Prostaglandin F Ethanolamide Lipid Maps MS Standard
Item № 10007222
CAS № 353787-70-9
Purity ≥99%
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1 mg $68.00 $0.00
5 mg $306.00 $0.00
10 mg $544.00 $0.00

Pricing updated 2016-05-25. Prices are subject to change without notice.

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Description
Synonyms
  • Dinoprost Ethanolamide
  • PGF-EA

Prostaglandin F ethanolamide (PGF-EA) is produced by cyclooxygenase 2 (COX-2) metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues.1 AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs.2,3 PGF-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.4

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Technical Information
Formal Name N-(2-hydroxyethyl)-9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-amide
CAS Number 353787-70-9
Synonyms
  • Dinoprost Ethanolamide
  • PGF-EA
Molecular Formula C22H39NO5
Formula Weight 397.5
Purity ≥99%
Formulation A solution in ethanol
SMILES CCCCCC(O)/C=C/[C@H]1C(O)CC(O)C1C/C=C\CCCC(=O)NCCO

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

2. Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

3. Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277(47) 44877-44885 (2002).

4. Woodward, D.F., Tang-Liu, D.D., Madhu, C., et al. Prostaglandin F2.alpha. (PGF2.alpha.) 1-ethanolamide: A pharmacologically unique local hormone biosynthesized from anandamide. 27 (2000).

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