Cayman Contract Services

• Custom Synthesis
  • Medicinal chemistry
  • Hit-to-Lead chemistry
  • Optimization of in vitro pharmacology SAR and ADMET
  • Route design, development, and scale-up synthesis for preclinical studies
  • Conjugation of small molecules to biomolecules
  • Fluorophore and biotinylated products
  • Heterocyclic chemistry
  • Cannabinoids
  • Toxic/Potent compounds
  • Stable isotopes including deuterium, ¹³C, ¹⁵N
  • Chiral synthesis and separations
  • Metabolites/Impurities
  • Reference standards
• Assay Services
  • Biochemists with experience in the areas of eicosanoids, steroids, oxidative stress, and inhibitor screening
  • Use Cayman’s extensive line of well-characterized biochemical kits
  • Enzyme immunoassay, colorimetric, and fluorometric assays available
• Analytical Services
  • Analytical chemists with extensive knowledge in the areas of eicosanoids, fatty acids, and pharmaceuticals
  • MS/MS, HPLC, NMR, and many other analytical techniques
  • HPLC purification services
• Screening Services
  • Comprehensive screening laboratory focused on epigenetics
  • Backed by our core strengths in protein production, assay development, chemical synthesis, and medicinal chemistry
  • Capacity to test compounds at a rate of up to 100,000 compounds per week
  • Ability to profile compounds against a broad epigenetic enzyme panel
  • Includes assays for methyltransferases, demethylases, acetyltransferases, deacetylases (HDACs and SIRTS), and histone code readers (ex. bromodomain proteins)