 propenyl-l-nio-hydrochloride ENIPO nitric oxide synthase NOS iNOS selective inhibitors inhibits inhibition 8.798936464088
13527 Pseudolaric Acid B 82508-31-4 ≥98% 2009-12-04 5.961823204420 pseudolaric-acid-b PAB Pseudolarix kaempferi traditional Chinese fungal fungus infections cancers apoptosis angiogenesis tumors inhibits inhibitors inhibition P. therapy apoptosis cells 5.961823204420
10817 Pyrovalerone Exclusive 3563-49-3 ≥95% ✓ 2011-05-25 36.642393687258 pyrovalerone Thymergix; Centroton; Valerophenone inhibitors neurotransmitters dopamine norepinephrine controlled substances forensic analysis forensics bath salts 10836 valerophenone 36.642393687258
10836 Pyrovalerone (hydrochloride) 1147-62-2 ≥95% 2011-05-24 43.955073284603 pyrovalerone-hydrochloride Centroton; Thymergix; Valerophenone inhibitors neurotransmitters dopamine norepinephrine controlled substances forensic analysis forensics bath salts inhibition 10817 free base inhibits 3563-49-3 43.955073284603
13294 Pyrrophenone 341973-06-6 ≥90% 2010-04-07 48.304680347276 pyrrophenone phospholipase A2 group IVA phospholipase A2 PLA2 cytosolic PLA2 cPLA2 arachidonic acid AA prostaglandins PG leukotrienes LT inhibitors PGE2 LTB4 blood secretory type PLA2 sPLA2 inflammation inhibition inhibits inflammatory Pyrrolidines 48.304680347276
10006734 QNZ 545380-34-5 >98% 2005-12-16 24.020738950276 qnz CAY10470 inhibits inhibitor inhibition NF kB NF-kB NF-.kappa.B nuclear factors transcription proinflammatory cytokines TNFa TNF.alpha. interleukins IL-1b IL-1.beta. IL-6 IL-8 activation Jurkat cells LPS lipopolysaccharides murine splenocytes in vivo edema carrageenin rat hind paw NF-kappaB nfkb nf-kb NF-.kappa.B 24.020738950276
9000336 (R)-(+)-Acenocoumarol 66556-77-2 ≥98% 2009-06-25 1.159602209944 -r-acenocoumarol (R)-(+)-Nicoumalone; (R)-(+)-Acenocoumarin thrombosis vitamin k warfarin bleeding blood coagulation inhibitors anticoagulants G-23350 Sintrom Sinthrome coumarins 1.159602209944
13089 Radicicol 12772-57-5 ≥98% 2009-02-24 5.146625584359 radicicol Monorden; NSC 294404; KF9-A; KF58332 Hsps antibiotic antifungal antimalarial inhibitors inhibits inhibition heat shock proteins 90 Hsp90 topoisomerase radisicol R 2146 NSC-294404 NSC294404 Monordene KF9A KF 58332 KF-58332 KF-9A 5.146625584359
13346 Rapamycin 53123-88-9 ≥95% 2009-10-21 44.025417638632 rapamycin Sirolimus immunosuppresssants transplants rejection inhibitors IL-2 lymphocytes B cells T FKBP12 mTOR mTORC1 cancer adipogenesis diabetes tuberous sclerosis cardiovascular diseases 44.025417638632
13900 Resveratrol-3-O-Sulfate 553662-69-4 ≥98% 2011-06-01 14.665722178374 resveratrol-3-o-sulfate polyphenol phytoalexin biochemicals physiological actions estrogenic antiplatelet anti-inflammatory piceid polydatin grape juices glucuronidated metabolites humans 14.665722178374
70255 (R)-Flurbiprofen 51543-40-9 ≥99% 2004-06-11 8.886160220994 -r-flurbiprofen E-7869; Tarenflurbil; Flurizan cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits inhibition neurochemistry 8.886160220994
10010309 RG-13022 149286-90-8 ≥98% 2008-01-24 1.878891081294 rg-13022 protein tyrosine kinase PTK inhibitors inhibits inhibition antiproliferatives tyrphostin epidermal growth factors EGFs receptors cancers 1.878891081294
10010310 RG-14620 136831-49-7 ≥98% 2008-02-08 1.569600509987 rg-14620 protein tyrosine kinases PTKs inhibitors inhibits inhibition antiproliferative tyrphostin epidermal growth factors EGFs receptors proliferation cancers 1.569600509987
13293 Rhapontigenin Exclusive 500-65-2 ≥98% ✓ 2009-11-10 25.833729281767 rhapontigenin resveratrols antioxidants cancers cytochromes P450 CYP450 proliferation anti cancers anti-oxidants 25.833729281767
13616 (R)-Lisofylline 100324-81-0 ≥98% 2010-05-27 1.331906077348 -r-lisofylline (R)-LSF; (-)-Lisofylline pentoxifylline phosphatidic acid shock sepsis anti-inflammatory IFN-γ IL-12 β-cell insulin diabetes interleukins 12 IL IFN-gamma 1.331906077348
10311 (R)-(−)-Mellein New 480-33-1 ≥98% 2012-01-13 0.567164179104 -r-mellein Ochracin antibacterial antimalarial antifungal anticancer dihydroisocoumarin A. ochraceus wilhelm proliferation humans breasts cancers melanoma cells 21499-22-9 isocoumarin R-mellein MCF-7 MDA-MB-468 SK-MEL-28 (R)-mellein malme-3M 0.567164179104
13697 (R)-MG132 Exclusive 1211877-36-9 ≥98% ✓ 2010-06-22 102.382928176796 -r-mg132 ubiquitin proteasomes inhibitors proteolytic degradation inflammation cells cycle regulation cancers NF-κB apoptosis inhibition inhibited 102.382928176796
13300 Ro 31-6045 113963-68-1 ≥98% 2009-07-28 11.995243484569 ro-31-6045 Bisindolylmaleimide V PKC kinase inhibitors S6K mitogen-stimulated proteins p70 p85 protein kinases C 11.995243484569
13333 Ro 31-7549 (acetate) 138516-31-1 ≥98% 2009-07-30 11.911528325192 ro-31-7549-acetate Bisindolylmaleimide VIII PKC isozyme inhibitors phospholipases cells signalling signaling SH-SYSY neuroblastoma 125313-65-7 inhibits inhibitions 11.911528325192
13334 Ro 31-8220 (mesylate) 138489-18-6 98% 2009-10-28 23.479260025799 ro-31-8220-mesylate Bisindolylmaleimide IX bisindolylmaleimide inhibitor protein kinase C PKC PKC-α PKC-βI PKC-βII PKC-γ PKC-ε PKA CaM kinase II glycogen synthase kinase-3 GSK-3 Ro318220 GSK3 125314-64-9 Ro-31-8220 75-75-2 23.479260025799
10011132 Rolipram 61413-54-5 ≥98% 2008-12-16 11.059300184162 rolipram ZK 62711; SB 95952 inhibits inhibitor inhibition phosphodiesterase PDE4 cAMP inflammation leukocyte LPS TNF monocytes C5a LTC4 eosinophil neurons bones loss 11.059300184162
10009569 (R)-Roscovitine 186692-46-6 ≥98% 2007-09-04 18.619401473296 -r-roscovitine Seliciclib cell cycle cyclin-dependent kinase cdk proliferation cancer renal disease 18.619401473296
13343 RSC-3388 337307-06-9 ≥95% 2010-02-15 10.927624309392 rsc-3388 cytosolic phospholipases A2 cPLA2 cPLA2α arachidonic acids eicosanoids platelet-activating factors PAF inhibitors inhibits inhibition inflammation dermatitis acrylamides 10.927624309392
9001095 (S)-2-Diphenylmethylpyrrolidine (hydrochloride) New 188398-87-0 ≥98% 2011-12-02 13.545495141287 -s-2-diphenylmethylpyrrolidine-hydrochloride (S)-Desoxy-D2PM NMR analysis dopamine transporter inhibitors stimulants psychoactive forensics 119237-64-8 inhibits inhibition desoxypipradrol 2-diphenylmethylpiperidine 13.545495141287
13664 S32826 1096770-84-1 ≥98% 2010-06-18 15.685453038674 s32826 Autotaxins lysophospholipase D lysophosphatidylcholine lysophosphatidic acids LPAs inhibitors src phosphatase 1B adipocytes plasma inhibited inhibition inhibits Esters, Phosphonic Acid Phosphonic Acid Esters Phosphonic Acids Phosphonates 15.685453038674
9000337 (S)-(−)-Acenocoumarol 66556-78-3 ≥98% 2009-06-25 1.159602209944 -s-acenocoumarol (S)-(-)-Nicoumalone; (S)-(-)-Acenocoumarin thrombosis vitamin k warfarin bleeding blood coagulation inhibitors inhibition inhibits sintrom sinthrome G-23350 G23350 1.159602209944
10009929 SAHA 149647-78-9 ≥98% 2007-08-07 111.847118621265 saha Vorinostat; Suberoylanilide Hydroxamic Acid; Zolinza™ HDACs inhibitors cancers inhibits inhibition 111.847118621265
13178 Salermide 1105698-15-4 ≥98% 2009-04-27 19.070710339384 salermide Sirtuin SIRT1 SIRT2 inhibitors cancers apoptosis leukemias histone deacetylases HDACS inhibition inhibited 19.070710339384
13628 Salidroside 10338-51-9 ≥97% 2010-05-28 17.793057090239 salidroside Rhodioloside glycosides plants Rhodiola Chinese medicine memory infections inflammation cancers diabetes fatigue apoptosis Glucosides 17.793057090239
13579 Salinomycin (sodium salt) 55721-31-8 ≥90% 2011-03-14 15.175138121547 salinomycin-sodium-salt cancers stem cells breasts inhibitors tumors anticancer pyrans anti-cancer inhibited inhibits inhibition CSCs 15.175138121547
10949 Sampling Tubes with PHMB - 2011-06-01 125.900552486188 sampling-tubes-with-phmb 4-(hydroxymercuri)Benzoic Acid spi-bio spibio tubes sampling PHMB inhibitors inhibits cystein protease cystein-protease thiol-specific thiol specific blocker blocking blocks EIA kits serines peptides biomarkers 125.900552486188
13067 SB 203580 152121-47-6 ≥98% 2009-01-14 25.219138121546 sb-203580 RWJ 64809; PB 203580 MAPKs signal transduction p38 kinases cytokines inflammation immune response PI3-kinase PDK1 apoptosis inhibitors inhibits inhibition sb203580 25.219138121546
13344 SB 203580 (hydrochloride) 869185-85-3 ≥98% 2009-09-08 18.550865561694 sb-203580-hydrochloride PB 203580; RWJ 64809 inhibitors inhibits inhibitions MAPK signal transduction p38 kinase PI3 PDK1 18.550865561694
10010246 SB 216763 280744-09-4 ≥98% 2008-06-11 15.691381215469 sb-216763 inhibitors inhibits inhibition GSK-3 GSK3 PI3K glycogen synthase kinase-3 sb216763 15.691381215469
13336 SB 225002 182498-32-4 ≥95% 2009-07-08 101.920939226519 sb-225002 CXCR2 IL-8RB IL-8 CXCL8 Gro-α CXCL1 inflammation chemokines neutrophils angiogenesis inhibitors colitis chemotaxis IL8 IL8RB Groα inhibition inhibits sb225002 101.920939226519
10096 SB 242084 (hydrochloride) 1049747-87-6 ≥98% 2010-06-29 1.280536700867 sb-242084-hydrochloride 181632-25-7 serotonins 5-hydroxytryptamines 5-HT neurotransmitters neuroscience receptors gut central nervous system antagonists 5-HT2C dopamine adrenergic receptors brain anxiolytic neurochemistry CNS Antigens HLA-SB Antigens HLA-PL Antigens HLA-DP HLA-SB Antigens HLA-PL Antigens HLA-DP Antigens HLA SB Antigens HLA PL Antigens HLA DP Antigens HLA-SB HLA-PL HLA-DP 1.280536700867
10010247 SB 415286 264218-23-7 ≥98% 2008-10-29 12.584364640884 sb-415286 GSK3 GSK-3 PI3K signaling PI3K signalling glycogen synthase inhibitors inhibits inhibition neuron survival glycogen synthesis Chang human liver cells line potent selective sb415286 12.584364640884
13031 SB 431542 301836-41-9 ≥98% 2009-08-10 104.892580110497 sb-431542 inhibitors inhibits inhibitions TGF-β1 TGFβ1 receptors ALK5 ALK4 ALK7 ALKs BMP ALK2 ALK3 ALK6 kinases Smad fibrosis cancers renewal embryonic stems cells induced pluripotent differentiation SB431542 104.892580110497
10443 SB 939 New 929016-96-6 ≥98% 2012-02-06 7.126284948937 sb-939 Pracinostat inhibits inhibitions inhibitor HDACs pan-HDAC panHDAC SB939 SB-939 histones deacetylase proliferation voronistat cancers tumors SAHA ovarian A2780 colon COLO205 HCT-116 prostate PC-3 7.126284948937
10011561 SC-51089 146033-02-5 ≥95% 2010-02-02 10.908080110497 sc-51089 CID132748 prostaglandins E2 PGE2 receptors EP1 pain antagonists analgesia glioma cells cancers tumors growth neuroprotection neurons oxidative stress SC51089 SC 51089 PGs Oxazepines 10.908080110497
10010267 SC-514 354812-17-2 ≥98% 2009-08-07 30.175450747877 sc-514 SC514 SC 514 inhibitors inhibits inhibitions IκB kinase IkB IKK2 NF-κB NFκB IL-1β IL1β genes expressions IL-6 IL6 IL-8 IL8 COX-2 COX2 iNOS LPS smooth muscles cells TLR2 TNF astrocytes 30.175450747877
70340 SC-560 188817-13-2 >98% 63.529257213014 sc-560 SC560 cyclooxygenases prostaglandins synthases COX-1 pghs-1 inhibits inhibitors selective 63.529257213014
70655 SC-58125 162054-19-5 >98% 19.554233425413 sc-58125 selective inhibitors inhibits COX-2 cox2 pghs2 pghs-2 prostaglandin synthases synthase-2 sc58125 cyclooxygenases diaryl heterocycles time-dependent 19.554233425413
10876 SC-66 871361-88-5 ≥98% 2011-06-21 12.421801104972 sc-66 SC66 SC 66 analogs cyclohexanone curcumin cancers Akts inhibitors inhibits inhibition cancers ubiquitination cells death tumors tumorigenesis 12.421801104972
89460 Sclerotiorin 549-23-5 ≥98% 2009-03-11 29.300626151013 sclerotiorin Lipoxygenase-1 inhibitor CETP Grb2 Endothelins ETa ETb LO-1 ETs LOs Penicillium soybean inhibits inhibition antagonism antagonists 29.300626151013
10572 Scriptaid 287383-59-9 ≥98% 2010-09-27 43.534185082873 scriptaid GCK 1026 histones deacetylases HDACs inhibitors inhibition inhibits cancers cloning cells arrest somatic nuclear transfers Scriptides trichostatin A mouse inbred strains somaic GCK-1026 GDK1026 hydroxylamines 43.534185082873
10004207 (S)-Flurbiprofen 51543-39-6 ≥99% 2004-06-11 12.827425414365 -s-flurbiprofen cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits inhibition (S)Flurbiprofen 12.827425414365
13332 (S)-Glycyl-H-1152 (hydrochloride) Exclusive 913844-45-8 ≥98% ✓ 2010-01-27 83.825403314916 -s-glycyl-h-1152-hydrochloride Rho Kinase Inhibitor IV Rho kinases ROCK-I p160ROCK ROCK-II G protein Rho cytoskeletons adhesions proliferation smooth muscles contraction stem cells inhibitors inhibition inhibited Fasudil hydrochloride ROCK IV h1152 h-1152 h 1152 83.825403314916
10007653 (S)-H-1152 (hydrochloride) 451462-58-1 ≥95% 2010-02-25 31.991988950276 -s-h-1152-hydrochloride Rho kinase ROCK cytoskeletal cytoskeleton smooth muscles contractions vasoconstriction neurons neurite inhibitors Y-27632 HA-1077 PKA PKC MLCK H1152 H 1152 inhibition inhibits 451462-58-1 1-(5-Isoquinolinylsulfonyl)-2-Methylpiperazine 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine H-7 H 7 h1152 h-1152 h 1152 31.991988950276
13277 (S)-HDAC-42 935881-37-1 ≥95% 2009-12-03 27.127075354659 -s-hdac-42 AR42 histones deacetylases HDACs cancers inhibitors prostate p21 Akt Bcl-XL tumors inhibition inhibits OSU-HDAC-42 27.127075354659
10010344 Simvastatin 79902-63-9 ≥98% 2008-02-27 23.698791984565 simvastatin MK 733 HMG-CoA reductase HMGCoA inhibits inhibitors inhibition LDL-c HDL-c statins cholesterol heart diseases CVD atherosclerosis zocor zetia exetimibe vytorin inegy TNF-.alpha. NF-.kappa.B apoptosis cancers cardiovascular NFkB atherosclerosis 23.698791984565
10523 Sirtinol New 410536-97-9 ≥98% 2012-03-29 42.270114942529 sirtinol Sir Two Inhibitor Naphthol inhibitors inhibits inhibition histones deacetylases sirtuins cancers inflammation plants biology cells NAD+ yeast Sir2p humans 42.270114942529
10009312 SKF-96365 (hydrochloride) 130495-35-1 ≥98% 2007-01-19 47.533237569061 skf-96365-hydrochloride calcium antagonists voltage-gated inhibits inhibitors inhibition acetylcholine-induced depolarization smooth muscles platelets neutrophils SFK9635 Ach-induced HCl neurochemistry 47.533237569061
13617 (S)-Lisofylline Exclusive 100324-80-9 ≥98% ✓ 2010-05-27 1.174447513812 -s-lisofylline (S)-LSF; (+)-Lisofylline pentoxifyllines phosphatidic acid shock sepsis anti-inflammatory IFN-γ IL-12 β-cell insulin diabetes antiinflammatory inflammatory inflammation inflammed 1.174447513812
10012628 (S)-MG132 133407-82-6 ≥98% 2009-02-18 179.218132596685 -s-mg132 Z-Leu-Leu-Leu-CHO ubiquitin proteasome inhibitors inhibits inhibition proteolytic degradation inflammation cell cycle regulation cancers NF-kB NFkB apoptosis NF-κB mg 132 mg-132 2-LLL-CHO 179.218132596685
11029 SMI-4a New 327033-36-3 ≥95% 2012-03-14 20.000000000000 smi-4a serine/threonine kinases Pim cancers rapamycin-sensitive mammalian target of rapamycin mTORC1 AMPK leukemia inhibitors inhibits inhibition SMI4a SMI 4a cells myeloid lymphoid T-cells T cells lymphoma apoptosis tumors Ser/Thr 20.000000000000
70290 (S)-Naproxen 22204-53-1 >99% 21.061152445263 -s-naproxen cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits 21.061152445263
13121 Sodium Butyrate 156-54-7 ≥95% 2009-07-31 57.741817065684 sodium-butyrate Butyric Acid (sodium salt) fatty acids short chains inhibitors inhibits inhibition histones deacetylases HDACs epigenetics growth arrest differentiation apoptosis cancers inflammation genes expressions pro-inflammatory proinflammatory cytokines IFN-γ IL-6 IFNγ IL6 IL-1β IL1β IFNg 57.741817065684
10010466 SP 600125 129-56-6 ≥98% 2009-01-07 11.780883977900 sp-600125 1PMV; Pyrazolanthrone; NSC 75890 c-Jun cJun JNKs inhibitors inhibits inhibition reversible cell-permeable cells COX-2 COX2 MAP kinase MAPK genes expressions apoptosis autophagy differentiation IL-10 IL10 TNF-α TNFα IFN-γ IFNγ T-cells Tcells HeLa sp600125 11.780883977900
10004883 sPLA2 (Type V) Inhibitor Screening Assay Kit - 2004-05-07 52.717553275453 spla2-type-v-inhibitor-screening-assay-kit Secretory Phospholipase A2 (Type V) assays measures kits inhibition inhibitors phospholipases inflammation eicosanoids colorimetric sPLA2s enzymes diheptanoyl thio-pc 52.717553275453
13168 Splitomicin 5690-03-9 ≥98% 2010-07-15 13.082355958958 splitomicin 1-Naphthalenepropanoic Acid sirtuins Sir2p Sir-2p Sir 2p SIR2 NAD NAD+-dependent NAD-dependent dependent histone deacetylase activity activities genes regulations lifespan life-span life span yeast expression DNA replication inhibitor inhibits inhibition Hst1 Hst-1 Hst 1 HDACs chromatin research epigenetics regulation modification Sirs small molecules Pyrones 13.082355958958
13339 SQ 22,536 New 17318-31-9 ≥95% 2012-05-09 34.665580110497 sq-22-536 NSC 53339 inhibitors inhibits inhibition adenylyl cyclases cAMP platelets iloprost vasorelaxation pulmonary veins vascular smooth muscles prostaglandins PGs PGE PGE1 E1 SQ 22536 SQ22,536 SQ-22,536 34.665580110497
10922 SR 1001 - ≥98% 2011-06-28 59.075591160220 sr-1001 inflammation autoimmune diseases RORα RORγ retinoic-acid-receptor-related orphans receptors IL-17 TH17 cells ligands mutiple sclerosis MS agonists differentiation PBMCs inhibits inhibitors inhibition splenocytes NCoR SR1001 SR-1001 59.075591160220
9000491 SR 144528 192703-06-3 ≥98% 2009-08-05 72.405013812154 sr-144528 antagonist CB1 CB2 cannabinoids receptors inverse agonist inflammation leukocytes CP 55940 CP55940 55,940 CP55,940 pain initiation suppression immune activation sr144528 CBs synthetic 72.405013812154
10009022 (S)-SLV 319 Exclusive 464213-10-3 ≥98% ✓ 2007-08-16 0.254419889503 -s-slv-319 CB1 CB2 receptors cannabinoids antagonists inflammation obesity neurochemistry inflammatory neuro-inflammatory neuroinflammatory (S)-SLV319 disorders ligands 0.254419889503
13337 ST638 107761-24-0 ≥98% 2010-09-21 24.500860299921 st638 tyrosine kinases inhibitors inhibits inhibition cell signaling signalling receptors tumor necrosis factor phosphorylation TNF-α phorbol myristate acetate PMA cardiac fibroblasts TNFα TNF α TNFalpha TNF.alpha. 24.500860299921
81590 Staurosporine 62996-74-1 >98% 21.359733917571 staurosporine Stsp inhibitor inhibits protein kinase pkc-alpha pkc-.alpha. eNOS endothelial nitric oxide synthases 21.359733917571
9000631 Stearoyl Serotonin Exclusive 67964-87-8 ≥98% ✓ 2010-05-18 6.930797158643 stearoyl-serotonin N-arachidonoyl serotonin AA-5-HT AA-5HT antagonists fatty acids amide hydrolase FAAH transient receptors potential vanilloid-type 1 channels TRPV1 pain capsaicin ethanolamine anandamide AEA Hydrolase Desaturase Stearoyl-CoA Stearoyl-CoA Desaturase Stearoyl CoA Desaturase Desaturase Stearyl-CoA Stearyl-CoA Desaturase Stearyl CoA Desaturase Desaturase Stearate Stearate Desaturase Desaturase delta-9 delta-9 Desaturase 6.930797158643
13084 STF-62247 315702-99-9 ≥98% 2009-10-07 33.988508287293 stf-62247 autophagy lethality renal cells carcinoma cancers von Hippel-Lindau VHL tumors supressors genes growth rates kidneys metastasize syndrome diseases 33.988508287293
13338 SU 6656 330161-87-0 ≥95% 2009-08-04 23.932662983425 su-6656 inhibitors Src kinases Src Yes Lyn Fyn cells growth development nervous system fibrosis cancers inhibits inhibition CNS SU6656 23.932662983425
10574 Suberohydroxamic Acid 38937-66-5 ≥98% 2010-09-28 21.781184392264 suberohydroxamic-acid SBHA; Suberic bis-Hydroxamic Acid histones deacetylases HDACs inhibitors genes expression regulation epigenetics nucleosomes HDAC1 HDAC3 differentiation cells cycle arrest apoptosis cancers suberodihydroxamic acid suberoyl bishydroxamic acid inhibited inhibition Warner-Lambert Brand of Mefenamic Acid Warner Lambert Brand of Mefenamic Acid Pharmascience Brand of Mefenamic Acid First Horizon Brand of Mefenamic Acid Parke Davis Brand of Mefenamic Acid Farmasierra Brand of Mefenamic Acid Ashbourne Brand of Mefenamic Acid Pinewood Brand of Mefenamic Acid Nu-Pharm Brand of Mefenamic Acid Nu Pharm Brand of Mefenamic Acid Chemidex Brand of Mefenamic Acid Gödecke Brand of Mefenamic Acid Clonmel Brand of Mefenamic Acid Antigen Brand of Mefenamic Acid Pfizer Brand of Mefenamic Acid Apotex Brand of Mefenamic Acid Rowa Brand of Mefenamic Acid Elan Brand of Mefenamic Acid APS Brand of Mefenamic Acid PMS-Mefenamic Acid PMS Mefenamic Acid Acid Mefenaminic Mefenaminic Acid Acid Mefenamic Mefenamic Acid Forte Ponstan Ponstan Forte Apo-Mefenamic Apo Mefenamic Nu-Mefenamic Nu Mefenamic ApoMefenamic NuMefenamic Pinalgesic Contraflam Ponalgic Parkemed Ponstel Ponstan Ponalar Mefacit Pontal Ponsyl Ponmel Dysman Coslan Mefic Mefac 21.781184392264
10004386 Sulindac 38194-50-2 >98% 2004-04-20 9.961476934269 sulindac NSAIDS anti-inflammatory inhibitors inhibits cancer COX non-steroidal nonsteroidal drugs cyclooxygenases indomethacin pghs2 cox2 pghs-2 prostaglandin synthases synthase-2 9.961476934269
16860 Swainsonine 72741-87-8 ≥98% 2009-06-12 121.991995089011 swainsonine Tridolgosir Alkaloid N-linked glycoside hydrolases asparagine-linked glycoproteins glycoproteins inhibitor lysosomal α-mannosidase glycosidases Golgi α-mannosidase II N-linked glycosylation antiproliferative proliferation growth antimetastatic metastasis cancer α-mannosidase lysosomes oligosaccharides glycoproteins lysosomal storage disease toxicity locoism 121.991995089011
13085 Tenovin-1 Exclusive 380315-80-0 ≥98% ✓ 2008-09-18 26.669751381215 tenovin-1 histones sirtuins cancers p53 cell growth tumors SIRT1 SIRT2 inhibitors inhibits inhibition melonoma lymphoma 26.669751381215
13086 Tenovin-6 1011557-82-6 ≥95% 2009-02-12 42.828153117600 tenovin-6 histones sirtuins cancers p53 cell growth tumors SIRT1 SIRT2 inhibitors inhibits inhibition SIRTs transcription factors TFs 42.828153117600
10011619 Terbinafine (hydrochloride) 78628-80-5 ≥98% 2010-02-16 4.223204419890 terbinafine-hydrochloride antifungals squalene epoxidase antitumor tumors antiangiogenic anticancer cancers inhibitors inhibits inhibition Naphthalenes 4.223204419890
70302 tetramethyl Nordihydroguaiaretic Acid Exclusive 24150-24-1 ≥98% ✓ 2008-09-24 27.192639656230 tetramethyl-nordihydroguaiaretic-acid tetramethyl NDGA; TMNDGA; Tetrameprocol; M4N; EM-1421 tumors inhibitor inhibits inhibition cancers NDGAs survivin apoptosis Cdc2 HIV growing growth glioma brains antitumor organic melonomas 27.192639656230
10398 TG003 300801-52-9 ≥95% 2011-08-17 3.845303867404 tg003 inhibitors CDC kinasesTG 003 TG-003 TG3 TG-3 TG 3 Cdc2-like kinases Clks serine/arginine-rich proteins splicing RNA Clk1/Sty Clk4 serine rich pre-mRNA Xenopus arginine SR mRNA Sty Clk1 CLk2 Clk3 Clk4 benzothiazole inhibition inhibits inhibitor SF2 SF2/ASF ASF 3.845303867404
10007349 TGX-221 663619-89-4 >98% 2006-02-21 19.982782800379 tgx-221 phosphatidylinositol-3-kinases PI3K catalyzes phosphorylation produces second messengers (3,4)-biphosphates -P2 (3,4,5)-P3 Class 1 p110.alpha. .beta. .delta. .gamma. p85 regulatory subunits cells permeable inhibitors inhibition inhibits ATP binding sites platelets defective thrombus formation antithrombotic therapy atherosclerosis 19.982782800379
10522 Thapsigargin 67526-95-8 ≥97% 2011-09-23 50.668617447869 thapsigargin calcium, ATPases, sarco/endoplasmic calcium ATPases SERCAs cells signaling activation histamine cancers tumorigenesis inflammation reticula sarcoplasmic endoplasmic 50.668617447869
13237 Thiamet G Exclusive 1009816-48-1 ≥97% ✓ 2009-06-25 43.255745856354 thiamet-g inhibitors inhibits inhibitions tau alzheimers disease O-GlcNAc OGlcNAc O-GlcNAcase OGlcNAcase O-GlcNAcylation OGlcNAcylation Thiamet-G 43.255745856354
62750 Thioetheramide-PC 116457-99-9 >95% 29.102168508287 thioetheramide-pc 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine inhibitors thioetheramides inhibits phospholipases phosphorylcholines phosphatidyl cholines inhibitors sPLA2s activity activators 29.102168508287
10009813 thio-Miltefosine - >98% 2007-08-13 7.149613259669 thio-miltefosine analogs inhibitors inhibit inhibition CTP phosphocholine cytidylyl transerases antimetastatic antiproliferatives ceramides apoptosis antiprotazoal thiomiltefosine sulfurs thios 7.149613259669
13693 Tizoxanide 173903-47-4 ≥98% 2011-09-13 0.276243093923 tizoxanide nitazoxanide alinia anti-viral metabolites anti-parasitic giardia lamblia crytosporidium bacteria parasites viruses diseases influenza A hepatitis B C diarrhea 0.276243093923
10010516 TMP-153 New 128831-46-9 ≥95% 2012-05-08 82.914836446549 tmp-153 Acyl-CoA:cholesterol acyltransferases ACAT cholesterol esterification atherosclerosis inhibitors inhibits inhibition LDL TMP153 TMP-153 cells fatty acids intestinal absorption vascular tissues plasma lipids proteinuria low density lipoprotein high HDL HepG2 L-S180 LS180 L S180 82.914836446549
13074 Tosyllysine Chloromethyl Ketone (hydrochloride) 4238-41-9 ≥98% 2009-02-26 30.687053406998 tosyllysine-chloromethyl-ketone-hydrochloride TLCK (hydrochloride); 1-Chloro-3-Toxylamide-7-Amino-L-2-Heptanone (hydrochloride) TLCKs proteinase inhibitors inhibits inhibition trypsin serine histones protease proteins purifications 4272-74-6 30.687053406998
11120 TPPU Exclusive 1222780-33-7 ≥98% ✓ 2011-10-26 5.145469613259 tppu soluble epoxide hydrolase sEH inflammation hypertension cardiovascular disease neuroscience inhibitors inhibits inhibition pharmacokinetics 5.145469613259
13044 Tranilast 53902-12-8 ≥98% 2008-08-29 71.116731123388 tranilast SB 252218; Rizaben; MK 341; Tranpro; N-(3',4'-Dimethyoxycinnamoyl)Anthranilic Acid anti-inflammatory antiinflammatory angiogenesis PGDF TGF-.beta.1 TGF.beta.1 IL-8 IL8 PGE2 TXB2 antiallergenic anti-allergenic atherosclerosis vascular disease VEGF 71.116731123388
9000784 (−)-trans-C75 Exclusive 1234694-22-4 ≥98% ✓ 2011-07-20 8.457845303867 -trans-c75 (2S,3R)-C75 trans C75 transC75 inhibitors inhibits inhibition fatty acids synthases FAS apoptosis cancers obesity C-75 apoptosis 8.457845303867
9000783 (+)-trans-C75 Exclusive 1234694-20-2 ≥98% ✓ 2011-07-20 8.457845303867 -trans-c75 (2R,3S)-C75 transC75 trans C75 fatty acids synthases FAS apoptosis cancers obesity inhibitors inhibits inhibition C-75 8.457845303867
70675 trans-Resveratrol 501-36-0 >98% 90.910582583043 trans-resveratrol (E)-Resveratrol selective cyclooxygenases inhibitors COX-1 PGHS-1 COX1 PGHS1 prostaglandins H synthases 1 antioxidants oxidative injury stress atherosclerosis sirtuins 3,5,4'-trihydroxystilbene 3,5,4'-trihydroxy-trans-stilbene 3,5,4'-THS 3,5,4'-trimethoxy stilbene 3,5,4'-trimethoxystilbene (E)-stilbenes AHR antagonists aryl hydrocarbon receptors 90.910582583043
13130 trans-Resveratrol-d4 - ≥99% deuterated product 2009-01-14 20.881717311234 trans-resveratrol-d4 (E)-Resveratrol-d4 selective cyclooxygenases inhibitors COX-1 PGHS-1 COX1 PGHS1 prostaglandins H synthases 1 antioxidants oxidative injury stress atherosclerosis deuterated LC/MS GC-MS LC-MS mass spectrometry deuterium sirtuins AHR antagonists aryl hydrocarbon receptors 20.881717311234
10010237 Triciribine 35943-35-2 ≥98% 2007-09-11 6.821546961326 triciribine Tricyclic Nucleoside; NSC 154020; API 2 Akt cancers inhibitors inhibition inhibits Akt-1 Akt1 Akt-2 Akt2 Akt-3 Akt3 PI3-kinase PI3kinase PI3K PI-3-kinase phosphorylation activation signalling pathway signaling 6.821546961326
10009083 Trimidox Exclusive 95933-74-7 ≥98% ✓ 2008-02-13 4.169060773481 trimidox VF 233 apoptosis ribonucleotide reductases cells cycles cancers dNTP HIV caspase DNA synthesis chemotherapy dGTP HL-60 4.169060773481
10011124 Trimidox (hydrochloride) Exclusive - >98% ✓ 2008-06-10 4.169060773481 trimidox-hydrochloride CF 233 (hydrochloride) apoptosis ribonucleotides reductases cells cycles cancers dNTP HIV caspases DNA synthesis chemotherapy dGTP HL-60 HCls 4.169060773481
10559 Tubastatin A (trifluoroacetate salt) Exclusive - ≥95% ✓ 2011-02-08 38.988967541436 tubastatin-a-trifluoroacetate-salt HDAC6 inhibitors histones deacetylases neuroprotection neurons epigenetics TFA inhibition inhibited neuronal protection α-tubulin alpha tubulin .alpha.tubulin a-tubulin tubastatin-A Acids Hydroxamic Hydroxamic Acids Acid Hydroxamic Hydroxamic Acid 38.988967541436
11445 Tunicamycin New 11089-65-9 ≥95% (mixture of isomers) 2012-05-01 81.758023750555 tunicamycin 11118-26-6 N-linked glycosylation post-translational modifications proteins folding inhibitors inhibition inhibits antibiotics glycoproteins EGFR ErbB2 ErbB3 IGF-IR ALK cancers palmitoylation oligomerization cells endoplastic reticulum amino acids Golgi plasma membranes nucleoside U251 glioma BXPC3 phosphorylation 81.758023750555
10011251 TWS119 601514-19-6 ≥90% 2008-12-11 20.695616942910 tws119 inhibitors inhibits inhibition stem cells differentiation neurogenesis neuron kinases GSK-3β GSK3β TWS 119 TWS-119 20.695616942910
70970 U-0126 109511-58-2 >98% 2007-11-20 25.999250197316 u-0126 U0126 MAPK MAP Kinases inhibitors inhibits inhibition MEK MEK1 MEK2 signal transduction ATP adenosine triphosphate U 0126 25.999250197316
10009085 U-18666A 3039-71-2 >95% 2007-01-19 28.064353591161 u-18666a Niemann-Pick type C NPC apoptosis neuronal death Alzheimers AD neurodegeneratives diseases trafficking unesterified ER cells membranes cateracts epilepsy Free cholesterol loading NSC 70801 Endoplasmic reticulum atherosclerosis inhibits inhibitors inhibition endosomes lysomes oxidosqualene cyclases atherosclerosis 28.064353591161
70740 U-73122 112648-68-7 ≥97% 48.615801104973 u-73122 inhibitors inhibits PLC phospholipases C HIV-1 integrase u73122 48.615801104973
10045 UCM707 390824-20-1 >98% 2004-01-30 24.558784530386 ucm707 cannabinoids neurotransmitter inhibitors AEA lipids CB1 UR1 receptors anandamide hydrolysis fatty acids neurochemistry neuroscience 24.558784530386
13631 UNC0224 Exclusive 1197196-48-7 ≥98% ✓ 2010-08-10 21.928835529111 unc0224 inhibitors inhibits inhibition histones methyltransferases genes regulation regulator chromatin remodeling UNC 0224 UNC-0224 G9a SET8 SET7/9 lysine HMTase 21.928835529111
10582 UNC0321 (trifluoroacetate salt) Exclusive - ≥95% ✓ 2011-03-15 13.187769964842 unc0321-trifluoroacetate-salt methyltransferases inhibitors histones genes regulation chromatin remodeling G9a HMTase inhibited inhibition potent selective MT SET7/9 SET8 PRMT3 JMJD2E 13.187769964842
10734 UNC0638 1255580-76-7 ≥98% 2011-05-03 22.094889502762 unc0638 methyltransferases inhibitors histones genes regulation chromatin remodeling inhibited inhibition G9a MT GLP PRMT 3 SUV39H2 SET7/9 SET8 inhibits H3K9 dimethylation MDA-MB231 22.094889502762
10046 URB597 546141-08-6 >98% 47.222456052235 urb597 FAAH fatty acid amide hydrolases inhibitors URB-597 anandamides lipids inhibition selective selectivity AEA inhibits hydrolysis hydrolyze arachidonoyl cannabinoids ethanolamides neuroscience neurochemistry 47.222456052235
10674 URB937 Exclusive 1357160-72-5 ≥95% ✓ 2011-03-08 15.000916206261 urb937 FAAH anandamide AEA inhibitors peripheral pain Cannabinoids 15.000916206261
10072 Ursolic Acid New 77-52-1 ≥98% 2012-02-29 94.444444444444 ursolic-acid NSC 4060; Prunol; NSC 167406; Malol; Bungeolic Acid; Maerotaine NSC-167406 NSC167406 NSC-4060 NSC4060 neoage UR ursolisome urson β-Ursolic 209545-05-1 triterpenoid antioxidative antimicrobial anti-inflammatory anticancer Na+ K+ ATPase NF-kB cells proliferation apoptosis inhibitions inhibitors inhibits inflammation cancers 94.444444444444
70670 Valeroyl Salicylate 64206-54-8 >99% 6.397863720073 valeroyl-salicylate 2-Valeryloxybenzoic Acid selective cyclooxygenase inhibitors COX-1PGHS-1 prostaglandin H synthase 1 prostaglandins 6.397863720073
13033 Valproic Acid (sodium salt) 1069-66-5 ≥95% 2009-10-21 32.904732965009 valproic-acid-sodium-salt Sodium Valproate; 2-Propylvaleric Acid valeric acids anticonvulsant seizures inhibitors histones deacetylases HDAC glycogen synthase kinases GSK3 inositol-1,4,5-trisphosphate IP3 combination therapy cancers Alzheimer's diseases stem differentiation self-renewal 32.904732965009
13131 VER-49009 Exclusive 940289-57-6 ≥98% ✓ 2010-07-09 4.866372007366 ver-49009 heat shock proteins Hsp90 inhibitors Hsp27 Hsp72 cells cycle arrest apoptosis inhibits inhibition isoxazole survivin C-RAF B-RAF PRMT5 molecular chaperones folding signalling signaling VER49009 VER 49009 cancers pyrazoles 4.866372007366
13132 VER-50589 Exclusive 747413-08-7 ≥98% ✓ 2010-04-06 4.802453959484 ver-50589 heat shock proteins Hsps Hsp90 cancers inhibitors inhibits inhibition Hsp27 Hsp72 C-RAF B-RAF survivin PRMT5 cells cylce arrest apoptosis tumors growth glioblastoma molecular chaperones protein folding signaling signalling pharma Isoxazoles 4.802453959484
9000976 Vigabatrin 68506-86-5 ≥95% 2011-05-04 5.829033149171 vigabatrin γ-Vinyl GABA; Sabril™ 60643-86-9 neurotransmitters γ-aminobutyric acids GABA inhibitors seizures epilepsy neuroscience gamma-vinyl-gamma-aminobutyric gamma vinyl aminobutyric gamma-vinyl-GABA Sabrilex Sabril 5.829033149171
80330 Vinyl-L-NIO (hydrochloride) 728944-69-2 >98% 2008-08-11 20.943462246776 vinyl-l-nio-hydrochloride nitric oxide synthase NOS nNOS selective inhibitors inhibits inhibition ornithine 20.943462246776
13531 (−)-Warfarin 5543-57-7 ≥98% 2009-10-01 4.626906077347 -warfarin (S)-Warfarin anticoagulants hearts attacks strokes clotting blood cardiovascular diseases vitamins K rodenticides warfarins anti-cogulants 4.626906077347
13526 (+)-Warfarin 5543-58-8 ≥98% 2009-10-01 2.217856353591 -warfarin (R)-Warfarin anticoagulants hearts attacks strokes clotting blood cardiovascular diseases vitamins K rodenticides warfarins anti-cogulants 2.217856353591
13566 (±)-Warfarin 81-81-2 ≥98% 2009-09-29 1.975116022099 -warfarin Coumadin; Zoocoumarin; Coumafene; Athrombine K; WARF 42 anticoagulants heart attacks strokes clotting blood cardiovascular diseases vitamin K rodenticide anti-coagulants racemic mixture liver accumulation accumulates clots 1.975116022099
10010591 Wortmannin 19545-26-7 ≥98% 2008-11-21 30.065709170100 wortmannin KY 12420 phosphoinositide 3-kinase PI3K cells growth differentiations cancers motility inhibitors inhibits inhibition irreversible polo-like kinases PLK1 PLK3 mTOR DNA-PK DNAPK PL4K MLCK p38 MAPK 30.065709170100
13671 Wortmannin-Rapamycin Conjugate - ≥98% 2010-05-11 9.973338789986 wortmannin-rapamycin-conjugate phosphoinositides 3-kinases PI3K mammalian targets mTOR cancers inhibitors inhibits inhibition complex 1 mTORC1 tumors bevacizumab VEGF colons A498 HT29 53123-88-9 sirolimus prodrug linkers links 19545-26-7 KY 12420 renal phosphatidyl inositols 9.973338789986
10011213 WWL70 Exclusive 947669-91-2 >97% ✓ 2008-04-15 17.513604972375 wwl70 serine hydrolase ABHD6 inhibitors inhibits inhibition 2-AG endocannabinoids .alpha./.beta. a/b alpha/beta neurochemistry cannabinoids inhibitors 17.513604972375
13604 WYE-354 New 1062169-56-5 ≥98% 2012-01-12 12.173137712297 wye-354 mTOR mTORC1 mTORC2 inhibitors inhibits inhibition PI3K cancers cells growth PTENs tumors rapamycin complex 1 2 G1 phosphatidylinositol 3-kinase α PI3Kα kinases 12.173137712297
13639 WZ811 55778-02-4 ≥95% 2010-03-22 44.403024861878 wz811 CXC chemokines receptors CXCR4 stromal cell-derived factor-1 SDF-1 CXCL12 hematopoietic stem cells chemotaxis lymphocytes growth metastasis cancers T cells HIV infection inhibitors antagonist cAMP Matrigel invasion breast cancer adenocarcinoma inhibition alpha-Aminotoluene alpha Aminotoluene Phenylmethylamine Benzylamines 44.403024861878
13596 XAV939 284028-89-3 ≥98% 2009-12-03 20.314585635359 xav939 Wnt cancers β-catenin APC axin GSK3 poly-ADP-ribosylation tankyrases TNKS1 TNKS2 inhibitors inhibition inhibits 20.314585635359
10005583 Y-27632 (hydrochloride) 129830-38-2 >98% 2007-11-29 134.186408839779 y-27632-hydrochloride Y27632 inhibitors inhibit inhibition Rho ROCK ROCK-II ROCKII PRK2 smooth muscle contraction cell adhesion signal transduction kinase phosphorylation HCl competative Y 27632 146986-50-7 134.186408839779
11168 (−)-YK-4-279 New - ≥98% 2011-12-19 1.356353591160 -yk-4-279 ES-FLI1 oncogenes Ewing's sarcomas RNA helicases tumors cancers inhibitors apoptosis ETS transcription factors ERG ETV1 prostate fusion proteins diseases YK4279 YK 4279 growth xenografts cells chemotherapy resistant Ewings ESFLI1 ES FLI1 prostate 1.356353591160
11167 (+)-YK-4-279 New 1261038-93-0 ≥98% 2011-12-16 1.356353591160 -yk-4-279 ES-FLI1 oncogenes Ewing's sarcomas RNA helicases tumors cancers inhibitors apoptosis ETS transcription factors ERG ETV1 prostate YK4279 YK 4279 fusion proteins diseases growth orthotopic xenografts cells chemotherapy resistant Ewings EWS-FLI1 reduces in vitro in vivo family prostate cancers enantiomers EWSFLI1 EWS FLI1 1.356353591160
13661 YK-4-279 1037184-44-3 ≥98% 2010-02-05 2.712707182320 yk-4-279 ES-FLI1 oncogene Ewing's sarcomas RNA helicases A RHAs tumors cancers inhibitors apoptosis inhibition inhibited Ewings YK 4-279 YK4279 YK 4279 YK 4 279 Pentaacetic Acid, Diethylenetriamine Acid, Diethylenetriamine Pentaacetic Diethylenetriamine Pentaacetic Acid calcium trisodium pentetate Pentetic Acid DTPA pentacin penthanil 2.712707182320
13576 YM-201636 371942-69-7 ≥95% 2010-04-14 14.184116022099 ym-201636 PIKfyve phosphoinositide kinase PIK zinc finger domains phosphatidylinositol 3-phosphate PI3P PI(3,5)P2 membrane trafficking cytoskeleton inhibitors endosomal trafficking endosomes phagocytosis retrovirus virology adipocytes insulin glucose diabetes YM201636 YM 201636 Aminopyridines 14.184116022099
18113 YM-53601 Exclusive 182959-33-7 ≥98% ✓ 2009-08-11 8.449790055248 ym-53601 squalene synthases inhibitors cholesterol triglycerides HMG-CoA reductase fibrates hyperlipidemia hypercholesterolemia lipid-lowering activities inhibitor inhibited 8.449790055248
13246 YM-58483 223499-30-7 ≥98% 2009-11-16 5.369171270719 ym-58483 BTP 2 calcium channels leukocytes leukotrienes eicosanoids inflammation asthma allergy IL-2 IL-4 lymphocytes eosinophils NF-AT CRACs CysLTs interleukin-4 BTP2 BTP-2 CysLT 5.369171270719
13665 YS121 Exclusive 916482-17-2 ≥98% ✓ 2010-04-02 17.990220994475 ys121 Microsomal Prostaglandin E2 Synthase-1 mPGES-1 cyclooxygenase-2 COX-2 PGE2 inflammation fever pain 5-Lipoxygenase 5-LO leukotrienes LTs inhibitors LTB4 cyclooxygenase-1 COX-1 LTC4 LTD4 LTE4 inhibition Pyrimidines inhibits PGs YS 121 YS-121 17.990220994475
10010421 Zaprinast 37762-06-4 ≥98% 2008-09-18 6.124180478821 zaprinast 2-(o-Propoxyphenyl)-8-azapurin-6-one; M&B 22,948 sildenafil viagra phophodiesterase cGMP PDE5 GRP35 inhibitors inhibits inhibition M&B 22948 55122-20-8 6.124180478821
10975 Zebularine 3690-10-6 ≥98% 2011-08-23 10.892338121546 zebularine DNMTs inhibitors DNA methyltransferases cancers cells analogs cytidines methylation carcinomaTK6 jurkat KG-1 HCT116 10.892338121546
13271 ZLJ-6 Exclusive 1051931-39-5 ≥98% ✓ 2009-06-17 36.043522099447 zlj-6 inhibitors cyclooxygenase COX-1 COX-2 5-lipoxygenase 5-LO inflammation pain ZLJ6 ZLJ 6 36.043522099447
10010367 ZM 336372 208260-29-1 >98% 2008-01-09 3.659251632345 zm-336372 Raf-1 c-raf inhibitors inhibition inhibits cancers anti-cancer MEK 1/2 MAPK signals transductions proliferations cells cycles ERK1 ERK2 ERK1/2 ATP adenosine triphosphate signaling carcinoid tumor 3.659251632345
13601 ZM 447439 331771-20-1 2010-08-03 7.050110497237 zm-447439 auroras A B C kinases mitosis cytokinesis centromere inhibitors inhibits inhibition cancers Benzamides 7.050110497237
9001083 α-Pyrrolidinopentiophenone (hydrochloride) Exclusive 5485-65-4 ≥98% ✓ 2011-10-11 90.620199780421 -pyrrolidinopentiophenone-hydrochloride α-PVP; 2-(1-pyrrolidinyl)-Valerophenone; O-2387 14530-33-7 designer drugs forensics pyrovalerone bath salts inhibits inhibitors inhibition transporters neurotransmitters dopamine norepinephrine uptake monoamine analogs alpha PVP APVP hydrochloride HCl psychoactive stimulant a-pvp apvp alpha-pyrrolidinopentiophenone 90.620199780421
10010947 β-cyano-L-Alanine 6232-19-5 ≥98% 2008-11-11 9.192958713069 -cyano-l-alanine BCA H2S gasotransmitter inhibitors inhibits inhibition CSE vasodilation inflammation sulfides 9.192958713069
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