4-hydroperoxy 2-Nonenal
Item № 10004413
CAS № 7439-43-2
Purity ≥95%
500 µg $42.00 $0.00
1 mg $80.00 $0.00
5 mg $336.00 $0.00
10 mg $588.00 $0.00

Pricing updated 2016-05-24. Prices are subject to change without notice.

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  • 4-HpNE

4-hydroxy Nonenal (4-HNE; Item No. 32100) is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress.1,2 4-HNE exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.1,2,3 4-hydroperoxy 2-Nonenal is the immediate precursor of 4-HNE formed from the cleavage of ω-6 hydroperoxides.4 Analogous reactions are expected to occur with hydroperoxides from other ω-6 fatty acids, particularly arachidonic acid.

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Technical Information
Formal Name 4-hydroperoxy-2E-nonenal
CAS Number 7439-43-2
  • 4-HpNE
Molecular Formula C9H16O3
Formula Weight 172.2
Purity ≥95%
Formulation A solution in acetone
λmax 217, 271 nm
InChI Code 1S/C9H16O3/c1-2-3-4-6-9(12-11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8 541-543 (1990).

2. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11 81-128 (1991).

3. Sodum, R.S., and Chung, F. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res 48 320-323 (1988).

4. Schneider, C., Tallman, K.A., Porter, N.A., et al. Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. J Biol Chem 276(24) 20831-20838 (2001).

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