Item № 10006148
CAS № 1446-61-3
Purity ≥98%
5 mg $29.00 $0.00
10 mg $55.00 $0.00
25 mg $131.00 $0.00
50 mg $232.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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  • Dehydroabietylamine

Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means “play”. It has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.1 Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 value of 9.5 µM.2 Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A2 activity from a variety of sources.3

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Technical Information
Formal Name 1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine
CAS Number 1446-61-3
  • Dehydroabietylamine
Molecular Formula C20H31N
Formula Weight 285.5
Purity ≥98%
Formulation A solution in ethanol
SMILES CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3
InChI Code 1S/C20H31N/c1-14(2)15-6-8-17-16(12-15)7-9-18-19(3,13-21)10-5-11-20(17,18)4/h6,8,12,14,18H,5,7,9-11,13,21H2,1-4H3/t18-,19-,20+/m0/s1

WARNING - This product is not for human or veterinary use.

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Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Martin, B.R. Leelamine. (2006 Apr 27).

2. Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9 2223-2228 (1999).

3. Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A2 inhibitors. I. Eur J Med Chem 26 667-676 (1991).

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