When it comes to understanding process and commercial manufacturing, no other manufacturer can match Cayman's knowledge of prostaglandin chemistry. Our chemists use this knowledge daily to synthesize commercially available eicosanoids as Active Pharmaceutical Ingredients (APIs).
Cayman is the industry leader in prostaglandin synthesis, with more than 30 years of experience. Our scientists, located in Ann Arbor, Michigan and Neratovice, Czech Republic, have filed numerous patents for the complex synthesis and commercial manufacture of more than 10 APIs, and additional compounds are currently under development.
Cayman's Center of Excellence in Ann Arbor focuses primarily on the synthesis, scale-up, and registration of new API manufacturing processes. Once registration batches have been completed, the GMP portion of the process and all supporting documentation is transferred to Cayman Pharma, our commercial manufacturing Center of Excellence in Neratovice. The facility at Cayman Pharma has more than 30 years of commercial prostaglandin and eicosanoid manufacturing experience, is ISO certified, and has an excellent track record with customers and regulatory authorities worldwide.
We currently manufacture the following APIs for commercial distribution. Contact our sales department for more information about pricing.
|30010||CGMP Epoprostenol (sodium salt)|
Alfaprostol is a bioactive analog of Prostaglandin F2ɑ. This injectable luteolytic agent is used for the scheduling of estrus in mares for purposes of planned breeding.
Tafluprost is a potent FP receptor agonist that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. GMP material should be available in late 2017.
Treprostinil (sodium) is a Prostacyclin (PGI2) analogue and potent vasodilator used for the treatment of pulmonary arterial hypertension. Development material made by the GMP route is currently available.
The majority of Cayman Chemical's commercial APIs are manufactured at our Manufacturing Center of Excellence in Neratovice, just outside of Prague in the Czech Republic. Our Cayman Pharma facility, which has ISO 9001, ISO 14001, and OHSAS 18001 certifications, has more than 30 years of experience in the commercial manufacturing of complex API molecules and specializes in the synthesis of prostaglandins. The site recently completed construction of nine, new, product-dedicated manufacturing suites, thus allowing full-scale production of products emerging from our development pipeline.
The Cayman advantage includes:
Our contract services group helps companies turn their new drug ideas into reality. Whether for phase I, phase II, phase III, or toxicology studies, we specialize in developing new synthetic routes while providing all necessary support to ensure regulatory compliance. The Cayman advantage offers the flexibility to support any size project, allowing you to create a customized service to meet your needs.
Our customized services include:
We have partnered with several clients in recent years and have an excellent track record of meeting our customers’ needs on or ahead of schedule. Contact us by calling toll free at (800) 364-9897 or by emailing firstname.lastname@example.org. You may also use the form below to provide project information, and a Cayman representative will contact you.
Cayman Pharma s.r.o.
ul. Práce 657
277 11 Neratovice
(+420) 315 664 381
(+420) 315 665 360
(+420) 315 665 384
You may also use the form below, and a Cayman representative will contact you.