PtdIns-(4,5)-P2-biotin (sodium salt)
Item № 10008159
Purity ≥98%
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
10 µg $129.00 $0.00
25 µg $306.00 $0.00
50 µg $529.00 $0.00
100 µg $839.00 $0.00

Pricing updated 2016-04-29. Prices are subject to change without notice.

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Description
Synonyms
  • Phosphatidylinositol-4,5-diphosphate C-8-biotin

The PtdIns phosphates play an important role in the generation and transduction of intracellular signals.1 PtdIns-(4,5)-P2-biotin is an affinity probe which allows the PIP2 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(4,5)-P2 to serve as a general probe for any protein with a high affinity binding interaction with inositol-(4,5)-diphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

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Technical Information
Formal Name 1-((1-octanoyl-N’-biotinoyl-1,6-diaminohexane-2R-octanoyl)phosphatidyl)inositol-4,5-bisphosphate, trisodium salt
Synonyms
  • Phosphatidylinositol-4,5-diphosphate C-8-biotin
Molecular Formula C35H61N3O21P3S · 3Na
Formula Weight 1053.8
Purity ≥98%
Formulation A lyophilized powder
SMILES O[C@H]1[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](O)[C@H](O)[C@@H]1OP([O-])(OC[C@H](COC(CCCCCCCNC(CCCC[C@H]2SC[C@@](N3[H])([H])[C@]2([H])N([H])C3=O)=O)=O)OC(CCCCCCC)=O)=O.[Na+].[Na+].[Na+]
InChI Code 1S/C35H64N3O21P3S.3Na/c1-2-3-4-6-10-17-27(41)56-22(20-55-62(52,53)59-32-29(42)30(43)33(57-60(46,47)48)34(31(32)44)58-61(49,50)51)19-54-26(40)16-9-7-5-8-13-18-36-25(39)15-12-11-14-24-28-23(21-63-24)37-35(45)38-28;;;/h22-24,28-34,42-44H,2-21H2,1H
InChI Key USLRCVJGAGJDIV-WFWFDGKXSA-K

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
Product Downloads & Resources
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Additional Information

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Inserts
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GCMS Data
References & Background Reading
Product Description References

1. Rückle, T., Schwarz, M.K., and Rommel, C. PI3K.gamma. inhibition: Towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5 903-918 (2006).

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