Development of a chiral LC-MS/MS approach for measuring metabolites of the synthetic cannabinoids JWH-018 and AM2201

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This study further evaluated the utility of the new analytical procedure by assessing specific enantiomers in human specimens and by assaying in vitro reactions designed to determine the stereospecificity of neuronal cytochrome P450s (e.g. CYP2J2 and CYP2D6). Stereospecificity was observed in both clinical specimens and in vitro reactions using recombinant CYP2J2 and CYP2D6.

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