Estradiol Benzoate
Item № 10006487
CAS № 50-50-0
Purity ≥98%
500 mg $25.00 $0.00
1 g $45.00 $0.00
5 g $138.00 $0.00

Pricing updated 2016-05-03. Prices are subject to change without notice.

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  • β-Estradiol Benzoate
  • 17β-Estradiol 3-Benzoate
  • 17β-Oestradiol Benzoate
  • E2 Benzoate

Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.1,2 Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. It is often used in combination with a progestin to induce estrus in domestic livestock.3 Estradiol benzoate binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in the range of 22-28 nM.4 This reflects a 6-10 fold reduction in binding affinity compared to estradiol.4

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Technical Information
Formal Name estra-1,3,5(10)-triene-3,17β-diol 3-benzoate
CAS Number 50-50-0
  • β-Estradiol Benzoate
  • 17β-Estradiol 3-Benzoate
  • 17β-Oestradiol Benzoate
  • E2 Benzoate
Molecular Formula C25H28O3
Formula Weight 376.5
Purity ≥98%
Formulation A crystalline solid
λmax 202, 230 nm
SMILES O=C(Oc1ccc2c(CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]32)c1)c1ccccc1
InChI Code 1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Miller, W.L., and Tyrrell, J.B. The adrenal cortex. 3rd edition 555-711 (1995).

2. Vance, D.E. Cholesterol and related derivatives. 2nd ed. 725-748 (1988).

3. Cavalieri, J., Hepworth, G., and Macmillan, K.L. Ovarian follicular development in Holstein cows following synchronisation of oestrus with oestradiol benxoate and an intravaginal progesterone releasing insert for 5-9 days and duration of the oestrous cycle and concentrations of progesterone following ovulation. Anim Reprod Sci 81 177-193 (2004).

4. Matthews, J., Celius, T., Halgren, R., et al. Differential estrogen receptor binding of estrogenic substances: A species comparison. J Steroid Biochem Mol Biol 74 223-234 (2000).

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