D-erythro-Sphingosine C-18
Item № 10007907
CAS № 123-78-4
Purity ≥98%
10 mg $35.00 $0.00
25 mg $79.00 $0.00
50 mg $140.00 $0.00
100 mg $210.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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  • (−)-Sphingosine

D-erythro-Sphingosine is formed primarily from the breakdown of ceramide.1 Sphingosine inhibits protein kinase C and phosphatic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.1 Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK 1, SPHK 2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.2,3,4

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Technical Information
Formal Name 2S-amino-4E-octadecene-1,3R-diol
CAS Number 123-78-4
  • (−)-Sphingosine
Molecular Formula C18H37NO2
Formula Weight 299.5
Purity ≥98%
Formulation A crystalline solid
InChI Code 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Hannun, Y.A., Luberto, C., and Argraves, K.M. Enzymes of sphingolipid metabolism: From modular to integrative signaling. Biochemistry 40(16) 4893-4903 (2001).

2. Takuwa, Y., Takuwa, N., and Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. J Biochem 131 767-771 (2002).

3. Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receptors: Signaling and biology. Annu Rev Biochem 73 321-354 (2004).

4. Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta 1582 72-80 (2002).

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