Item № 10007171
CAS № 55986-43-1
Purity ≥98%
5 mg $28.00 $0.00
10 mg $53.00 $0.00
50 mg $224.00 $0.00
100 mg $392.00 $0.00

Pricing updated 2016-05-01. Prices are subject to change without notice.

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  • Hexadecylamino-p-amino Benzoic Acid

The fibrate class of hypolipidemic drugs such as clofibrate and fenofibrate elicit their effects by binding to and activating peroxisome proliferator-activated receptor α (PPARα). Cetaben is a unique, peroxisome proliferator-activated receptor α (PPARα)-independent peroxisome proliferator with hypolipidemic activity, characterized by reduction in serum triglyceride and cholesterol concentrations in rats.1 In male wistar rats, cetaben increased the activity of all peroxisomal enzymes examined in liver and kidney, whereas clofibrate showed a varied regulatory pattern.2 In addition to its effects on peroxisomes, cetaben inhibits cholesterol synthesis in the human hepatoma HepG2 cells resulting in reversible changes in Golgi morphology.3,4 It also blocked triglyceride synthesis by 99% and reduced cholesterol ester synthesis by >70% at a concentration of 50 µM in these same cells.4

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Technical Information
Formal Name 4-(hexadecylamino)-benzoic acid
CAS Number 55986-43-1
  • Hexadecylamino-p-amino Benzoic Acid
Molecular Formula C23H39NO2
Formula Weight 361.6
Purity ≥98%
Formulation A crystalline solid
λmax 224, 304 nm
InChI Code 1S/C23H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-24-22-18-16-21(17-19-22)23(25)26/h16-19,24H,2-15,20H2,1H3,(H,25,26)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Chandoga, J., Hampl, L., Turecký, L., et al. Cetaben is an exceptional type of peroxisome proliferator. Int J Biochem 26(5) 679-696 (1994).

2. Chandoga, J., Rojeková, I., Hampl, L., et al. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Biochem Pharmacol 47(3) 515-519 (1994).

3. Kovacs, W., Walter, I., and Stangl, H. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma and HepG2 human hepatoblastoma cells. Histochem Cell Biol 115 509-519 (2001).

4. Kovacs, W., Schrader, M., Walter, I., et al. The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement. Histochem Cell Biol 122 95-109 (2004).

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