8-iso-17-phenyl trinor Prostaglandin F
Item № 10008435
Purity >98%
1 mg $138.00 $0.00
5 mg $621.00 $0.00
10 mg $1,104.00 $0.00

Pricing updated 2016-04-29. Prices are subject to change without notice.

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8-iso-17-phenyl trinor Prostaglandin F (8-iso-17-phenyl trinor PGF) is the C-8 epimer of bimatoprost (free acid), a metabolically stable analog of PGF. Bimatoprost (free acid) binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF.1 At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF binding with a Ki of 1.1 nM.2 There are no published studies of the pharmacological properties of 8-iso-17-phenyl trinor PGF.

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Technical Information
Formal Name 9α,11α,15S-trihydroxy-17-phenyl-18,19,20-trinor-(8β)-prosta-5Z,13E-dien-1-oic acid
Molecular Formula C23H32O5
Formula Weight 388.5
Purity >98%
Formulation A solution in methyl acetate
SMILES O[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1
InChI Code 1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19-,20+,21-,22+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2.alpha. receptor. Biochem Pharmacol 38 2375-2381 (1989).

2. Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2.alpha. receptors and the expression of the rat prostaglandin F2.alpha. receptor. FEBS Lett 355 317-325 (1994).

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