D-myo-Inositol-1,4-diphosphate (sodium salt)
Item № 10008438
Purity ≥98%
100 µg $49.00 $0.00
500 µg $221.00 $0.00
1 mg $392.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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  • Ins(1,4)-P2 (sodium salt)
  • 1,4-IP2 (sodium salt)

D-myo-Inositol-1,4-phosphate (Ins(1,4)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.1,2 The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate.3,4 Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4,5 Ins(1,4)P2 can be dephosphorylated to Ins(4)P by inositol polyphosphate 1-phosphatase and further dephosphorylated to inositol by inositol monophosphatase.2

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Technical Information
Formal Name D-myo-inositol-1,4-bis(dihydrogen phosphate), disodium salt
  • Ins(1,4)-P2 (sodium salt)
  • 1,4-IP2 (sodium salt)
Molecular Formula C6H12O12P2 · 2Na
Formula Weight 384.1
Purity ≥98%
Formulation A lyophilized powder
SMILES O[C@H]1[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](O)[C@@H](OP([O-])(O)=O)[C@@H]1O.[Na+].[Na+]
InChI Code 1S/C6H14O12P2.2Na/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13;;/h1-10H,(H2,11,12,13)(H2,14,15,16);;/q;2*+1/p-2/t1-,2-,3-,4+,5?,6?;;/m1../s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2. Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3. Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

4. Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

5. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

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