(R)-Bromoenol lactone
Item № 10006800
CAS № 478288-90-3
Purity ≥98%
500 µg $25.00 $0.00
1 mg $45.00 $0.00
5 mg $188.00 $0.00
10 mg $300.00 $0.00

Pricing updated 2016-04-30. Prices are subject to change without notice.

Bulk Inquiry Form


Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

  • (R)-BEL

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM.2 (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.

Download Product Insert Download Safety Data Sheet (SDS)

Related Products
View Related Product Categories
View Screening Libraries with (R)-Bromoenol lactone
Technical Information
Formal Name 6E-(bromoethylene)tetrahydro-3R-(1-naphthalenyl)-2H-pyran-2-one
CAS Number 478288-90-3
  • (R)-BEL
Molecular Formula C16H13BrO2
Formula Weight 317.2
Purity ≥98%
Formulation A solution in methyl acetate
λmax 222, 280 nm
SMILES Br/C=C(CC1)/OC([C@@]1([H])C2=CC=CC3=CC=CC=C32)=O
InChI Code 1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+/t15-/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
Product Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

QC Sheets
Certificates of Analysis
References & Background Reading
Product Description References

1. Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol 39 175-189 (1999).

2. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2).beta., and not iPLA2.gamma., as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. J Biol Chem 277(36) 32807-32814 (2002).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA